Search results for "ASIC"

showing 3 items of 11113 documents

Predominance of Type 1 Innate Lymphoid Cells in the Rectal Mucosa of Patients With Non-Celiac Wheat Sensitivity: Reversal After a Wheat-Free Diet.

2016

OBJECTIVES: Non-celiac wheat sensitivity (NCWS) is defined as a reaction to ingested wheat after exclusion of celiac disease and wheat allergy. As its pathogenesis is incompletely understood, we evaluated the inflammatory response in the rectal mucosa of patients with well-defined NCWS. METHODS: The prospective study included 22 patients with irritable bowel syndrome (IBS)-like clinical presentation, diagnosed with NCWS by double-blind placebo-controlled challenge. Eight IBS patients not improving on wheat-free diet were used as controls. Two weeks after oral challenge was performed with 80 grams of wheat daily, cells were isolated from rectal biopsies and thoroughly characterized by fluore…

wheat-free diet.0301 basic medicineNon-Celiac Wheat SensitivityPathologymedicine.medical_specialtyWheat free dietSettore MED/09 - Medicina Internabusiness.industryOriginal ContributionsInnate lymphoid cellGastroenterologyfood and beveragesType 1 Innate Lymphoid Cell03 medical and health sciences030104 developmental biology0302 clinical medicineRectal mucosaRectal MucosaImmunologyMedicine030211 gastroenterology & hepatologybusinessType 1 Innate Lymphoid Cells; Rectal Mucosa; Non-Celiac Wheat Sensitivity
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First report on the helminthfauna of the yellow-necked mouse, Apodemus flavicollis, in the Iberian Peninsula

2016

Summary Information about the prevalence of helminth parasites of the yellow-necked mouse, Apodemus flavicollis, in the Iberian Peninsula is almost non-existent and there is no reliable data reported from Spain. Fourteen A. flavicollis from the Erro River valley (Navarre, Spain) were examined for endoparasites, between February 2001 and July 2002. Thirteen specimens (92.9 %) of the total sample were parasitized by at least one of the following six helminth species: one trematode (Corrigia vitta), one cestode (Taenia parva larvae) and four nematodes (Trichuris muris, Calodium hepaticum, Heligmosomoides polygyrus and Syphacia stroma). This is the first report about the helminthfauna of A. fla…

yellow-necked mouse0301 basic medicineMedicine (General)TrichuriasisAgriculture (General)Ecology (disciplines)ZoologyBiologyS1-97203 medical and health sciencesR5-920Peninsulaparasitic diseasesmedicineHelminthsTaeniasisCestode infectionserro river valleygeographygeography.geographical_feature_categoryapodemus flavicollis030108 mycology & parasitologymedicine.diseasebiology.organism_classificationhumanitieshelminth communityiberian peninsulaCapillariasisApodemusAnimal Science and ZoologyParasitologyHelminthologia
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WDR45 Gene and Its Role in Pediatric Epilepsies

2021

AbstractWD repeat domain 45 (WDR45) gene has been increasingly found in patients with developmental delay (DD) and epilepsy. Previously, WDR45 de novo mutations were reported in sporadic adult and pediatric patients presenting iron accumulation, while heterozygous mutations were associated with β-propeller protein-associated neurodegeneration (BPAN), a subtype of neurodegeneration with brain iron accumulation disorders, characterized by extrapyramidal movement disorders and abnormal accumulation of iron in the basal ganglia. Overall, people harboring WDR45 mutations have moderate to severe DD and different types of seizures. The phenotype of adult patients is characterized by extrapyramidal…

β-propeller proteinassociated neurodegeneration0301 basic medicinemedicine.medical_specialtyEpilepsybusiness.industryIronWDR45Intellectual disabilitymedicine.disease03 medical and health sciencesEpilepsy030104 developmental biology0302 clinical medicineWDR45Pediatrics Perinatology and Child HealthIntellectual disabilitymedicineNeurology (clinical)PsychiatrybusinessGene030217 neurology & neurosurgeryJournal of Pediatric Neurology
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