Search results for "APRI"
showing 10 items of 274 documents
Relaxation of the isolated human internal anal sphincter by sildenafil.
2007
Abstract Background Hypertonicity of the internal anal sphincter (IAS) appears to be involved in the pathogenesis of anal fissure. The relaxant effects of sildenafil, a selective phosphodiesterase 5 (PDE5) inhibitor, on isolated human IAS were investigated. Methods The efficacy (maximal effect, Emax) and potency (−log IC50, where IC50 is half-maximal inhibitory concentration) of the PDE5 inhibitors, sildenafil and zaprinast, and of nitric oxide donors, sodium nitroprusside and glyceryl trinitrate, as relaxants of histamine (0·1 mmol/l)-induced tone were examined in IAS strips under isometric contraction. The presence of PDE5 isoenzymes and changes in intracellular calcium and cyclic nucleot…
Dual emission of a bis(pyrene)-functionalized, perbenzylated beta-cyclodextrin
2008
A bis(pyrene)-functionalized β-cyclodextrin (1) has been prepared in two steps from perbenzylated β-cyclodextrin. This compound shows dual emission properties, which arise from the pyrenyl chromophores. Upon excitation of 1 at 355 nm, monomer blue fluorescence (386, 407 and 428 nm) is observed in DMSO solution, whereas excimer green fluorescence (477 nm) is seen upon addition of ≥20 vol% water in DMSO. This suggests that modified β-cyclodextrin 1 changes its shape in response to the environment. The sensing properties of 1 towards carboxylic acids and alcohols were investigated in H2O–DMSO (80 : 20 v/v). Monomer fluorescence is restored selectively by medium length normal carboxylic acids, …
Angiotensin Receptor Neprilysin Inhibition Compared With Enalapril on the Risk of Clinical Progression in Surviving Patients With Heart Failure
2015
Background— Clinical trials in heart failure have focused on the improvement in symptoms or decreases in the risk of death and other cardiovascular events. Little is known about the effect of drugs on the risk of clinical deterioration in surviving patients. Methods and Results— We compared the angiotensin-neprilysin inhibitor LCZ696 (400 mg daily) with the angiotensin-converting enzyme inhibitor enalapril (20 mg daily) in 8399 patients with heart failure and reduced ejection fraction in a double-blind trial. The analyses focused on prespecified measures of nonfatal clinical deterioration. In comparison with the enalapril group, fewer LCZ696-treated patients required intensification of med…
Polyphenols pattern and correlation with antioxidant activities of berries extracts from four different populations of SicilianSambucus nigraL.
2014
Sambucus nigra L. (Caprifoliaceae) is wide spread in temperate and sub-tropical zones. The consumption of its berries has been associated with health benefits especially for its high content of natural antioxidants such as polyphenols, in particular anthocyanins. In this work we investigated the polyphenolic composition and the in vitro antioxidant activities (ABTS, DPPH, BCB and FRAP-ferrozine (FRAP-FZ) assays) of S. nigra berries, collected in four different Sicilian areas (Italy). Elderberries are considered one of the fruits with highest anthocyanins content, the amount of phenolic compounds, other than anthocyanins, is approximately 1.5 times greater than the latter. The LC–MS analyses…
Apgrozāmie līdzekļi un to uzskaite un izmantošanas efektivitāte SIA "Rilita"
2016
Diplomdarba mērķis ir izpētīt un novērtēt apgrozāmo līdzekļu uzskaiti un izmantošanas efektivitāti SIA „RILITA” un izstrādāt priekšlikumus konstatēto problēmu risināšanai. Darbā tiek pētīti apgrozāmie līdzekļi, to uzskaite un izmantošanas efektivitāte literatūras avotos un LR regulējumos no teorētiskā aspekta, novērtēti un analizēti SIA „RILITA” apgrozāmie līdzekļi, to uzskaite un izmantošanas efektivitāte. Darba izstrādes laikā autore konstatēja SIA „RILITA” vairākas problēmas – zemi finanšu rādītāji un apgrozāmo līdzekļu izmantošanas efektivitātes rādītāji, gada pārskata sastādīšanas noteikumu neatbilstība un citas, kā ari izstrādāja priekšlikumus to uzlabošanai.
First stages of microsporere programming to embryogenesis through anther culture in Prunus armeniaca L.
2011
6 páginas, 3 figuras, 2 tablas -- PAGS nros. 152-157
Induction of pollen embryogenesis in seven cultivars of Prunus armeniaca l.
2010
6 páginas -- PAGS nros. 273-278
Sequential Mining Classification
2017
Sequential pattern mining is a data mining technique that aims to extract and analyze frequent subsequences from sequences of events or items with time constraint. Sequence data mining was introduced in 1995 with the well-known Apriori algorithm. The algorithm studied the transactions through time, in order to extract frequent patterns from the sequences of products related to a customer. Later, this technique became useful in many applications: DNA researches, medical diagnosis and prevention, telecommunications, etc. GSP, SPAM, SPADE, PrefixSPan and other advanced algorithms followed. View the evolution of data mining techniques based on sequential data, this paper discusses the multiple …
Medical Data Mining for Heart Diseases and the Future of Sequential Mining in Medical Field
2018
Data Mining in general is the act of extracting interesting patterns and discovering non-trivial knowledge from a large amount of data. Medical data mining can be used to understand the events happened in the past, i.e. studying a patients vital signs to understand his complications and discover why he has died, or to predict the future by analyzing the events that had happened. In this chapter we are presenting an overview on studies that use data mining to predict heart failure and heart diseases classes. We will also focus on one of the trendiest data-mining field, namely the Sequential Mining, which is a very promising paradigm. Due to its important results in many fields, this chapter …
Overview on Sequential Mining Algorithms and Their Extensions
2018
The main purpose of data mining is to extract hidden, important and nontrivial information from a database. Sequential Pattern Mining is a data mining technique that aims to obtain and analyze frequent subsequences from sequences of events or items with or without time constraint. The importance of a sequence can be measured based on different factors such as the frequency of their occurrence, their length and also their profit. The pattern mining or the discovery of important and unexpected patterns and information was first introduced in 1990 with the well-known Apriori algorithm. Then, and after many studies on frequent pattern mining, a new approach appeared: Sequential Pattern Mining. …