Search results for "AOS"
showing 10 items of 330 documents
Pathogenesis and molecular mechanisms of anderson–fabry disease and possible new molecular addressed therapeutic strategies
2021
Anderson–Fabry disease (AFD) is a rare disease with an incidenceof approximately 1:117,000 male births. Lysosomal accumulation of globotriaosylceramide (Gb3) is the element characterizing Fabry disease due to a hereditary deficiency α-galactosidase A (GLA) enzyme. The accumulation of Gb3 causes lysosomal dysfunction that compromises cell signaling pathways. Deposition of sphingolipids occurs in the autonomic nervous system, dorsal root ganglia, kidney epithelial cells, vascular system cells, and myocardial cells, resulting in organ failure. This manuscript will review the molecular pathogenetic pathways involved in Anderson–Fabry disease and in its organ damage. Some studies reported that i…
Early Warning Systems for Food Security in West Africa: Evolution, Achievements and Challenges
2010
In West Africa, early warning systems (EWSs) for food security have been widely recognized to have contributed, in the last 20 years, to an improved ability to deal with famine emergencies. Nevertheless, despite the advancements in understanding of the environmental and socio-economic dynamics and despite the improved technologies, tackling food security remains a difficult task for decision makers as demonstrated by local food crises in many countries of the region. African Monsoon Multidisciplinary Analysis, while improving the understanding of the monsoon system, allowed us to better orient research challenges to provide EWS with improved products, effectively meeting the needs of end-us…
Rice cooking and sensory quality
2019
International audience; This chapter provides a state-of-the-art review of the diversity and dynamics of consumer demand with respect to the eating quality of rice worldwide. Quality includes both tangible measurable factors (rice characteristics) and the context of consumption. The main sensory attributes evaluated around the world are described, and their relationship with the diversity of consumer demand is discussed. Instrumental methods for predicting quality measured on either raw or cooked grains are reviewed. The changes that occur in the rice grain during cooking are described along with a modeling approach able to predict the changes and their spatial distribution in the rice grai…
Effects of garlic powders with varying alliin contents on hepatic drug metabolizing enzymes in rats
2003
International audience; The anticarcinogenic effect of garlic has been demonstrated in both epidemiologic and experimental studies. In this study, possible mechanisms involved in the anticarcinogenic effect of garlic consumption were assessed by determining its capacity to alter drug metabolizing enzymes, in relation with its alliin content. Rats were fed a diet for 2 weeks containing 5% garlic powders produced from bulbs grown on soils with different levels of sulfate fertilization and therefore containing differing amounts of alliin. Activities of several hepatic enzymes, which are important in carcinogen metabolism such cytochromes P450 (CYP) and phase II enzymes, were determined. Garlic…
Introduction
2014
Nowadays, software engineers face a wide range of particular application domains such as electronic commerce, enterprise resource planning, mobile computing, self-organisation, pervasive and adaptive computing, etc. The resulting heterogeneity and required functionalities call for complex systems and open architectures that may evolve dynamically over time so as to accommodate new components and meet new requirements. This is probably one of the main reasons why the agent metaphor and agent-based computing are gaining momentum in these areas.
Comment améliorer la prévision des ventes pour le marketing ? Les apports de la théorie du chaos
2013
National audience; La littérature en marketing constate un décalage entre les avancées réalisées par les chercheurs qui développent de nouvelles méthodes de prévision des ventes, et l'usage massif de méthodes traditionnelles reposant sur l'hypothèse de linéarité des processus analysés. Cette recherche expose la contribution poten¬tielle de la théorie du chaos à l'amélioration de la prévision des ventes. Une illustration de ces apports est proposée avec une application à la prévision des ventes de consoles de jeux vidéo au Japon. Les résultats mettent en évidence la capacité de la méthode proposée à détecter la présence de chaos dans la série et montrent la possibilité de préciser l'horizon …
Biosilica-loaded poly(ϵ-caprolactone) nanofibers mats provide a morphogenetically active surface scaffold for the growth and mineralization of the os…
2014
Bioprinting/3D cell printing procedures for the preparation of scaffolds/implants have the potential to revolutionize regenerative medicine. Besides biocompatibility and biodegradability, the hardness of the scaffold material is of critical importance to allow sufficient mechanical protection and, to the same extent, allow migration, cell–cell, and cell–substrate contact formation of the matrix-embedded cells. In the present study, we present a strategy to encase a bioprinted, cell-containing, and soft scaffold with an electrospun mat. The electrospun poly(e-caprolactone) (PCL) nanofibers mats, containing tetraethyl orthosilicate (TEOS), were subsequently incubated with silicatein. Silicate…
Development of a morphogenetically active scaffold for three-dimensional growth of bone cells: biosilica-alginate hydrogel for SaOS-2 cell cultivation
2013
Polymeric silica is formed from ortho-silicate during a sol–gel formation process, while biosilica is the product of an enzymatically driven bio-polycondensation reaction. Both polymers have recently been described as a template that induces an increased expression of the genes encoding bone morphogenetic protein 2 (BMP-2) and osteoprotegerin in osteoblast-related SaOS-2 cells; simultaneously or subsequently the cells respond with enhanced hydroxyapatite formation. In order to assess whether the biocompatible polymeric silica/biosilica can serve as a morphogenetically active matrix suitable for three-dimensional (3D) cell growth, or even for 3D cell bioprinting, SaOS-2 cells were embedded i…
Living and Not-living Matter: Complexity and Self-Organisation in Kauffman
2016
Which is the relation between the living and not-living matter? In this paper I’ll try to give this question an answer and to explore the underlying framework. I think that the theoretical biologist Stuart Kauffman develops an outstanding and interesting approach, which is formulated within the research field of the non-equilibrium chaotic systems dynamics, the theory of complexity and self-organization and the recent debate on the evolution. Therefore, my aim is to show the way in which Kauffman employs the concept of self-organization to build a not reductionist model that may account for the issues concerning the living and not-living matter by integrating physics with biology. In genera…
CONTRIBUTO ALLE CONOSCENZE LICHENOLOGICHE DELLA VALLE D’AOSTA: FLORULA DELLA CONCA DI FLASSIN (VALLE DEL GRAN SAN BERNARDO)
2008
Complessivamente sono stati censiti 75 taxa che rappresentano il primo ritrovamento per il sito indagato. Nel corso dell’escursione sono state raccolte 6 specie (Caloplaca inconnexa v. inconnexa, Lecanora rupicola ssp. subplanata, Lecanora subcarpinea, Protoparmeliopsis muralis v. dubyi, Rhizocarpon macrosporum, Tetramelas triphragmioides) di nuova segnalazione per la Valle d’Aosta. Solo quattro entità tra quelle censite risultano già note per la Valle del Gran San Bernardo: Cladonia gracilis, Peltigera didactyla, Rhizocarpon geographicum e R. lecanorinum vennero segnalate in prossimità della vetta del Mont Mort (Vaccari, 1914). Attualmente gli esemplari sono conservati presso l’Erbario del…