Search results for "ARM"
showing 10 items of 19046 documents
Increasing Yield and Antioxidative Performance of Litchi Pericarp Procyanidins in Baked Food by Ultrasound-Assisted Extraction Coupled with Enzymatic…
2018
Extraction with organic solvents is a traditional method to isolate bioactive compounds, which is energy-wasting and time-consuming. Therefore, enzyme and ultrasound treatments were combined to assist the extraction of oligomeric procyanidins from litchi pericarp (LPOPC), as an innovative approach to replace conventional extraction methods. Under optimum conditions (enzyme concentration 0.12 mg/mL, ultrasonic power 300 W, ultrasonic time 80 min, and liquid/solid ratio 10 mL/g), the yield of LPOPC could be improved up to 13.5%. HPLC analysis indicated that the oligomeric procyanidins (OPC) content of LPOPC from proposed extraction was up to 89.6%, mainly including (&minus
The role of SAXS and molecular simulations in 3D structure elucidation of a DNA aptamer against lung cancer
2021
Aptamers are short, single-stranded DNA or RNA oligonucleotide molecules that function as synthetic analogs of antibodies and bind to a target molecule with high specificity. Aptamer affinity entirely depends on its tertiary structure and charge distribution. Therefore, length and structure optimization are essential for increasing aptamer specificity and affinity. Here, we present a general optimization procedure for finding the most populated atomistic structures of DNA aptamers. Based on the existed aptamer LC-18 for lung adenocarcinoma, a new truncated LC-18 (LC-18t) aptamer LC-18t was developed. A three-dimensional (3D) shape of LC-18t was reported based on small-angle X-ray scattering…
Qualitative comparision of olive oil mediterranean
2012
Desarrollo de un sistema de detección de mutaciones somáticas de interés clínico meciante secuenciación masiva en muestras oncológicas
2018
DESARROLLO DE UN SISTEMA DE DETECCIÓN DE MUTACIONES SOMÁTICAS DE INTERÉS CLÍNICO MEDIANTE SECUENCIACIÓN MASIVA EN MUESTRAS ONCOLÓGICAS INTRODUCCIÓN. La descripción de los mecanismos moleculares de algunos de los tumores más frecuentes ha permitido el desarrollo de nuevos fármacos capaces de antagonizar moléculas propias de los tumores. Esto implica la necesidad de determinar la existencia de determinadas alteraciones génicas cuya presencia va asociada a la decisión terapéutica en el uso de estos fármacos. Por lo que ha sido necesario el desarrollo de técnicas de análisis genético que sean lo suficientemente sensibles para detectar la presencia de mutaciones somáticas de interés clínico, a l…
FITOVIGILANZA: INTERAZIONI FARMACO-FITOTERAPICI IN PAZIENTI ONCOLOGICI ED IMMUNOCOMPROMESSI
2012
Protective ventilation with high versus low positive end-expiratory pressure during one-lung ventilation for thoracic surgery (PROTHOR): study protoc…
2019
Background: Postoperative pulmonary complications (PPC) may result in longer duration of in-hospital stay and even mortality. Both thoracic surgery and intraoperative mechanical ventilation settings add considerably to the risk of PPC. It is unclear if one-lung ventilation (OLV) for thoracic surgery with a strategy of intraoperative high positive end-expiratory pressure (PEEP) and recruitment maneuvers (RM) reduces PPC, compared to low PEEP without RM. Methods: PROTHOR is an international, multicenter, randomized, controlled, assessor-blinded, two-arm trial initiated by investigators of the PROtective VEntilation NETwork. In total, 2378 patients will be randomly assigned to one of two diffe…
Avoimen tiedon virrassa
2016
Role of acetaldehyde in alcohol addiction: current evidence and future perspectives
2011
The effects of alcohol have been widely studied during the past century, corroborating the idea that this tiny chemical compound acts throughout most of our neurotransmitter systems since it is capable of inducing addictive behaviour. Two of the most serious problems of alcohol addiction are craving and relapse; several studies have demonstrated that relapse is related to the anxious state which occurs during withdrawal, and it has been proved that this behavioural modifications results from an alteration of the dopaminergic and serotonergic systems. An important role in the neurobiology of alcohol addiction is played by acetaldehyde (ACD), ethanol first metabolite. Our recent studies indee…
Modulation of alcohol consumption using an operant self-administration paradigm: effects of a new dopamine aminoacidic conjugate, Phenylalanine-β(3,4…
2014
Rewarding and reinforcing properties of alcohol have been shown to be mediated by activation of the mesolimbic dopaminergic system. Experimental evidences suggest that mesolimbic dopamine system is hypofunctional in addicted brain; further, reduced dopaminergic activity outlasts somatic signs of withdrawal and may drive craving and relapse. Boosting strategy on dopaminergic neurons could represent a valid therapy. Effects of pharmacological manipulation of brain Dopaminergic receptors by a new dopamine conjugate, Phenylalanine-β(3,4dihydroxyphenyl)-etilamide (DA-Phen), on operant behaviour and on both acute and prolonged withdrawal symptoms during ethanol abstinence have been evaluated. Mal…
Vuorovaikutus opettajaksi opiskelevien asiantuntijuudessa
2009
Opettajan työssä vuorovaikutus on olennainen osa asiantuntijaosaamista. Työ toteutuu enimmäkseen vuorovaikutussuhteissa oppijoiden, opettajien, koulun muun henkilökunnan, vanhempien ja muiden sidosryhmien kanssa. Työssä korostuvat yhteistoiminta ja yhteisöllisyys: opettajan asiantuntijuus on vahvasti vuorovaikutusprosesseihin, -suhteisiin ja niihin osallistumiseen liittyvä ilmiö. Vuorovaikutuksen ja asiantuntijuuden yhteyden ymmärtäminen ei ole kuitenkaan itsestään selvää. Näin ollen on tärkeää tarkastella, miten opettajaksi opiskelevat näkevät vuorovaikutuksen merkityksen oman kehittyvän asiantuntijuutensa toteutumisessa. Tässä artikkelissa tarkastellaan, millaisia merkityksiä luokanopetta…