Search results for "APT"
showing 10 items of 5479 documents
The distributions of protein coding genes within chromatin domains in relation to human disease.
2019
Abstract Background Our understanding of the nuclear chromatin structure has increased hugely during the last years mainly as a consequence of the advances in chromatin conformation capture methods like Hi-C. The unprecedented resolution of genome-wide interaction maps shows functional consequences that extend the initial thought of an efficient DNA packaging mechanism: gene regulation, DNA repair, chromosomal translocations and evolutionary rearrangements seem to be only the peak of the iceberg. One key concept emerging from this research is the topologically associating domains (TADs) whose functional role in gene regulation and their association with disease is not fully untangled. Resul…
Genotype-specific vs. cross-reactive host immunity against a macroparasite
2013
Vertebrate hosts often defend themselves against several co-infecting parasite genotypes simultaneously. This has important implications for the ecological dynamics and the evolution of host defence systems and parasite strategies. For example, it can drive the specificity of the adaptive immune system towards high genotype-specificity or cross-reactivity against several parasite genotypes depending on the sequence and probability of re-infections. However, to date, there is very little evidence on these interactions outside mammalian disease literature. In this study we asked whether genotype-specific or cross-reactive responses dominate in the adaptive immune system of a fish host towards…
Fomentar la resiliencia en familias con enfermedades crónicas pediátricas
2013
En este artículo se describen los diferentes enfoques que se pueden aplicar al estudio del concepto de resiliencia familiar en el contexto de las enfermedades crónicas pediátricas y sus implicaciones en la práctica clínica y educativa. Asimismo, se describen los principios generales que deben regir esta práctica y las actuaciones concretas de los profesionales de los sistemas sanitarios, educativos y sociales. La resiliencia familiar es imprescindible para mantener una buena calidad de vida del niño enfermo y de la familia en su conjunto.
Could Low-Frequency Electromyostimulation Training be an Effective Alternative to Endurance Training? An Overview in One Adult
2014
This preliminary study aimed to investigate the effects of a six-week low-frequency electromyostimulation training (10Hz) on the cardiovascular, respiratory and muscular systems. To that purpose, aerobic capacity, knee extensor muscles strength and architecture, muscle sympathetic nervous activity, blood pressure and heart rate have been evaluated in one healthy male subject (33 year-old, 1.73 m, 73 kg). Results showed improvement of aerobic capacity (+4.5% and +11.5% for maximal oxygen uptake and ventilatory threshold) and muscle strength (+11% and +16% for voluntary and evoked force). Moreover, for the first time, this study demonstrated low-frequency training effects on muscle architectu…
A NEW TOOL FOR THE STUDY OF RESONANCE IN CHEMICAL EDUCATION
2014
The objective of this study is to present a computer-based project, for which our program POLAR and our version of PAPID were written for the study of the subject of resonance in chemistry. Both algorithms allow a better didactic strategy and methodological adaptation for the study of molecular properties in chemical education. Teachers will find the options of POLAR and PAPID useful for demonstrations. It is still to be explored the methodological application of these computational programs enriching the present teaching techniques. Implementing new algorithms in learning situations is technically simple, but checking their usefulness in teaching practice is extraordinarily complex and req…
Policies of Resilience in the New Institutional Process. The Case-Studies of Palermo and Siracusa in the South of Italy
2015
At the end of 2012, the PON METRO National Scheme was set up in Italy, inspired by the EU Urban Agenda. It also allows towns like Palermo to test and reach targets of urban resilience, focusing on mobility and sustainable energy in order to improve life in the cities together with innovative policies of social inclusion. Other medium-sized cities also tried to face the problem of urban resilience without using national funds. The city of Siracusa, for example, made use of EU direct co-financing schemes. This paper aims to analyse the planning projects and measures adopted in Sicily over the past few years in order to examine government approaches focusing on resilience or those that are som…
Measuring self‐regulated learning in a junior high school mathematics classroom : Combining aptitude and event measures in digital learning materials
2023
Background Measurement of students' self-regulation skills is an active topic in education research, as effective assessment helps devising support interventions to foster academic achievement. Measures based on event tracing usually require large amounts of data (e.g., MOOCs and large courses), while aptitude measures are often qualitative and need careful interpretation. Precise and interpretable evaluation of self-regulation skills in a normal K-12 classroom thus poses a challenge. Objectives The present study proposes and explores a learning analytics method of combining aptitude and event measures to evaluate student's self-regulation skills. Methods An explorative learning analytics s…
On developing adaptive vocabulary learning game for children with an early language delay
2018
Vocabulary replenishment is an ordinary child development process. Deviations in this process can significantly affect the further progress and perception of the educational material in the school. A hypothesis was proposed that the similarity of words on various factors can influence the child's understanding. To test this hypothesis in this work, we propose the development of AdapTalk game for children. This game is concentrated on learning words, in the context of animals. The game will create the basis for further testing the influence of the semantic similarity of words for the child. This work describes the development background, the basic principles of calculating the semantic simil…
RNA-Binding Proteins as Epigenetic Regulators of Brain Functions and Their Involvement in Neurodegeneration.
2022
A central aspect of nervous system development and function is the post-transcriptional regulation of mRNA fate, which implies time- and site-dependent translation, in response to cues originating from cell-to-cell crosstalk. Such events are fundamental for the establishment of brain cell asymmetry, as well as of long-lasting modifications of synapses (long-term potentiation: LTP), responsible for learning, memory, and higher cognitive functions. Post-transcriptional regulation is in turn dependent on RNA-binding proteins that, by recognizing and binding brief RNA sequences, base modifications, or secondary/tertiary structures, are able to control maturation, localization, stability, and tr…