Search results for "ARCHITECTURE"
showing 10 items of 3706 documents
Supporting fine-grained generative model-driven evolution
2010
Published version of an article in the journal: Software and Systems Modeling. Also available on SpringerLink:http://dx.doi.org/10.1007/s10270-009-0144-1 In the standard generative Model-driven Architecture (MDA), adapting the models of an existing system requires re-generation and restarting of that system. This is due to a strong separation between the modeling environment and the runtime environment. Certain current approaches remove this separation, allowing a system to be changed smoothly when the model changes. These approaches are, however, based on interpretation of modeling information rather than on generation, as in MDA. This paper describes an architecture that supports fine-gra…
An Innovative Structural Dynamic Identification Procedure Combining Time Domain OMA Technique and GA
2022
In this paper an innovative and simple Operational Modal Analysis (OMA) method for structural dynamic identification is proposed. It combines the recently introduced Time Domain–Analytical Signal Method (TD–ASM) with the Genetic Algorithm (GA). Specifically, TD–ASM is firstly employed to estimate a subspace of candidate modal parameters, and then the GA is used to identify the structural parameters minimizing the fitness value returned by an appropriately introduced objective function. Notably, this method can be used to estimate structural parameters even for high damping ratios, and it also allows one to identify the Power Spectral Density (PSD) of the structural excitat…
Genetic variability at neutral markers, quantitative trait loci and trait in a subdivided population under selection
2003
Abstract Genetic variability in a subdivided population under stabilizing and diversifying selection was investigated at three levels: neutral markers, QTL coding for a trait, and the trait itself. A quantitative model with additive effects was used to link genotypes to phenotypes. No physical linkage was introduced. Using an analytical approach, we compared the diversity within deme (HS) and the differentiation (FST) at the QTL with the genetic variance within deme (VW) and the differentiation (QST) for the trait. The difference between FST and QST was shown to depend on the relative amounts of covariance between QTL within and between demes. Simulations were used to study the effect of se…
Genetic Diversity and Evolution of Viral Populations
2021
Abstract Population genetic diversity plays a prominent role in viral evolution, pathogenesis, immune escape, and drug resistance. Different mechanisms are responsible for creating and maintaining genetic diversity in viruses, including error-prone replication, repair avoidance, and genome editing, among others. This diversity is subsequently modulated by natural selection and random genetic drift, whose action in turn depends on multiple factors including viral genetic architecture, viral demography, and ecology. Understanding these processes should contribute to the development of more efficient control and treatment strategies against viral pathogens.
Causes of the genetic architecture of south-west European high mountain disjuncts
2008
Background: Postglacial climatic warming in south-western Europe and the retreat of cold-adapted species into higher elevations, starting in the Sierra Nevada and proceeding northwards to the Pyrenees and Alps, should have resulted in a pattern of ‘successive vicariance’. Alternatively, long-distance dispersal might explain the extant distribution pattern of mountain species in this region. Aims: Here, we report an investigation of two alpine plants, Saxifraga oppositifolia and S. stellaris, which co-occur in the Sierra Nevada, the Pyrenees, and the south-western Alps/Massif Central. Our aim was to distinguish between (successive) vicariance and long-distance dispersal as alternative explan…
Genome wide association analysis in dilated cardiomyopathy reveals two new key players in systolic heart failure on chromosome 3p25.1 and 22q11.23
2020
SummaryWe present the results of the largest genome wide association study (GWAS) performed so far in dilated cardiomyopathy (DCM), a leading cause of systolic heart failure and cardiovascular death, with 2,719 cases and 4,440 controls in the discovery population. We identified and replicated two new DCM-associated loci, one on chromosome 3p25.1 (lead SNP rs62232870, p = 8.7 × 10−11 and 7.7 × 10−4 in the discovery and replication step, respectively) and the second on chromosome 22q11.23 (lead SNP rs7284877, p = 3.3 × 10−8 and 1.4 × 10−3 in the discovery and replication step, respectively) while confirming two previously identified DCM loci on chromosome 10 and 1, BAG3 and HSPB7. The genetic…
The Sea Urchin sns5 Chromatin Insulator Improves the Likelihood of Lentiviral Vectors in Erythroid Milieu By Organizing an Independent Chromatin Doma…
2015
Abstract Retroviral vectors are currently the most suitable vehicles for therapeutic gene transfer in hematopoietic stem cells. However, these vectors are known to integrate rather randomly throughout the genome, suffering the so called chromosomal position effects (PE). Such a critical occurrence most probably depends upon the ability of heterochromatin to spread in the inserted vector sequences. Moreover, the use of transgenes imply genotoxicity effects, since the cis-regulatory sequences harbored by the vector can disturb the proper transcription of the resident genes neighboring the integration site, potentially leading to malignant transformation. Due to their enhancer blocker activity…
“Misura/Relazione. Area Porta Ovest"
2010
The paper describes the different phases of the project experience faced during the INTERNATIONAL PhD SUMMER SCHOOL: STRATEGY RESEARCH PROJECTS FOR THE CONTEMPORARY CITY. TALL BUILDINGS AND LANDSCAPE. The construction of the landscape through the composition of the figure; the relationship of the tall building with its context; and, finally, the definition of the elements of the tall building consisting of the plinth, the central body, and the crowning.
Visualization of the Renewable Energy Resources
2016
The methods of the renewable energy resources visualization are analysed in this work, the examples of the systems and possible architecture of the renewable energy monitoring systems of the Republic of Kazakhstan are considered. Successful practices are analysed, the leading scientific organization in the field of green energy are considered, a comparative analysis of geographic information systems and data sources in the field of green energy is performed. Possible software architecture of the system based on 3M paradigm of geographic information system (multilayer views, multilayer architecture and multi-agent interaction) is considered.
The spatial dimension of the French private rental markets: Evidence from microgeographic data in 2015
2021
International audience; This article draws on data collected by local rental observatories in 12 French urban units in 2015 to analyze the spatial dimension of hedonic rental prices in the private rental market through (i) the spatial heterogeneity between urban units and (ii) the wide variety of contextual and locational characteristics (socio-economic, environmental (dis)amenity, and accessibility) and flexible specifications to capture their potential non-linear influence on rent. Based on a joint test of equality of coefficients across all urban units, we find that hedonic prices differ for 75% of the characteristics, thereby justifying a detailed analysis of heterogeneity. Lyon, Nice, …