Search results for "ASIS"
showing 10 items of 4190 documents
Discrete cortical representations and their stability in the presence of synaptic turnover
2015
Population imaging in mouse auditory cortex revealed clustering of neural responses to brief complex sounds: the activity of a local population typically falls close to one out of a small number of observed states [1]. These clusters appear to group sets of auditory stimuli into a discrete set of activity patterns and could thereby form the basis for representations of sound categories. However, to be useful for the brain, such representations should be robust against fluctuations in the underlying circuitry, which are significant even in the absences of any explicit learning paradigm [2]. Here we introduce a novel firing rate based circuit model of mouse auditory cortex to study the emerge…
Do patients with pathological health anxiety fear COVID-19? A time-course analysis of 12 single cases during the “first wave” of the COVID-19 pandemi…
2021
Objective Pre-existing health anxiety is associated with an intensified affective response to the novel COVID-19 pandemic in the general population. Still, results on the reaction of people with a diagnosis of pathological health anxiety (i.e., hypochondriasis) are scarce. Methods In the present study, we investigated the course of (health) anxiety related to SARS-CoV-2/COVID-19 in comparison to (health) anxiety related to other severe diseases (e.g., cancer) in a sample of 12 patients with the diagnosis of pathological health anxiety during the “first wave” of the COVID-19 pandemic in Germany. Both SARS-CoV-2 related anxiety and anxiety related to other severe diseases were assessed weekly…
Baltijos trynukai? Emigracija, migracija ir atsakas krizei
2021
Šiame straipsnyje nagrinėjama migracijos ir ekonominio vystymosi sankirta, kaip viena aktualiausių problemų, su kuriomis susiduria Baltijos šalys. Pasinaudojus empirine prieiga, lyginami vyriausybių veiksmai esant ekonominei 2008 metų krizei. Straipsnyje analizuojama, kaip jie išryškėjo socioekonominę dinamiką atskleidžiančioje statistikoje. Tyrime taikomi lyginamosios statistikos ir antrinių duomenų analizės metodai. Visos trys valstybės patiria panašių ateities iššūkių: visuomenės senėjimas ir gyventojų skaičiaus mažėjimas, tuo tarpu emigrantų sugrįžimas matomas kaip viena iš priemonių, galinčių padėti šias problemas spręsti. Estijoje vykstantys procesai leidžia manyti, kad jos Vyriausybe…
Comparison of non-Markovianity criteria in a qubit system under random external fields
2013
We give the map representing the evolution of a qubit under the action of non-dissipative random external fields. From this map we construct the corresponding master equation that in turn allows us to phenomenologically introduce population damping of the qubit system. We then compare, in this system, the time-regions when non-Markovianity is present on the basis of different criteria both for the non-dissipative and dissipative case. We show that the adopted criteria agree both in the non-dissipative case and in the presence of population damping.
Calculation of the conformational dependence of valence and Rydberg states in n-tetrasilane
1999
Abstract Previous CIS/6-31G ∗∗ and CASSCF/6-31G ∗ calculations of valence excited states of n -tetrasilane accounted qualitatively for the observed conformational dependence of condensed-phase UV absorption spectra. In an attempt to understand this result, we have performed CIS calculations with a larger basis set (MC-311G(2d) on Si, 6-311G on H, and 2s, 2p, and 2d diffuse orbitals at molecular center of mass). The first two excited states are of valence character at all dihedral angles if the molecule is isolated. When it is embedded in a rare gas cluster, the lowest four states are of valence character, and the results are nearly identical with those obtained without diffuse orbitals in t…
A novel rationale for targeting FXI: Insights from the hemostatic miRNA targetome for emerging anticoagulant strategies
2018
Abstract The treatment and prevention of thrombosis is currently under a period of rapid change with the replacement of traditional anticoagulant vitamin K antagonists, which impair the biosynthesis of a wide range of blood coagulation factors, with direct oral anticoagulants (DOACs), which specifically target factors FXa or FIIa. Nevertheless therapeutic targeting of blood coagulation is an inherently difficult task as it interferes with the delicate balance of pro- and anticoagulant activities. Although anticoagulants are employed in millions of thrombophilic patients worldwide each year, for a growing population with comorbidities who exhibit an increased risk of bleeding with DOAC treat…
Role of the aryl hydrocarbon receptor (AhR) signaling pathway in exceptional longevity in humans
2018
Centenarians are the best example of successfully aging in humans. Thus, the characterization of the biological processes and pathways in this population is an excellent strategy to understand the lifespan extension. The aryl hydrocarbon receptor (AhR) is a ligand-activated-transcription factor historically known for regulating expression of several important drug-detoxifying proteins. But recently its role in the immune response and in cellular homeostasis has been recognized. Furthermore, AhR is activated in C. Elegans in extreme longevity due to a dietary restriction. We report here results of a whole transcriptome analysis of centenarians. The main biological process was the immune resp…
The Respiratory Burst and Psoriasis
1988
Psoriasis is a disease affecting about 1–2% of the population worldwide, similar to diabetes mellitus.1 It occurs somewhat more frequently in the white population than among Asians and Eskimos.1 The disease has two peaks of onset, an early one occurring around the age of 20 and a later one around 60.2 In early-onset psoriasis, 85% of patients exhibit the HLA Cw6 antigen; in the late-onset group, no such pattern of inheritance can be found.2
Scalp psoriasis: report of efficient treatment with secukinumab
2018
Background: Psoriasis is a chronic inflammatory skin disease affecting 2-3% of the population in the world. The scalp is the most common, and frequently the first site of disease involvement. Occasionally it may be the only localization of psoriasis. Objective: Treatment of scalp psoriasis is often unsatisfactory, due to limited available topical therapy and reduced efficacy of some systemic drugs. Biologic therapies are recommended for severe psoriasis, resistant to topical treatment, but evidence from randomized, controlled studies is lacking regarding effectiveness on scalp-localized lesions. The aim of this paper is to show our experience on the efficacy of secukinumab on scalp psoriasi…
Kolmas merkitys toiseen : kinekfrasis suomalaisessa nykyrunoudessa
2016
In this article I develop the concept of kinekphrasis to designate a particular form of intermediality, speci cally, the verbal representation of cinema or other form of moving image. Kinekphrasis builds upon ekphrasis, the classical rhetorical term that today generally refers to texts about static artworks, such as paintings and statues. Representing the medial complex of cinema, however, sets a distinct sensorial and semiotic challenge to a text and brings about a form of intermediality di erent from the traditional ekphrasis. I exemplify kinekphrasis with a reading of contemporary Finnish poetry, namely, individual poems by Pauliina Haasjoki and V. S. Luoma-aho, and one book-length work,…