Search results for "ARS"
showing 10 items of 5947 documents
Virtudes escolares percibidas por estudiantes y docentes ecuatorianos: diferencias según sexo, establecimiento y roles
2020
El objetivo del estudio es evaluar la virtuosidad percibida en organizaciones escolares y las diferencias por tipo de centro educativo (fiscal, municipal); sexo (mujer, hombre) y rol (estudiantes, docentes). Se trató de un estudio instrumental basado en el análisis de la estructura factorial y la fiabilidad de un cuestionario para evaluar virtudes percibidas en escuelas (VPOE); y, de un estudio descriptivo transversal que analizó diferencias por sexo, rol y tipo de organizaciones escolares con relación a las virtudes percibidas. Se trabajó con una muestra de 550 estudiantes (49.28 % mujeres) y 105 docentes (47.62% mujeres). El análisis factorial determinó un modelo de cuatro factores que pe…
IgA-Dominant Infection-Associated Glomerulonephritis Following SARS-CoV-2 Infection
2021
The renal involvement of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been reported. The etiology of kidney injury appears to be tubular, mainly due to the expression of angiotensin-converting enzyme 2, the key joint receptor for SARS-CoV-2; however, cases with glomerular implication have also been documented. The multifactorial origin of this renal involvement could include virus-mediated injury, cytokine storm, angiotensin II pathway activation, complement dysregulation, hyper-coagulation, and microangiopathy. We present the renal histological findings from a patient who developed acute kidney injury and de novo nephrotic syndrome, highly suggestive of acute IgA-domina…
Immune responses during COVID-19 infection
2020
International audience; Over the past 16 years, three coronaviruses (CoVs), severe acute respiratory syndrome CoV (SARS-CoV) in 2002, Middle East respiratory syndrome CoV (MERS-CoV) in 2012 and 2015, and SARS-CoV-2 in 2020, have been causing severe and fatal human epidemics. The unpredictability of coronavirus disease-19 (COVID-19) poses a major burden on health care and economic systems across the world. This is caused by the paucity of in-depth knowledge of the risk factors for severe COVID-19, insufficient diagnostic tools for the detection of SARS-CoV-2, as well as the absence of specific and effective drug treatments. While protective humoral and cellular immune responses are usually m…
Molecular Basis of SARS-CoV-2 Nsp1-Induced Immune Translational Shutdown as Revealed by All-Atom Simulations.
2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic represents the most severe global health crisis in modern human history. One of the major SARS-CoV-2 virulence factors is nonstructural protein 1 (Nsp1), which, outcompeting with the binding of host mRNA to the human ribosome, triggers a translation shutdown of the host immune system. Here, microsecond-long all-atom simulations of the C-terminal portion of the SARS-CoV-2/SARS-CoV Nsp1 in complex with the 40S ribosome disclose that SARS-CoV-2 Nsp1 has evolved from its SARS-CoV ortholog to more effectively hijack the ribosome by undergoing a critical switch of Q/E158 and E/Q159 residues that perfects Nsp1's interactions…
STAT1 and Its Crucial Role in the Control of Viral Infections
2022
The signal transducer and activator of transcription (STAT) 1 protein plays a key role in the immune response against viruses and other pathogens by transducing, in the nucleus, the signal from type I, type II and type III IFNs. STAT1 activates the transcription of hundreds of genes, some of which have been well characterized for their antiviral properties. STAT1 gene deletion in mice and complete STAT1 deficiency in humans both cause rapid death from severe infections. STAT1 plays a key role in the immunoglobulin class-switch recombination through the upregulation of T-bet; it also plays a key role in the production of T-bet+ memory B cells that contribute to tissue-resident humoral memory…
SARS-CoV-2 envelope protein topology in eukaryotic membranes
2020
Coronavirus E protein is a small membrane protein found in the virus envelope. Different coronavirus E proteins share striking biochemical and functional similarities, but sequence conservation is limited. In this report, we studied the E protein topology from the new SARS-CoV-2 virus both in microsomal membranes and in mammalian cells. Experimental data reveal that E protein is a single-spanning membrane protein with the N-terminus being translocated across the membrane, while the C-terminus is exposed to the cytoplasmic side (Nt lum /Ct cyt ). The defined membrane protein topology of SARS-CoV-2 E protein may provide a useful framework to understand its interaction with other viral and ho…
Pràctiques d'Optometria II. Tema 1
2021
El document forma part dels materials docents programats mitjançant l'ajut del Servei de Política Lingüística de la Universitat de València. El tema 1 fa una introducció general de les pràctiques d'optometria II a on es descriu el material a utilitzar, seqüència de les pràctiques i el procediment per a fer les proves optomètriques. Chapter 1 provides a general introduction to the optometry II practices, where the material, the sequence of the practices and the procedure to perform the optometric tests are described.
Pràctiques d'Optometria II. Tema 2
2021
El document forma part dels materials docents programats mitjançant l'ajut del Servei de Política Lingüística de la Universitat de València. El tema 2 descriu com fer la història del cas, les proves preliminars i l'equilibri biocular en l'examen de la visió binocular. Chapter 2 describes how to make case history, preliminary tests, and biocular balance in the examination of binocular vision.
Pràctiques d'Optometria II. Tema 3
2021
El document forma part dels materials docents programats mitjançant l'ajut del Servei de Política Lingüística de la Universitat de València El tema 3 descriu com fer l'estudi de la capacitat de la fusió plana (anàlisi de la supressió) i l’avaluació de la visió de relleu o estereòpsia en l'examen de la visió binocular. Chapter 3 describes how to study the capacity of flat fusion (suppression analysis) and the assessment of relief vision or stereopsis in the examination of binocular vision.
Pràctiques d'Optometria II. Tema 8
2021
El document forma part dels materials docents programats mitjançant l'ajut del Servei de Política Lingüística de la Universitat de València. Aquest guió de pràctiques descriu com fer una teràpia de la visió. S’analitza la selecció del cas, la seqüència de rehabilitació apropiada, i la motivació i compliment del pacient. This chapter describes how to perform vision therapy. The selection of the case, the appropriate rehabilitation sequence, and the motivation and compliance of the patient are analyzed.