Search results for "APAR"
showing 10 items of 848 documents
Halo-independent methods for inelastic dark matter scattering
2013
We present halo-independent methods to analyze the results of dark matter direct detection experiments assuming inelastic scattering. We focus on the annual modulation signal reported by DAMA/LIBRA and present three different halo-independent tests. First, we compare it to the upper limit on the unmodulated rate from XENON100 using (a) the trivial requirement that the amplitude of the annual modulation has to be smaller than the bound on the unmodulated rate, and (b) a bound on the annual modulation amplitude based on an expansion in the Earth's velocity. The third test uses the special predictions of the signal shape for inelastic scattering and allows for an internal consistency check of …
Efecto de la profundidad del bloqueo neuromuscular sobre el espacio abdominal y las condiciones quirúrgicas durante la cirugía laparoscópica abdomina…
2017
Introducción: La anestesia aparece como un factor clave en el desarrollo del proceso asistencial de la cirugía laparoscópica, por su capacidad de actuar tanto sobre los factores barrera que condicionan el período postoperatorio y el alta hospitalaria precoz, como por la posibilidad de influir en la optimización de las condiciones quirúrgicas. Sin embargo, mientras que existen recomendaciones con una evidencia científica de grado A en cuanto a intervenciones sobre el control de las náuseas/vómitos postoperatorios(NVPO), estrategias para el control del dolor postquirúrgico o para la mejora en la calidad de la recuperación postoperatoria, la evidencia científica presente hasta el momento en re…
Ode laica per Chibok e Leah
2019
The volume contains two short poems by Nigerian Nobel Laureate Wole Soyinka ("No, He Said!", dedicated to Nelson Mandela, from the Author's 1988 classic collection "Mandela's Earth and Other Poems", and the recent "Mandela Comes to Leah", written purposely for this volume), along with the most recent long poem in five parts "A Humanist Ode to Chibok, Leah", published in English for the first time in 2019. The poem, and indeed the entire volume, denounces all forms of fundamentalism and fanaticism as opposed to secular humanism. Soyinka pays tribute to the girls abducted in Chibok and 15 year-old Leah Sharibu, one of the 108 girls abducted from Dapchi in 2018, comparing her firm refusal to r…
La colangiografia intraoperatoria in corso di colecistectomia videolaparoscopica: quale ruolo?
2007
The routine use of intraoperative cholangiography during laparoscopic cholecystectomy remains controversial. Mirizzi was the first to recommend the use of intraoperative cholangiography in 1931 based on the high incidence of unsuspected common bile duct stones. The use of intraoperative cholangiography before common bile duct exploration reduced the incidence of unnecessary common bile duct explorations from 66% to less than 5%. With the introduction of laparoscopic cholecystectomy, an increase of incidence of bile duct injury two to four times that seen in open cholecystectomy was witnessed. The vast majority of the injuries were a direct result of the surgeon misidentifying the anatomy. T…
Difficult laparoscopic cholecystectomy and preoperative predictive factors
2021
AbstractLaparoscopic cholecystectomy (LC) is the standard technique for treatment of gallbladder disease. In case of acute cholecystitis we can identify preoperative factors associated with an increased risk of conversion and intraoperative complications. The aim of our study was to detect preoperative laboratory and radiological findings predictive of difficult LC with potential advantages for both the surgeons and patients in terms of options for management. We designed a retrospective case–control study to compare preoperative predictive factors of difficult LC in patients treated in emergency setting between January 2015 and December 2019. We included in the difficult LC group the surge…
Phase III randomised clinical trial comparing primary surgery versus neoadjuvant chemotherapy in advanced epithelial ovarian cancer with high tumour …
2016
Abstract Objective To establishing whether neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS) is superior primary debulking surgery (PDS) in terms of clinical outcome as well as peri-operative morbidity in advanced epithelial ovarian cancer (AEOC) endowed with high tumour load (HTL). Material and methods This is a single-Institution, superiority, randomised phase III trial enrolling supposed AEOC women. Patients considered pre-operatively eligible were triaged to staging laparoscopy to assess the predictive index (PI) of tumour load. All AEOC women with PI ≥ 8 or ≤ 12 (considered as HTL) were included. They were randomly assigned (1:1 ratio) to undergo either PDS f…
Sexual, bladder and bowel function following different minimally invasive techniques of radical hysterectomy in patients with early-stage cervical ca…
2021
Abstract Purpose Despite the establishment of radical surgery for therapy of cervical cancer, data on quality of life and patient-reported outcomes are scarce. The aim of this retrospective cohort study was to evaluate bladder, bowel and sexual function in women who underwent minimally invasive surgery for early-stage cervical cancer. Methods From 2007–2013, 261 women underwent laparoscopically assisted radical vaginal hysterectomy (LARVH = 45), vaginally assisted laparoscopic or robotic radical hysterectomy (VALRRH = 61) or laparoscopic total mesometrial resection (TMMR = 25) and 131 of them completed the validated German version of the Australian Pelvic Floor Questionnaire (PFQ). Results …
Sentinel lymph node mapping with indocyanine green in cervical cancer patients undergoing open radical hysterectomy: a single-institution series
2020
Abstract Purpose To assess the rate of bilateral sentinel lymph node (SLN) detection with indocyanine green (ICG), to evaluate the sensitivity and the negative predictive value of cervical cancer patients undergoing open radical hysterectomy; to compare open versus minimally invasive SLN biopsy performance and to assess factors related to no/unilateral SLN mapping. Methods We retrospectively reviewed consecutive patients with FIGO 2018 stage IA1 with lymph-vascular space involvement to IIB and IIIC1p cervical carcinoma who underwent SLN mapping with ICG followed by systematic pelvic lymphadenectomy between 05/2017 and 06/2020. Patients were divided according to surgical approach for statist…
A Multicentric Randomized Trial to Evaluate the ROle of Uterine MANipulator on Laparoscopic/Robotic HYsterectomy for the Treatment of Early-Stage End…
2021
ObjectiveThis prospective randomized trial aimed to assess the impact of the uterine manipulator in terms of lymph vascular space invasion (LVSI) in patients undergoing minimally invasive staging for early-stage endometrial cancer.MethodsIn this multicentric randomized trial, enrolled patients were randomly allocated in two groups according to the no use (arm A) or the use (arm B) of the uterine manipulator. Inclusion criteria were G1-G2 early-stage endometrial cancer at preoperative evaluation. The variables collected included baseline demographic characteristics, perioperative data, final pathology report, adjuvant treatment, and follow-up.ResultsIn the study, 154 patients (76 in arm A an…
Rad51 and BRCA2 - New Molecular Targets for Sensitizing Glioma Cells to Alkylating Anticancer Drugs
2011
First line chemotherapeutics for brain tumors (malignant gliomas) are alkylating agents such as temozolomide and nimustine. Despite growing knowledge of how these agents work, patients suffering from this malignancy still face a dismal prognosis. Alkylating agents target DNA, forming the killing lesion O(6)-alkylguanine, which is converted into DNA double-strand breaks (DSBs) that trigger apoptosis. Here we assessed whether inhibiting repair of DSBs by homologous recombination (HR) or non-homologous end joining (NHEJ) is a reasonable strategy for sensitizing glioma cells to alkylating agents. For down-regulation of HR in glioma cells, we used an interference RNA (iRNA) approach targeting Ra…