Search results for "ASEM"

Perlecan Maintains microvessel integrity in vivo and modulates their formation in vitro

2012

Perlecan is a heparan sulfate proteoglycan assembled into the vascular basement membranes (BMs) during vasculogenesis. In the present study we have investigated vessel formation in mice, teratomas and embryoid bodies (EBs) in the absence of perlecan. We found that perlecan was dispensable for blood vessel formation and maturation until embryonic day (E) 12.5. At later stages of development 40% of mutant embryos showed dilated microvessels in brain and skin, which ruptured and led to severe bleedings. Surprisingly, teratomas derived from perlecan-null ES cells showed efficient contribution of perlecan-deficient endothelial cells to an apparently normal tumor vasculature. However, in perlecan…

Intramuscular Extracellular Matrix: Complex Environment of Muscle Cells

2002

KOVANEN, V. Intramuscular extracellular matrix: Complex environment of muscle cells. Exerc. Sport Sci. Rev., Vol. 30, No. 1, pp 20–25, 2002. Different collagen types among other extracellular matrix molecules, remodeling of the extracellular matrix with the aid of matrix metalloproteinases, and inte

Internet of Things : a gateway centric solution for providing IoT connectivity

2016

The Internet of Things (IoT) is revolutionising the traditional Internet by extending it with smart everyday objects. Wearables, smart grids and home automation systems are just a few examples of the IoT. A noteworthy point is that the amount of devices connected to the Internet will rapidly grow with the IoT. The IoT typically involves devices that are constrained in terms of energy, memory and processing resources. Therefore, they also limit applying the existing Internet protocols to the IoT. New protocols have been designed for the IoT, all the way from the physical layer, to the application layer. This thesis presents an implementation for an IoT gateway, which enables connectivity to …

L’iperamilasemia

2008

Toivo Ojala, pedagogi ja museomies : seminaarin ja kasvatusopillisen korkeakoulun lehtori Toivo Ojala jyväskyläläisenä vaikuttajana vuosina 1925-1955

2000

Luottamuksen loppu : konkurssiin ajautuminen ja sen vaikutukset konkurssintekijän elämään Jyväskylän kaupungissa 1870-luvulla

2012

Työssä tarkastellaan mikrohistoriallista lähestymistapaa hyödyntäen konkurssia ja sen kokeneita ihmisiä 1800-luvun jälkipuoliskon Jyväskylässä. Aiempi tutkimus on keskittynyt etenkin rannikkoseutujen suurkauppiaiden taloudellisen toiminnan selvittämiseen, joten työn alueellinen rajaus — pieni ja nuori sisämaan kaupunki — tarjoaa siten erilaisen lähtökohdan tulkinnoille. Toisin kuin useimmiten aikaisemmassa tutkimuksessa, työssä pääosassa ovat menestyjien sijaan taloudellisessa elämässään vaikeuksiin joutuneet ihmiset. Työssä on kyse vararikkoisen selviytymisestä sekä tarkastelusta ennen ja jälkeen. Sosiaalisen pääoman teorian käsitteistön, etenkin luottamuksen ja maineen avulla työssä kysyt…

Jälkeenjätetyt : leskinaiset 1700-luvun lopun jämsäläisessä maalaisyhteisössä

1999

Associations of partnering transition and socioeconomic status with a four-year change in daily steps among Finnish adults

2019

Aim: The aim of this prospective four-year follow-up study was to examine how socioeconomic status (SES) and change in marital status are associated with the change in pedometer-measured physical activity (PA) in adulthood among participants in the ‘Cardiovascular Risk in Young Finns Study’. Methods: Questionnaires were completed and pedometers worn at baseline in 2007 and again at follow-up in 2011 by 1051 Finnish adults (62.3% female, aged 30–45 years in 2007). A latent change score model was used to examine mean change in daily total steps, aerobic steps and non-aerobic steps during weekdays and weekend days between 2007 and 2011. Results: In women re-coupling or finding a new partner wa…

Dystroglycan in Skin and Cutaneous Cells: β-Subunit Is Shed from the Cell Surface

2004

In skin, hemidesmosomal protein complexes attach the epidermis to the dermis and are critical for stable connection of the basal epithelial cell cytoskeleton with the basement membrane (BM). In muscle, a similar supramolecular aggregate, the dystrophin glycoprotein complex links the inside of muscle cells with the BM. A component of the muscle complex, dystroglycan (DG), also occurs in epithelia. In this study, we characterized the expression and biochemical properties of authentic and recombinant DG in human skin and cutaneous cells in vitro. We show that DG is present at the epidermal BM zone, and it is produced by both keratinocytes and fibroblasts in vitro. The biosynthetic precursor is…

α-parvin is required for epidermal morphogenesis, hair follicle development and basal keratinocyte polarity

2020

Epidermal morphogenesis and hair follicle (HF) development depend on the ability of keratinocytes to adhere to the basement membrane (BM) and migrate along the extracellular matrix. Integrins are cell-matrix receptors that control keratinocyte adhesion and migration, and are recognized as major regulators of epidermal homeostasis. How integrins regulate the behavior of keratinocytes during epidermal morphogenesis remains insufficiently understood. Here, we show that alpha-parvin (alpha-pv), a focal adhesion protein that couples integrins to actin cytoskeleton, is indispensable for epidermal morphogenesis and HF development. Inactivation of the murine alpha-pv gene in basal keratinocytes res…