Search results for "ASBESTO"
showing 10 items of 21 documents
Symptom burden in mesothelioma patients admitted to home palliative care
2016
Context: Mesothelioma is a very aggressive cancer that is brought on by asbestos exposure. Because there is a long latency period between exposure to asbestos and symptoms of disease, most patients with mesothelioma present with advanced disease and survive an average of 8â12 months. Thus, best supportive care should be considered critical to optimally manage these patients. Aim: The aim of this study was to examine the epidemiological characteristics and symptom burden of mesothelioma patients when admitted to home palliative care. Methods: The charts of a consecutive sample of patients admitted to the home palliative care program with a diagnosis of mesothelioma in an endemic industrial…
Plasmatic extracellular vesicle microRNAs in malignant pleural mesothelioma and asbestos-exposed subjects suggest a 2-miRNA signature as potential bi…
2017
Background Malignant Pleural Mesothelioma (MPM) is an aggressive cancer mainly caused by asbestos exposure and refractory to current therapies. Specific diagnostic markers for early MPM diagnosis are needed. Changes in miRNA expression have been implicated in several diseases and cancers, including MPM. We examined if a specific miRNA signature in plasmatic extracellular vesicles (EV) may help to discriminate between malignant pleural mesothelioma patients (MPM) and subjects with Past Asbestos Exposure (PAE). Methodology/Principal findings We investigated 23 MPM patients and 19 cancer-free subjects with past asbestos exposure (PAE). We screened 754 miRNAs in plasmatic EVs by OpenArray and f…
Diagnostic and prognostic value of three micrornas in environmental asbestiform fibers-associated malignant mesothelioma
2021
Fluoro-edenite (FE) is an asbestiform fiber identified in Biancavilla (Sicily, Italy). Environmental exposure to FE has been associated with a higher incidence of malignant mesothelioma (MM). The present study aimed to validate the predicted diagnostic significance of hsa-miR-323a-3p, hsa-miR-101-3p, and hsa-miR-20b-5p on a subset of MM patients exposed to FE and matched with healthy controls. For this purpose, MM tissues vs. nonmalignant pleura tissues were analyzed through droplet digital PCR (ddPCR) to evaluate differences in the expression levels of the selected miRNAs and their MM diagnostic potential. In addition, further computational analysis has been performed to establish the corr…
Patologie asbesto-correlate osservate a Palermo e Provincia tra lavoratori esposti ad amianto [Asbestos-related diseases observed in Palermo (Italy) …
2011
È stato realizzato uno studio su lavoratori professionalmente esposti ad amianto con l'obiettivo di esaminare i casi di patologia asbesto-correlata nella Provincia di Palermo tra il 2005 e il 2009. I dati sono stati raccolti dalle cartelle cliniche e dai verbali delle deleghe di indagine da parte delle Procure di Palermo e di Termini Imerese al Servizio di Prevenzione e Sicurezza negli Ambienti di Lavoro dell'Azienda Sanitaria Provinciale (ASP 6) di Palermo. La regressione logistica multinomiale evidenzia una associazione significativa tra fumo di tabacco e carcinoma polmonare e tra coloro che hanno cominciato a lavorare precocemente e la presenza di asbestosi e placche pleuriche. La casist…
Production of reactive oxygen intermediates by human macrophages exposed to soot particles and asbestos fibers and increase in NF-kappa B p50/p105 mR…
1999
Alveolar macrophages (AM) play a decisive role in the immunologic defense system of the lung and in inflammatory pulmonary pathomechanisms. AM and blood monocytes (BM) were exposed to chrysotile B, soot FR 101, and Printex 90 (P 90). We evaluated the reactive oxygen intermediate (ROI) release of AM and BM after particle exposure. ROI release was measured by chemiluminescence. Thirty-minute exposure caused a significant (up to 2.5-fold) increase in ROI release of AM (100 micrograms/10(6) cells) compared with control experiments (p0.01). Identical exposure conditions for BM resulted in a similar reaction pattern (maximum 2.2-fold increase in ROI release; p0.05). After a 90-min particle exposu…
Zytopathologische Ergussdiagnostik in der berufsgenossenschaftlichen Begutachtung von Asbest-assoziierten malignen Mesotheliomen und Lungenkarzinomen
2014
Pleural effusion often represents the first clinical symptom of lung carcinoma and malignant mesothelioma. As pleural punctation is performed quite early in the diagnostic procedure, effusion cytology frequently gives the first evidence about the presence of tumour cells and tumor histogenesis. In this study, we report on seven cases which were evaluated in our institution for the Employers' Liability Insurance Association, based solely on cytology findings.The mean age of the seven patients with a given long-term asbestos exposure during their working life was 81.7 years. On average eight smears per patient were investigated. In addition to routine cytology, immunocytochemistry, DNA image …
ASBESTOS-RELATED DISEASES: PENAL, CIVIL AND NATIONAL HEALTH INSURANCE RESPONSIBILITY ACCORDING TO ITALIAN LAW
2014
In this commentary, the authors describe the most important and current issues about the responsibility in asbestos-related diseases according to the Italian Law. In particular, the authors comment the principal implications of Penal, Civil and National Health Insurance laws on occupational and preventive medicine. This brief report represents an useful tool for medical doctor specialists in Occupational, Public Health and Forensic Medicine to support their evaluation of causality in asbestos-related diseases
Biphasic pleural mesothelioma in a electrician working in a railway company: Case report and current trends in mesotheliomas in Italy
2018
Background: Mesothelioma is an aggressive tumour that can involve the pleura, the peritoneum, and sometimes other mesothelia, such as the pericardium and the tunica vaginalis testis. Scientific communities have known for a long time the causal correlation between exposure to asbestos (work related or not) and the onset of the disease (in 75% - 90% of cases) and the increasing number of asbestos-correlated mesotheliomas expected in the next years. Case presentation: The authors present the case of an electrician, 66-year-old man, died for pleural mesothelioma, working in Palermo in the company of the Italian Railways for a period of about 20 years, exposed to asbestos. Frequently he disassem…
Survey sulle patologie asbesto-correlate osservate in una realtà italiana fortemente associata ad esposizione professionale ad amianto.
2011
Obiettivi La Sicilia tra il 1993 ed il 2004 è stata la quinta regione italiana per numero di mesoteliomi. Inoltre, la Provincia di Palermo presenta il maggior numero di casi incidenti in tutta la Regione nel sesso maschile, ed è storicamente caratterizzata da una forte esposizione lavorativa ad amianto (cantieristica navale e ferroviaria). Partendo da questi presupposti, l’obiettivo principale del seguente lavoro è quello di effettuare un’analisi dei casi di asbestosi, placche pleuriche, carcinoma polmonare e mesotelioma asbesto-correlati osservati a Palermo e provincia nel periodo 2005-2009. Metodi Sono stati presi in esame i casi di patologia asbesto-correlata oggetto di delega di indagin…
Reassessing Accuracy Rates of Median Decisions
2007
We show how Bruno de Finetti''s fundamental theorem of prevision has computable applications in statistical problems that involve only partial information. Specifically, we assess accuracy rates for median decision procedures used in the radiological diagnosis of asbestosis. Conditional exchangeability of individual radiologists'' diagnoses is recognized as more appropriate than independence which is commonly presumed. The FTP yields coherent bounds on probabilities of interest when available information is insufficient to determine a complete distribution. Further assertions that are natural to the problem motivate a partial ordering of conditional probabilities, extending the computation …