Search results for "ASIS"
showing 10 items of 4190 documents
Transcriptomic identification of miR-205 target genes potentially involved in metastasis and survival of cutaneous malignant melanoma
2020
AbstractCutaneous melanoma is an aggressive neoplasm and is responsible for the majority of skin cancer deaths. Several miRNAs are involved in melanoma tumor progression. One of them is miR-205, the loss of which contributes to the development of melanoma metastasis. We evaluated whole-genome mRNA expression profiling associated with different miR-205 expression levels in melanoma cells. Differential expression analysis identified 243 differentially expressed transcripts including inositol polyphosphate 5′-phosphatase-like protein-1 (INPPL1) and BTB/POZ Domain-Containing Protein 3 (BTBD3). INPPL1 and BTBD3 were downregulated when melanoma cells expressed miR-205, indicating that these genes…
Nodular Lesion in Cheek With a Hair Tuft
2017
Trichostasis spinulosa is a rarely diagnosed disorder of the pilosebaceous unit, characterized by retention of telogen hairs within the dilated follicles. A hair tuft can be seen protruding from the follicles. We present a case of trichostasis spinulosa associated with intradermal melanocytic nevi, where dermoscopy helps to identify this entity.
The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα+ breast cancer cells
2013
In this study, we demonstrate that constitutive activation of Raf-1 oncogenic signaling induces stabilization and accumulation of Aurora-A mitotic kinase that ultimately drives the transition from an epithelial to a highly invasive mesenchymal phenotype in estrogen receptor α-positive (ERα(+)) breast cancer cells. The transition from an epithelial- to a mesenchymal-like phenotype was characterized by reduced expression of ERα, HER-2/Neu overexpression and loss of CD24 surface receptor (CD24(-/low)). Importantly, expression of key epithelial-to-mesenchymal transition (EMT) markers and upregulation of the stemness gene SOX2 was linked to acquisition of stem cell-like properties such as the ab…
Interactions related to non-host snails in the host-finding process of Euparyphium albuferensis and Echinostoma friedi (Trematoda: Echinostomatidae) …
2003
In order to determine whether the miracidia of Euparyphium albuferensis and Echinostoma friedi are sensitive to their host snail (HS) and capable of discriminating between HS and non-host snails (NHS), or whether these NHS can interfere and thus reduce the infection rates (decoy effect), a total of three experiments were conducted with HS, NHS and snail-conditioned water (SCW). Gyraulus chinensis is the HS for E. albuferensis miracidia, while Physa acuta, Radix peregra and Lymnaea fuscus are considered NHS. For E. friedi miracidia R. peregra, G. chinensis and L. fuscus are the HS, while P. acuta is the NHS. The NHS R. peregra produces the greatest decoy effect on Euparyphium albuferensis mi…
The ingreso mínimo vital and the right to social assistance of the european social charter
2021
En este artículo se analiza el Ingreso Mínimo Vital (IMV) desde la perspectiva de los derechos humanos y, en concreto, desde los estándares exigidos por el derecho a la asistencia social reconocido en la Carta Social Europea. El objetivo es valorar si el IMV cumple o no con las exigencias del derecho a la asistencia social tal y como ha sido reconocido en el artículo 13 de la Carta Social Europea, de acuerdo con la doctrina consolidada del Comité Europeo de Derechos Sociales del Consejo de Europa. El análisis de la regulación del IMV teniendo en cuenta las implicaciones de este derecho permite concluir que, a pesar de los importantes avances realizados, algunas mejoras son todavía necesaria…
Asistenta pakalpojumu nozīme sociālajā darbā ar cilvēkiem ar invaliditāti: Ogres pilsētā
2016
Maģistra darba tēma - “Asistenta pakalpojumu nozīme sociālajā darbā ar cilvēkiem ar invaliditāti: Ogres pilsētā”. Sociālā darbā pietrūkst novērtēšanas instrumenta, lai precīzi izvērtētu asistenta pakalpojuma apjomu, saturu, noteiktu klienta sociālas funkcionēšanas iespējas un to ierobežojumus. Par pētījuma mērķi izvēlēts izvērtēt asistenta pakalpojumu sociālajā darbā ar cilvēkiem ar invaliditāti Ogrē un piedāvāt novērtēšanas instrumentu asistenta pakalpojumiem. Darbā aplūkots, kādi asistenta pakalpojumu veidi ir pieejami Ogrē; kādi ir šķēršļi asistenta pakalpojumu saņemšanai un administrēšanai; kādi ir sasniegumi, saņemot un administrējot asistenta pakalpojumus, un sniegti ieteikumi, kā uzl…
Is ABA involved in tolerance responses to salinity by affecting cytoplasm ion homeostasis in rice cell lines?
2012
Abstract The ability of plant cells to maintain cytoplasm ion homeostasis under saline stress is among the main mechanisms involved in salt tolerance. To cope with excess Na + , cells extrude it from the cytoplasm, which requires expenditure of metabolic energy, provided by H + gradients generated by membrane-bound H + -pumps. ABA is well-known to be involved in physiological processes elicited or enhanced by stresses causing cell dehydration. In this work we studied the possible implication of this plant hormone in the control of salt-induced cellular mechanisms conducting to Na + extrusion from the cytoplasm. We used rice ( Oryza sativa L.) cell lines selected for their different toleranc…
BIBF 1120/ nintedanib : a new triple angiokinase inhibitor-directed therapy in patients with non-small cell lung cancer.
2013
Abstract: Introduction: Several new targeted agents with anti-angiogenic properties have been developed recently, including vandetanib, sunitinib, sorafenib, bevacizumab and others. Tumor development, progression, metastasis are strongly linked to angiogenesis. Targeted agents like bevacizumab, a monoclonal antibody which targets VEGF, have been fully developed in several solid tumors. These new agents strongly advocate that targeting angiogenesis is one of the best approaches for cancer therapy. Areas covered: Those agents that target additional pro-angiogenic intracellular signaling pathways beyond VEGF signaling have also the potential to contribute to anticancer therapies. The authors p…
Visceral fat area as a new independent predictive factor of survival in patients with metastatic renal cell carcinoma treated with antiangiogenic age…
2011
Abstract Purpose. A better identification of patients who are more likely to benefit from vascular endothelial growth factor–targeted therapy is warranted in metastatic renal cell carcinoma (mRCC). As adipose tissue releases angiogenic factors, we determined whether parameters such as visceral fat area (VFA) were associated with outcome in these patients. Experimental Design. In 113 patients with mRCC who received antiangiogenic agents (bevacizumab, sunitinib, or sorafenib) (n = 64) or cytokines (n = 49) as first-line treatment, we used computed tomography to measure VFA and subcutaneous fat area (SFA). We evaluated associations linking body mass index (BMI), SFA, and VFA to time to progres…
Implementation of the full explicitly correlated coupled-cluster singles and doubles model CCSD-F12 with optimally reduced auxiliary basis dependence.
2008
An implementation of the full explicitly correlated coupled-cluster singles and doubles model CCSD-F12 using a single Slater-type geminal has been obtained with the aid of automated term generation and evaluation techniques. In contrast to a previously reported computer code [T. Shiozaki et al., J. Chem. Phys. 129, 071101 (2008)], our implementation features a reduced dependence on the auxiliary basis set due to the use of a reformulated evaluation of the so-called Z-intermediate rather than straight forward insertion of an auxiliary basis expansion, which allows an unambiguous comparison to more approximate CCSD-F12 models. First benchmark results for total correlation energies and reactio…