Search results for "API"
showing 10 items of 8586 documents
Induction of body weight loss through RNAi-knockdown of APOBEC1 gene expression in transgenic rabbits
2014
In the search of new strategies to fight against obesity, we targeted a gene pathway involved in energy uptake. We have thus investigated the APOB mRNA editing protein (APOBEC1) gene pathway that is involved in fat absorption in the intestine. The APOB gene encodes two proteins, APOB100 and APOB48, via the editing of a single nucleotide in the APOB mRNA by the APOBEC1 enzyme. The APOB48 protein is mandatory for the synthesis of chylomicrons by intestinal cells to transport dietary lipids and cholesterol. We produced transgenic rabbits expressing permanently and ubiquitously a small hairpin RNA targeting the rabbit APOBEC1 mRNA. These rabbits exhibited a moderately but significantly reduced …
Study of very forward energy and its correlation with particle production at midrapidity in pp and p-Pb collisions at the LHC
2022
Journal of high energy physics 08(8), 86 (2022). doi:10.1007/JHEP08(2022)086
Tarkkaavaisuushäiriöinen oppilas musiikin tunneilla : esimerkkinä Jyväskylän seudun musiikinopetus perusopetuksen vuosiluokilla 7.-9.
2005
Fight evolution with evolution: plasmid‐dependent phages with a wide host range prevent the spread of antibiotic resistance
2013
The emergence of pathogenic bacteria resistant to multiple antibiotics is a serious worldwide public health concern. Whenever antibiotics are applied, the genes encoding for antibiotic resistance are selected for within bacterial populations. This has led to the prevalence of conjugative plasmids that carry resistance genes and can transfer themselves between diverse bacterial groups. In this study, we investigated whether it is feasible to attempt to prevent the spread of antibiotic resistances with a lytic bacteriophage, which can replicate in a wide range of gram‐negative bacteria harbouring conjugative drug resistance–conferring plasmids. The counter‐selection against the plasmid was sh…
Antibacterial Efficiency of Surface-Immobilized Flavobacterium-Infecting Bacteriophage
2019
Control of bacterial diseases by bacteriophages (phages) is gaining more interest due to increasing antibiotic resistance. This has led to technologies to attach phages on surfaces to form a biomaterial that can functionally display phages that interact with bacteria, to carry out successful infection cycles. Such a material could be applied in many environments, where the target pathogens are expected. Although this approach has been applied successfully in a few studies already, the basis of the antibacterial effect by the immobilized phages is unclear, and the interpretation of the results depends on the study. Here, we studied the phage attachment density, their detachment rate and infe…
Exploring phage-bacterium interactions : new ways to combat a fish pathogen
2014
Dataset for Mucin induces CRISPR-Cas defense in an opportunistic pathogen
2022
This dataset contains raw data points of (1) phage-bacterium co-evolution experiment (flavobacterium columnare colony counts, phage counts, bacterial growth characteristics and number of CRISPR-Cas spacers) and (2) from competition experiment between Flavobacterium columnare and Aeromonas sp. For detailed method description, see the attached Documentation file.
Study on the mechanism of action of antitumor photochemotherapic agents by means of docking and QSPR analysis
2008
Problem-Based Learning in Professional Studies from the Physiotherapy Students’ Perspective
2018
The aim of the study was to investigate how physiotherapy students using a problem-based learning approach develop into experts during higher education, and answers the question: How do physiotherapy students at bachelor’s level understand the problem-based learning approach while learning to become professionals? PBL is examined using interpretative phenomenological analysis (IPA) of longitudinal data written by 15 voluntary students from two different higher education institutions and collected during 3.5 years. The main results on the new way of learning strengthen earlier conceptions of the importance of reflection in the learning process. The PBL method activates a reflection process b…
Pilvipalvelun ja teollisuuden ohjausjärjestelmän välisen rajapinnan toteutus
2017
Teollisuuden ohjaus- ja valvontajärjestelmät ovat toimineet pitkään tehdasprosessien sisäisinä itsenäisinä ja suljettuina järjestelminä. Nykypäivän trendi on, että näistä automaatiojärjestelmistä (Process Automation System) ja niiden ohjaamista prosesseista haluttaisiin kerätä tietoa keskitetysti verkon yli. Aikaisemmin tämä tiedonkeruu on tapahtunut järjestelmän sisällä samassa toimitilassa. Tiedonkeruun toteutukseen tarvittaisiin rajapinta (Interface), joka toimisi pilvipalvelun (Cloud service) ja teollisuudenjärjestelmän välillä. Rajapinta mahdollistaisi monenlaisten tietojen keruun teollisuudenjärjestelmistä keskitetysti pilvipalveluun. Tulevaisuudessa ja jopa nykypäivänä tiedon keräämi…