Search results for "APT"
showing 10 items of 5479 documents
Religiosity and social support in Polish older adults: the mediating role of wisdom. Perspectives on Lars Tornstam’s theory of gerotranscendence
2021
Objectives: The purpose of this study was to examine whether wisdom is a mediator in the relation-ships between religious meaning system and social support among older adults. According to the theory of gerotranscendence, associations of religiousness and social support are complex and sug- gest the existence of wisdom in their internal structures. Method: The study included 466 persons aged 50–75. Three measures were used: Religious Meaning System Scale (RMSS), Three-Dimensional Wisdom Scale (3D-WS) and Berlin Social Support Scales (BSSS). Results: The analyses allowed for a partial verification of the hypothesis that wisdom is a mediator in the relationship between the religious meaning s…
Metabolic Reprogramming of Innate Immune Cells as a Possible Source of New Therapeutic Approaches in Autoimmunity.
2022
Immune cells undergo different metabolic pathways or immunometabolisms to interact with various antigens. Immunometabolism links immunological and metabolic processes and is critical for innate and adaptive immunity. Although metabolic reprogramming is necessary for cell differentiation and proliferation, it may mediate the imbalance of immune homeostasis, leading to the pathogenesis and development of some diseases, such as autoimmune diseases. Here, we discuss the effects of metabolic changes in autoimmune diseases, exerted by the leading actors of innate immunity, and their role in autoimmunity pathogenesis, suggesting many immunotherapeutic approaches.
Estudio del mecanismo de reacción e inhibición de cisteína proteasas mediante métodos multiescala
2022
En esta tesis doctoral se realizaron estudios computacionales para las enzimas caspasa-1 y la 3CLpro del SARS-CoV-2. Estas enzimas pertenecen a la familia de las cisteína proteasas, las cuales hidrolizan sus respectivos sustratos rompiendo un enlace peptídico en particular. En esta reacción interviene una diada catalítica conformada por un par Cis-His. La caspasa-1 fue seleccionada debido a su importancia farmacológica en la enfermedad de Alzheimer, y la enzima 3CLpro del SARS-CoV-2 por estar involucrada en el proceso de replicación del virus responsable de la enfermedad del COVID-19. Para ambas se realizaron estudios que ayudaron a racionalizar el mecanismo de reacción con su sustrato natu…
Le récitatif entre espace périphérique et décrochage déictique du texte
2022
This article explores the issues at stakes in defining the narrative caption. As a starting point, it reviews usual definitions which combine a functional component (the caption provides a certain kind of information), a graphic component (that characterizes it as a space) and an enunciative component (the text which conveys the narrator’s voice) are combined. The article distingues between two objects: on the one hand the text box as a peripheral space in relation to the panel, on the other hand the caption as a textual element. In order to avoid the disputed concept of narrator and to include a wider set of texts, the caption as a text is defined by its lack of deictic anchoring in the im…
Tiesvedības apturēšana civilprocesā.
2018
Maģistra darbā “Tiesvedības apturēšana civilprocesā” pētīts Latvijas Republikas Civilprocesa likumā regulētais tiesvedības apturēšanas institūts un tā piemērošanas problemātika, kā arī darba nobeigumā aplūkots Civilprocesa likumā nepārņemtais “blakus procesa” jēdziens, kura izpratne un iespējama expressis verbis ieviešana Civilprocesa likumā varētu būt lietderīga, lai veicinātu izpratni par apturētā tiesvedībā blakus procesa kārtībā izskatāmajiem jautājumiem. Proti, tādiem jautājumiem, kas nav saistīti ar lietu pēc būtības, bet kuru izskatīšana bez liekas kavēšanās ir nepieciešama tiesvedībā iesaistīto pušu tiesību uz taisnīgu tiesu nodrošināšanai. Darba ietvaros ir izpētīts tiesvedības apt…
APT Cyber-attack Modelling: Building a General Model
2022
The global community continues to experience an increase in the scale, sophistication, and successful perpetration of cyber-attacks. As the quantity and value of electronic information have increased, so too have the efforts of criminals and other malicious actors who have embraced the Internet as a more anonymous, convenient, and profitable way of carrying out their activities. The systems are attacked more and more by single or multiple hacktivists, state sponsored hackers, cyber criminals, cyber terrorists, cyber spies, or cyber warfare warfighters. The cyber security approach requires a balance of cyber threat intelligence, real time cyber-attack detection and especially the cyber early…
Carbon Nitride-Based Catalysts for High Pressure CO2 Photoreduction
2022
In the current research, the productivity of CO2 photoreduction has been boosted by performing the reaction in an innovative photocatalytic reactor, which allows for operation up to 20 bar. A set of photocatalysts were used, including three types of pristine TiO2, i.e., one commercially prepared (Evonik P25), one home-prepared by flame spray pyrolysis (FSP), and one obtained by the hydrolysis of TiCl4 (TiO2exCl), a bare thermo-exfoliated carbon nitride (C3N4-TE), and binary materials composed of TiO2 and C3N4-TE. The photoreduction was carried out in water at pH 14 and in the presence of Na2SO3 as a hole scavenger. Hydrogen and very small amounts of CO were detected in the head space of the…
The roles of linguistic confidence and integrative motivation on cross-cultural adaptation of Asian degree students Finland
2015
While cross-cultural adaptation of international students has become more and more popular topics in the field of intercultural communication, there are few studies related to students who come to non-native-English-speaking countries to study international programs. Specifically, the number of Asian students enrolling in international degree programs in Finland has been increasing recently. Besides other difficulties, language has become one of the most baffling issues in the process of both sociocultural adaptation and psychological adaptation of strangers in the host country (Maza, 1963). By narrowing the impacts of integrative motivation and linguistic confidence, they have drawn some r…
Specific Emotional Reactions to Tonal Music - Indication of the Adaptive Character of Tonality Recognition
2013
People report that specific emotional reactions accompany the perception of tonal relations during listening to tonal music. These reactions are not restricted only to people living in the Western culture. Different types of tonality which are observed in all musical cultures seem to evoke similarly strong emotional reactions. The emotional response to a tonal sound sequence has been predominantly explained by fulfilling or not the pitch-related expectations of listeners. However, although this model indicates the general mechanism of prediction as the main source of an emotional reaction, it does not explain why the musical pitch-related expectation causes a stronger emotional reaction tha…
r Process (n, γ) Rate Constraints from the γ Emission of Neutron Unbound States in β decay
2017
Total absorption gamma-ray spectroscopy is used to measure accurately the intensity of γγ emission from neutron-unbound states populated in the ββ-decay of delayed-neutron emitters. From the comparison of this intensity with the intensity of neutron emission a constraint on the (n, γγ) cross section for highly unstable neutron-rich nuclei can be deduced. A surprisingly large γγ branching was observed for a number of isotopes which might indicate the need to increase by a large factor the Hauser-Feshbach (n, γγ) cross-section estimates that impact on r process abundance calculations. peerReviewed