Search results for "ASES"

High-spectral-resolution Fabry-Pérot interferometers overcome fundamental limitations of present volcanic gas remote sensing techniques

2023

Remote sensing (RS) of volcanic gases has become a central tool for studying volcanic activity. For instance, ultraviolet (UV) skylight spectroscopy with grating spectrographs (GS) enables SO2 (and, under favourable conditions, BrO) quantification in volcanic plumes from autonomous platforms at safe distances. These measurements can serve volcanic monitoring and they cover all stages of volcanic activity in long measurement time series, which substantially contributes to the refinement of theories on volcanic degassing. Infrared (IR) remote sensing techniques are able to measure further volcanic gases (e.g., HF, HCl, CO2, CO). However, the employed Fourier transform spectrometers (FTSs) are…

Antitumor Effect of Cabozantinib in Bone Metastatic Models of Renal Cell Carcinoma

2021

Background: The presence of bone metastases in renal cell carcinoma (RCC) negatively affects patients’ survival. Data from clinical trials has highlighted a significant benefit of cabozantinib in bone metastatic RCC patients. Here, we evaluated the antitumor effect of cabozantinib in coculture models of renal cell carcinoma (RCC) and osteoblasts (OBs) to investigate whether and how its antiproliferative activity is influenced by OBs. Methods: Bone/RCC models were generated, coculturing green fluorescent protein (GFP)-tagged Caki-1 and 786-O cells with human primary OBs in a “cell–cell contact” system. RCC proliferation and the OB molecular profile were evaluated after the cabozantinib treat…

Análisis de la procrastinación en estudiantes universitarios

2014

Los estudios realizados en los últimos años destacan que una de las principales conductas inadecuadas en ambientes universitarios es la procrastinación académica, fenómeno cada vez más frecuente pero no por ello mejor comprendido. La procrastinación se considera un retraso innecesario e irracional del inicio o conclusión de las tareas que genera conflicto en el sujeto. Con frecuencia se ha etiquetado como una discrepancia entre “intención” y “acción”, es decir, la distancia entre lo que una persona tiene la intención de hacer y lo que en realidad hace. La procrastinación académica en entornos universitarios y en nuestro contexto cultural no ha recibido hasta la fecha suficiente atención en …

Editorial: Emerging Chemical Risks for Human Health: Endocrine Disruption by Per- and Poly-Fluorinated Alkyl Substances (PFAS).

2021

ITKA111 Oliosuuntautunut analyysi ja suunnittelu

2009

Eco-epidemiology of tick- and rodent-borne pathogens in boreal forests

2017

Infectious diseases are amongst the ten major causes of human mortality worldwide, 60% of them being animal-borne. Variations of abiotic and biotic conditions are likely to modify the transmission of parasites and pathogens within reservoir species, and, as a consequence, alter the zoonotic risk for human. My thesis aims at elucidating the dynamics and mechanisms of the maintenance of ticks, tick-borne pathogens (TBPs) and the Puumala hantavirus (PUUV) in the reservoir host, the bank vole (Myodes glareolus, BV). In Northern Europe, tick-borne diseases are growing in importance to human because of the latitudinal expansion of the tick Ixodes ricinus. Field monitoring revealed that I. ricinus…

Overcoming resistance to HER2 blockade in breast cancer: AXL as a promising druggable target and prognostic biomarker

2022

Introduction: Breast cancer is a heterogeneous disease consisting of uncontrolled growth of epithelial cells originating in the ducts or breast lobules. It is currently the most diagnosed cancer worldwide and the fifth cause of cancer-related death in general population, but the first cause in women. Breast cancer incidence is higher in developed countries due to increased risk factors and to increased and earlier detection by mammography screening, which considerably reduces mortality. This is the reason why transitioning countries have higher mortality despite having lower incidence. Regarding the origin of the disease, it is evidenced that the pathways implicated in normal development of…

The Missing Member of the Partially O-Alkylated Resorcinarene Family: Synthesis and Conformation of Methyl Tetramethoxy Resorcinarene

2013

An improved Lewis acid catalyzed synthesis method for methyl tetramethoxy resorcinarene is described, which produced the missing lower rim methyl derivative of this partially O-alkylated resorcinarene family. Structural characterization by means of variable temperature NMR experiments and single crystal X-ray diffraction studies furthermore revealed that the resorcinarene core adopts different conformations in the solid state and in solution. peerReviewed

RSV disease in infants and young children: Can we see a brighter future?

2022

Respiratory syncytial virus (RSV) is a highly contagious seasonal virus and the leading cause of Lower Respiratory Tract Infections (LRTI), including pneumonia and bronchiolitis in children. RSV-related LRTI cause approximately 3 million hospitalizations and 120,000 deaths annually among children <5 years of age. The majority of the burden of RSV occurs in previously healthy infants. Only a monoclonal antibody (mAb) has been approved against RSV infections in a restricted group, leaving an urgent unmet need for a large number of children potentially benefiting from preventive measures. Approaches under development include maternal vaccines to protect newborns, extended half-life monoclon…

Early childhood growth is associated with lung function at 7 years: a prospective population-based study

2020

Previous studies have related early postnatal growth with later lung function but their interpretation is limited by the methods used to assess a child's growth. We aimed to assess the association of early childhood growth, measured by body mass index (BMI) trajectories up to 4 years, with lung function at 7 years.We included 1257 children from the Spanish Infancia y Medio Ambiente population-based birth cohort. Early childhood growth was classified into five categories based on BMI trajectories up to 4 years previously identified using latent class growth analysis. These trajectories differed in birth size ("lower", "average", "higher") and in BMI gain velocity ("slower", "accelerated"). W…