Search results for "APT"
showing 10 items of 5479 documents
Radioterapia adaptada a los movimientos fisiológicos. Incertidumbres asociadas
2015
Los movimientos del paciente, de órganos y tumores son la nueva frontera tecnológica para los tratamientos de radioterapia. Con el creciente uso de la radioterapia externa altamente conformada, se ha logrado reducir el tumor mediante la reducción de las incertidumbres geométricas durante el curso del tratamiento. Contabilizando las incertidumbres en la intrafracción (dentro de la misma fracción de tratamiento) e interfracción (entre dos fracciones distintas, generalmente consecutivas, i.e. dos días de tratamiento distintos) asociadas al posicionamiento del paciente, movimientos tumorales (incluidos los movimientos de pulmón e hígado con la respiración) y los cambios entre las 5 y 7 semanas …
Prediction of harmful variants on mitochondrial genes : Test of habitat-dependent and demographic effects in a euryhaline fish
2017
Both effective population size and life history may influence the efficacy of purifying selection, but it remains unclear if the environment affects the accumulation of weakly deleterious nonsynonymous polymorphisms. We hypothesize that the reduced energetic cost of osmoregulation in brackish water habitat may cause relaxation of selective constraints at mitochondrial oxidative phosphorylation (OXPHOS) genes. To test this hypothesis, we analyzed 57 complete mitochondrial genomes of Pungitius pungitius collected from brackish and freshwater habitats. Based on inter- and intraspecific comparisons, we estimated that 84% and 68% of the nonsynonymous polymorphisms in the freshwater and brackish …
Landslide susceptibility zonation by exploiting GIS tools and two statistical methods: binary logistic regression and multivariate adaptive regressio…
2013
In the recent years advanced statistical methods and GIS tools have been frequently used to assess landslide susceptibility. The latter is estimated by establishing statistical relationships between landscape characteristics and spatial distribution of past slope-failures. These are mapped mainly by recognizing changes on slope morphology produced by gravity. Despite of this, most of the researches on landslide susceptibility do not consider that slope-failures modify topography and associate high probability of landsliding with topographic characteristics that differ from those that led slope-failures. In this research we analyzed landslide susceptibility in the basin of the Malvello river…
Assessment of Gully Erosion Susceptibility Using Multivariate Adaptive Regression Splines and Accounting for Terrain Connectivity
2017
In this work, we assessed gully erosion susceptibility in two adjacent cultivated catchments of Sicily (Italy) by employing multivariate adaptive regression splines and a set of geo-environmental variables. To explore the influence of hydrological connectivity on gully occurrence, we measured the changes of performance occurred when adding one by one nine predictors reflecting terrain connectivity to a base model that included contributing area and slope gradient. Receiver operating characteristic (ROC) curves and the area under the ROC curve were used to evaluate model performance. Gully predictive models were trained in both the catchments and submitted to internal (in the calibration cat…
Predicting Earthquake-Induced Landslides by Using a Stochastic Modeling Approach: A Case Study of the 2001 El Salvador Coseismic Landslides
2023
In January and February 2001, El Salvador was hit by two strong earthquakes that triggered thousands of landslides, causing 1259 fatalities and extensive damage. The analysis of aerial and SPOT-4 satellite images allowed us to map 6491 coseismic landslides, mainly debris slides and flows that occurred in volcanic epiclastites and pyroclastites. Four different multivariate adaptive regression splines (MARS) models were produced using different predictors and landslide inventories which contain slope failures triggered by an extreme rainfall event in 2009 and those induced by the earthquakes of 2001. In a predictive analysis, three validation scenarios were employed: the first and the second …
Psychological variables and temporomandibular disorders: distress, coping, and personality.
2004
Abstract Objective This study analyzes the psychological variables of distress, personality, and coping that are related to the diagnosis based on the Research Diagnostic Criteria for temporomandibular disorder. Study design An age and sex-matched controlled study conducted with a convenience sample (n = 89) in a tertiary care facility. Results The MANCOVA between the muscular (n = 47), articular (n = 42), and control groups (n = 100) showed that the muscular group differed from the control group, obtaining higher levels of distress, anxiety, and depression, and minor use of positive reinterpretation and humor as coping strategies; the articular group also showed higher distress, less posit…
The role of innate and lymphoid IL-22-producing cells in the immunopathology of primary Sjögren's syndrome
2014
In primary Sjögren's syndrome (pSS) a complex of interconnections between epithelial barrier, innate and adaptive immunity occurs. IL-22 is a pleiotropic cytokine that in pSS may be placed at the intersection of the adaptive and innate branches of immunity. Some evidence suggests that, in pSS, IL-22 may play a prominent pro-inflammatory role driving the early phase of tissue and systemic inflammation and participating in the self-perpetuation of disease. Despite contradictory data in literature about the role of NK cells in pSS, recent data also suggest an important contribution of this subset of cells of the innate immune system in the development and perpetuation of inflammation. Here, we…
Mechanical activity of small and large intestine in normal and mdx mice: a comparative analysis.
1999
The aim of this study was to compare the motor pattern (recorded as changes in intraluminal pressure) of isolated duodenum and proximal colon between dystrophic mdx and normal mice. When duodenal recordings from control preparations were compared with mdx mice there was no significant difference in the spontaneous motor pattern, responses to electrical nerve stimulation or sensitivity to pharmacological agents. Colonic segments from mdx mice showed a more complex motor pattern, consisting of contractions with amplitude and frequency similar to those of controls and by additional contractions with lower amplitude and higher frequency. Moreover, 70% of the colonic preparations from mdx mice d…
Mechanical loading influences the lumbar intervertebral disc. A cross-sectional study in 308 athletes and 71 controls.
2020
There is evidence in animal populations that loading and exercise can positively impact the intervertebral disc (IVD). However, there is a paucity of information in humans. We examined the lumbar IVDs in 308 young athletes across six sporting groups (baseball, swimming, basketball, kendo, soccer, and running; mean age 19 years) and 71 nonathletic controls. IVD status was quantified via the ratio of IVD to vertebral body height (IVD hypertrophy) and ratio of signal intensity in the nucleus to that in the annulus signal (IVD nucleus hydration) on sagittal T2-weighted magnetic resonance imaging. P values were adjusted via the false discovery rate method to mitigate false positives. In examinin…
Duodenal contractile activity in dystrophic (mdx) mice: reduction of nitric oxide influence.
2003
The present study was undertaken to analyse duodenal contractility in adult dystrophic (mdx) mice. The spontaneous changes of the isometric tension and the responses of longitudinal duodenal muscle to nonadrenergic, noncholinergic (NANC) nerve stimulation and to exogenous drugs were compared between normal and mdx mice. Duodenal segments from mdx mice displayed spontaneous contractions with higher frequency than normals. N omega-nitro-L-arginine methyl ester (L-NAME) increased the frequency of contractions in normals without affecting that in mdx mice. In normals, NANC nerve stimulation elicited a transient relaxation abolished by L-NAME. In mdx mice a frank relaxation was not observed, the…