Search results for "APACHE"
showing 10 items of 27 documents
Predicting patient outcome from acute renal failure comparing three general severity of illness scoring systems
2000
Predicting patient outcome from acute renal failure comparing three general severity of illness scoring systems.BackgroundA major problem of studies on acute renal failure (ARF) arises from a lack of prognostic tools able to express the medical complexity of the syndrome adequately and to predict patient outcome accurately. Our study was thus aimed at evaluating the predictive ability of three general prognostic models [version II of the Acute Physiology and Chronic Health Evaluation (APACHE II), version II of the Simplified Acute Physiology Score (SAPS II), and version II of the Mortality Probability Model at 24 hours (MPM24 II)] in a prospective, single-center cohort of patients with ARF …
Association between increased arterial stiffness and clinical outcomes in patients with early sepsis: a prospective observational cohort study.
2019
Background Conduit arteries, especially the aorta, play a major role in ensuring efficient cardiac function and optimal microvascular flow due to their viscoelastic properties. Studies in animals and on isolated arteries show that acute systemic inflammation can cause aortic stiffening which affects hemodynamic efficiency. Carotid-femoral pulse wave velocity, a measure of aortic stiffness, may be useful as a bedside investigational method in patients with early sepsis admitted to intensive care, as circulatory changes can lead to multiple organ failure and increased mortality. This study aims to investigate arterial stiffness in early sepsis and its association with clinical outcomes. Metho…
Predicción de la mortalidad de pacientes con enfermedad hematológica que requieren ingreso en la Unidad de Cuidados Intensivos
2013
HIPÓTESIS: Existen variables clínicas e índices pronósticos que permiten establecer la probabilidad de muerte en pacientes con neoplasias hematológicas cuando se propone su ingreso en la Unidad de Cuidados Intensivos (UCI). La valoración evolutiva de estos índices pronósticos puede aumentar su potencia predictora y tener utilidad en la toma de decisiones tras el ingreso en UCI.OBJETIVOS:Principales 1)Identificar los factores de riesgo que puedan predecir la mortalidad de los enfermos hematológicos que requieren ingreso en UCI.2)Validar los índices pronósticos APACHE II, ICMM, SOFA y valoración evolutiva del índice SOFA en este grupo de pacientes.Secundarios: Analizar la mortalidad de los en…
[Prognostic value of interleukin 6 for death of patients with sepsis].
2016
Abstract Background and objective To see the influence of interlukin-6 (IL-6) as an inflammatory mediator in patients with systemic inflammatory response syndrome (SIRS) and sepsis, assessing whether their serum levels during their stay in intensive care unit (ICU) serve as an early mortality prognostic marker. Material and methods A prospective observational cohort study with 203 ICU patients from a third level hospital. A descriptive analysis was made, X 2 test used to compare qualitative variables, T -Student test to compare quantitative ones. We made a logistic regression multivariant analysis on admission, third and seventh day of stay with dependent variable mortality and independent …
Clinical significance of increased intraabdominal pressure in severe acute pancreatitis.
2002
The aim of the study was to assess whether increased intra-abdominal pressure affects the clinical course and reflects on the effectiveness of the conservative treatment in patients with severe acute pancreatitis. Data on 37 consecutive patients with severe acute pancreatitis that were collected prospectively included APACHE II score, daily measurement of the intra-abdominal pressure, and clinical routine. Group A consisted of 26 patients with intra-abdominal pressure < 25 cm/H 2 O during their treatment period, and group B consisted of 11 patients with intraabdominal pressure ≥ 25 cm/H 2 O. SIRS, MODS, complication rate and mortality were analysed. The age, APACHE II scores and hospital st…
Influence of inadequate antimicrobial therapy on prognosis in elderly patients with severe urinary tract infections.
2013
Abstract Background Inadequate empirical antimicrobial therapy (IEAT) in intensive care unit (ICU) is associated with adverse outcomes. However, the influence of IEAT on prognosis for elderly patients with urinary tract infection (UTI) in non-ICU settings is unknown. Methods A retrospective cross-sectional study of elderly patients admitted to a non-ICU ward in a university hospital with a primary diagnosis of UTI over a 3-year period was done. Data relating to age, sex, background comorbidities, severity of infection, bacteremia, microorganisms isolated in urine, treatment given, length of stay and prognosis were obtained using chart review. Cases were segregated according to the adequacy …
DALI: Defining Antibiotic Levels in Intensive Care Unit Patients: Are Current -Lactam Antibiotic Doses Sufficient for Critically Ill Patients?
2014
Background. Morbidity and mortality for critically ill patients with infections remains a global healthcare problem. We aimed to determine whether α-lactam antibiotic dosing in critically ill patients achieves concentrations associated with maximal activity and whether antibiotic concentrations affect patient outcome.Methods. This was a prospective, multinational pharmacokinetic point-prevalence study including 8 α-lactam antibiotics. Two blood samples were taken from each patient during a single dosing interval. The primary pharmacokinetic/pharmacodynamic targets were free antibiotic concentrations above the minimum inhibitory concentration (MIC) of the pathogen at both 50% (50% f TMIC) an…
Stratification for Identification of Prognostic Categories In the Acute RESpiratory Distress Syndrome (SPIRES) Score.
2021
OBJECTIVES: To develop a scoring model for stratifying patients with acute respiratory distress syndrome into risk categories (Stratification for identification of Prognostic categories In the acute RESpiratory distress syndrome score) for early prediction of death in the ICU, independent of the underlying disease and cause of death. DESIGN: A development and validation study using clinical data from four prospective, multicenter, observational cohorts. SETTING: A network of multidisciplinary ICUs. PATIENTS: One-thousand three-hundred one patients with moderate-to-severe acute respiratory distress syndrome managed with lung-protective ventilation. INTERVENTIONS: None. MEASUREMENTS AND MAIN …
Grenzen der Indikation zur Intensivtherapie bei chirurgischen Patienten — Prospektive Untersuchung zur Bedeutung von Scores (APACHE II, HIS, TISS) un…
1993
The aim of the study was to describe the objective factors (clinical values, scores, basic and concomitant illnesses) that could possibly justify the omittance of intensive therapy. In a prospective study in 169 postoperative intensive therapy patients, it was shown that scores (APACHE II, HIS, TISS) serum-lactate and serum creatinine were significant prognostic parameters for lethal outcome, while these parameters had no effect on the prognosis after patients were discharged. Primarily, the presence of a malignant disease and/or the age of the patient were decisive. By considering these factors for lethal outcome and long-term prognosis, it is possible to identify patients who do not benef…
Utility of presepsin (sCD14-ST) as a diagnostic and prognostic marker of sepsis in the emergency department
2015
Presepsin (PSEP) is released during infectious diseases and can be detected in the blood. PSEP has shown promising results as sepsis marker. We examined the diagnostic and prognostic validity of PSEP in patients suspicious of sepsis on admission in the emergency department (ED). Methods One hundred twenty three patients with signs of SIRS and/or sepsis and 123 healthy individuals were enrolled. PSEP was determined on admission, after 8, 24 and 72 h. Results Mean PSEP concentrations of the control group and the patient group were 130 and 1945 pg/ml. PSEP differed between SIRS, sepsis, severe sepsis and septic shock and showed strong association with 30-day mortality ranging from 10.3% in the…