Search results for "ASES"

Editorial: Thymic Epithelial Cells: New Insights Into the Essential Driving Force of T-Cell Differentiation.

2021

Variants of human CLDN9 cause mild to profound hearing loss

2021

Hereditary deafness is clinically and genetically heterogeneous. We investigated deafness segregating as a recessive trait in two families. Audiological examinations revealed an asymmetric mild to profound hearing loss with childhood or adolescent onset. Exome sequencing of probands identified a homozygous c.475G>A;p.(Glu159Lys) variant of CLDN9 (NM_020982.4) in one family and a homozygous c.370_372dupATC;p.(Ile124dup) CLDN9 variant in an affected individual of a second family. Claudin 9 (CLDN9) is an integral membrane protein and constituent of epithelial bicellular tight junctions that form semi-permeable, paracellular barriers between inner ear perilymphatic and endolymphatic compartment…

The Synthesis of Quinoline‐based Tin Complexes with Pendant Schiff Bases

2019

Whilst pursuing the synthetic utility of quinoline‐based tin complexes, Me2Sn(Quin‐NO2)2 (1) and Ph2Sn(Quin‐NO2)2 (2) (Quin‐NO2 = 5‐nitroquinolino‐8‐oate) were synthesized bearing coordinatively inert nitro groups. Conventional reduction methodologies successfully converted 1 to Me2Sn(Quin‐NH2)2 (3) and 2 to Ph2Sn(Quin‐NH2)2 (4) (Quin‐NH2 = 5‐aminoquinolino‐8‐oate). The synthetically useful amine groups proved difficult to exploit in the presence of the central tin atom, however, a complete Schiff base functionalized Sn complex of the dimethyltin pro‐ligand Me2Sn(Quin‐py)2 (6) was successfully synthesized from 5‐[(pyridin‐2‐ylmethylene)amino]quinolin‐8‐ol (HQuin‐py; 5) in good yield via an …

Development of polypeptide-based therapeutics for topical delivery

2019

Topical administration represents the main route to attain local therapeutic activity of bioactive agents in several organs, such as the skin or the heart by means of devices that enhance drug transport through the endothelium acting as a reservoir. The complex structure of the skin protects the human body against potentially harmful external agents; however, this protective mechanism inhibits the penetration of topically administering bioactive agents employed for the treatment of skin diseases. Unfortunately, many of the topical drugs currently used or under evaluation in clinical trials lack the appropriate physico-chemical characteristics required for delivery through the skin. However,…

Single-cell analysis of population context advances RNAi screening at multiple levels

2012

Isogenic cells in culture show strong variability, which arises from dynamic adaptations to the microenvironment of individual cells. Here we study the influence of the cell population context, which determines a single cell's microenvironment, in image‐based RNAi screens. We developed a comprehensive computational approach that employs Bayesian and multivariate methods at the single‐cell level. We applied these methods to 45 RNA interference screens of various sizes, including 7 druggable genome and 2 genome‐wide screens, analysing 17 different mammalian virus infections and four related cell physiological processes. Analysing cell‐based screens at this depth reveals widespread RNAi‐induce…

Evaluación de signos tomográficos no exudativos en casos de degeneración macular asociada a la edad de tipo exudativo

2019

Objetivo: analizar la prevalencia de signos tomográficos no exudativos (onion sign, pseudoswelling, tubulación de la retina externa (ORT), pseudoquistes, subretinal clefts y atrofia macular) en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Material y métodos: 174 ojos de pacientes con DMAE neovascular que no habían recibido tratamiento previo fueron incluidos en el estudio. Se valoró la agudeza visual, el espesor central de la retina, la actividad de la neovascularización (NV) y la aparición o no de los distintos signos objeto de estudio en los tiempos 0 (visita inicial), 4 meses, 1 año, año y medio y a los 2 y 3 años de seguimiento. Se evaluaron también: la edad…

Burnout syndrome assessment among Spanish oral surgery consultants: A two populations comparative pilot study.

2021

Background The professional Burnout Syndrome (BOS) or Burnout is considered a professional disease made up of three interrelated dimensions (emotional exhaustion, depersonalization and lack of personal fulfillment). BOS has been documented to most severely affect the healthcare professions, especially dentists. On the other hand, its appearance has been documented at an early age, during dental training. However, there are no studies that analyze its incidence in professionals dedicated to Oral Surgery and Implantology, determining the age of onset and related factors. Material and Methods The modified Maslach questionnaire was carried out anonymously among the professors and students of th…

Efectos del Sorafenib, un inhibidor tirosina quinasa, en el control del tono vascular.

2018

El carcinoma hepatocelular o hepatocarcinoma (HCC) es uno de los tumores sólidos vasculares más conocidos, representa uno de los mayores problemas de salud en todo el mundo, siendo una de las enfermedades más comunes del hígado (70-85%) y una de las mayores causas de mortalidad relacionadas con el cáncer, siendo la tercera causa más común de muerte por cáncer Varias rutas carcinogénicas se han identificado en el desarrollo y progresión del HCC, proporcionando nuevas dianas moleculares para el tratamiento del HCC. Algunos fármacos que afectan a estas rutas incluyen, entre otros, el receptor del factor de crecimiento endotelial vascular (VEGFR). El sorafenib es un fármaco sistémico aprobado p…

The resonant state at filling factor {\nu} = 1/2 in chiral fermionic ladders

2017

Helical liquids have been experimentally detected in both nanowires and ultracold atomic chains as the result of strong spin-orbit interactions. In both cases the inner degrees of freedom can be considered as an additional space dimension, providing an interpretation of these systems as synthetic ladders, with artificial magnetic fluxes determined by the spin-orbit terms. In this work, we characterize the helical state which appears at filling $\nu=1/2$: this state is generated by a gap arising in the spin sector of the corresponding Luttinger liquid and it can be interpreted as the one-dimensional (1D) limit of a fractional quantum Hall state of bosonic pairs of fermions. We study its main…

Improving the Effect of Transcranial Alternating Current Stimulation (tACS): A Systematic Review

2021

With the development of electrical stimulation technology, traditional transcranial alternating current stimulation (tACS) technology has been found to have the drawback of not targeting a specific area accurately. Studies have shown that optimizing the number and position of electrodes during electrical stimulation has a very good effect on enhancing brain stimulation accuracy. At present, an increasing number of laboratories have begun to optimize tACS. However, there has been no study summarizing the optimization methods of tACS. Determining whether different optimization methods are effective and the optimization approach could provide information that could guide future tACS research. …