Search results for "APT"
showing 10 items of 5479 documents
Memory CD8+ T Cell Protection From Viral Reinfection Depends on Interleukin-33 Alarmin Signals
2019
Memory CD8+ cytotoxic T lymphocytes (CTLs) can protect against viral reinfection. However, the signals driving rapid memory CTL reactivation have remained ill-defined. Viral infections can trigger the release of the alarmin interleukin-33 (IL-33) from non-hematopoietic cells. IL-33 signals through its unique receptor ST2 to promote primary effector expansion and activation of CTLs. Here, we show that the transcription factor STAT4 regulated the expression of ST2 on CTLs in vitro and in vivo in primary infections with lymphocytic choriomeningitis virus (LCMV). In the primary antiviral response, IL-33 enhanced effector differentiation and antiviral cytokine production in a CTL-intrinsic manne…
El papel de Boito en la madurez de Verdi: Otello y Falstaff
2015
Tras la composición de Aida y la Messa di Requiem, Verdi daba por concluida su carrera compositiva. Arrigo Boito será quien, con su talento y psicología, consiga que el maestro italiano vuelva a coger la pluma para escribir las que serán sus dos últimas óperas: Otello y Falstaff. Además del brillante trabajo de adaptación que realizará como libretista de ambos trabajos, Boito será quien apoye a Verdi y le dé fuerza en los momentos de debilidad, permitiendo que acabara su carrera superando su sueño frustrado: el éxito de una ópera cómica. After the composition of Aida and Messa di Requiem, Verdi considered that his compositive career had concluded. Arrigo Boito, with his talent and psycholog…
Le rire, clef de voûte du vaudeville
2018
Rire au théâtre. Théâtre comique. Quels sont les facteurs qui font que le texte théâtral soit comique ? Qu’est-ce que le rire ? Quels sont les éléments qui déclenchent cette réaction ? Henry Bergson (1859-1941) l’analyse minutieusement dans son œuvre Le rire (1922), ce qui permet de mieux comprendre certains mécanismes employés par les dramaturges au moment de créer leurs pièces. Une des questions qui se dégagent de l’étude de Bergson est la possibilité que les ingrédients de la recette pour faire rire varient en fonction de la nationalité de celui qui rit, autrement dit, serait-il possible que les bases du rire varient en fonction des différentes cultures ?
Pleasurable and Intersubjectively Embodied Experiences of Electronic Dance Music
2016
How do dancers engage with electronic dance music (EDM) when dancing? This paper reports on an empirical study of dancers' pleasurable engagement with three structural properties of EDM: (1) breakdown, (2) build-up, and (3) drop. Sixteen participants danced to a DJ mix in a club-like environment, and the group’s bodily activity was recorded with an infrared, marker-based motion capture system. After they danced, the subjects filled out questionnaires about the pleasure they experienced and their relative desire to move while dancing. Subsequent analyses revealed associations between the group’s quantity of motion and self-reported experiences of pleasure. Associations were also found betwee…
Measuring Aksak Rhythm and Synchronization in Transylvanian Village Music by Using Motion Capture
2015
<p>Techniques based on motion capture can be useful in <span><span style="font-size: x-small;">analyzing a wide range of musical styles and practices</span></span>: in this case, Transylvanian village music. We focused on a repertoire known as “Gypsy songs of sorrow”, played by professional Gypsy musicians during parties and celebrations of their own community. Two parameters were the object of study: rhythmic duration, and synchronization between musicians (a violinist and a viola player). Results show that rhythm is a local variant of <em>aksak</em> and is based on two duration units (S=short, L=long) which respect the formula 2:3 &lt; S:L &am…
Progenitor death drives retinal dysplasia and neuronal degeneration in a mouse model of Atrip-Seckel syndrome
2020
ABSTRACT Seckel syndrome is a type of microcephalic primordial dwarfism (MPD) that is characterized by growth retardation and neurodevelopmental defects, including reports of retinopathy. Mutations in key mediators of the replication stress response, the mutually dependent partners ATR and ATRIP, are among the known causes of Seckel syndrome. However, it remains unclear how their deficiency disrupts the development and function of the central nervous system (CNS). Here, we investigated the cellular and molecular consequences of ATRIP deficiency in different cell populations of the developing murine neural retina. We discovered that conditional inactivation of Atrip in photoreceptor neurons …
Mismatch negativity (MMN) in freely-moving rats with several experimental controls.
2014
Mismatch negativity (MMN) is a scalp-recorded electrical potential that occurs in humans in response to an auditory stimulus that defies previously established patterns of regularity. MMN amplitude is reduced in people with schizophrenia. In this study, we aimed to develop a robust and replicable rat model of MMN, as a platform for a more thorough understanding of the neurobiology underlying MMN. One of the major concerns for animal models of MMN is whether the rodent brain is capable of producing a human-like MMN, which is not a consequence of neural adaptation to repetitive stimuli. We therefore tested several methods that have been used to control for adaptation and differential exogenou…
La clase de lengua en secundaria como aula de E/LE: cómo aplicar algunas herramientas de L2
2013
El alumnado no nativo en secundaria obligatoria (ESO) requiere una atención y una adaptación curricular específicas, por lo que el profesorado ha de emplear las estrategias necesarias para que pueda adquirir en poco tiempo la lengua vehicular, imprescindible para poder progresar en el resto de materias. La obligatoriedad de este nivel educativo y las exigencias para poder promocionar dificultan el proceso, especialmente a la hora de aplicar los criterios de evaluación y de calificar al alumno. Una alternativa complementaria a la evaluación oficial la constituyen los materiales y herramientas de E/LE, puesto que permiten valorar los progresos lingüísticos del alumno y comprobar el grado de c…
Estrategias de afrontamiento en adultos mayores en función de variables sociodemográficas (Coping strategies in older adults as a function of sociode…
2015
Coping strategies are used to adapt to the changes that occur during aging. This study investigated 275 older adults who attended a senior citizen’s centre. They provided sociodemographic data and answered the Stress Coping Questionnaire (SCQ) in a semistructured interview. The aim was to analyse the use of coping strategies based in several sociodemographic variables, using correlations, t tests, and ANOVAs. The results showed a positive and significant association between age and religion, and differences were found in gender, marital status, educational attainment, and income level. In conclusion, as age increases, religion is most commonly used coping strategy; women make greater use of…
Parallel Adaptation to Spatially Distinct Distortions
2020
Optical distortions as a visual disturbance are inherent in many optical devices such as spectacles or virtual reality headsets. In such devices, distortions vary spatially across the visual field. In progressive addition lenses, for example, the left and right regions of the lens skew the peripheral parts of the wearers visual field in opposing directions. The human visual system adapts to homogeneous distortions and the respective aftereffects are transferred to non-retinotopic locations. This study investigates simultaneous adaptation to two opposing distortions at different retinotopic locations. Two oppositely skewed natural image sequences were presented to 10 subjects as adaptation s…