Search results for "ASIS"

The Role of GSK-3 in Cancer Immunotherapy: GSK-3 Inhibitors as a New Frontier in Cancer Treatment

2020

The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified because of its key role in the regulation of glycogen synthesis. However, it is now well-established that GSK-3 performs critical functions in many cellular processes, such as apoptosis, tumor growth, cell invasion, and metastasis. Aberrant GSK-3 activity has been associated with many human diseases, including cancer, highlighting its potential therapeutic relevance as a target for anticancer therapy. Recently, newly emerging data have demonstrated the pivotal role of GSK-3 in the anticancer immune response. In the last few years, many GSK-3 inhibitors have been developed, and some are currently being te…

CD40 activity on mesenchymal cells negatively regulates OX40L to maintain bone marrow immune homeostasis under stress conditions

2021

BackgroundWithin the bone marrow (BM), mature T cells are maintained under homeostatic conditions to facilitate proper hematopoietic development. This homeostasis depends upon a peculiar elevated frequency of regulatory T cells (Tregs) and immune regulatory activities from BM-mesenchymal stem cells (BM-MSCs). In response to BM transplantation (BMT), the conditioning regimen exposes the BM to a dramatic induction of inflammatory cytokines and causes an unbalanced T-effector (Teff) and Treg ratio. This imbalance negatively impacts hematopoiesis, particularly in regard to B-cell lymphopoiesis that requires an intact cross-talk between BM-MSCs and Tregs. The mechanisms underlying the ability of…

Bakteryjne strategie wykorzystania jonów metali – kulisy chemii koordynacyjnej

2022

n the Biological Inorganic Chemistry Group we are inspired to better understand metal ions acquisition and homeostasis in pathogenic bacteria, and in this review we present three different approaches to the role of these processes. The growing importance of a full understanding of the iron transport system in pathogens prompted us to study synthetic analogs of siderophores, used as structural probes in the process of iron uptake by microorganisms. The ferrichrome biomimetic analogs allowed efficient Fe(III) chelation under biological conditions and were recognized better by P. putida. than E. coli, suggesting differences in uptake mechanisms. Addition of a fluorescent probe to the compound …

The oral melanoma: atypical immunophenotype in the metastatic area.Melanoma Res. 2008 Feb;18(1):70-2.

2008

Estudio del papel de la EMT y las vías de control inmunológico en las micrometástasis moleculares detectadas en ganglio centinela de pacientes con ca…

2021

En los últimos años se ha incrementado el uso de técnicas de biología molecular para mejorar el diagnóstico y conocer mejor la etiología del CP (cáncer pulmonar), debido a que la posibilidad de padecerlo ha sido definida como la interrelación entre la exposición a carcinógenos ambientales y la susceptibilidad individual determinada genéticamente (D’Amico et al., 1999). Dicha susceptibilidad genética es la que resulta determinante para entender por qué, siendo el tabaco responsable de más del 90% de los CP en el hombre y del 80% en la mujer, sólo un 11-12% de los fumadores desarrollan un cáncer (Kratz et al., 2012). Sin embargo, comprender qué factores genéticos determinan una mayor propensi…

Tertiary lymphoid structures in pulmonary metastases of microsatellite stable colorectal cancer

2023

Tertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates located at sites of chronic inflammation and recognized as prognosticators in several cancers. We aimed to analyse the prognostic effect of TLSs in colorectal cancer (CRC) pulmonary metastases and primary tumours, with a comparison to the CD3+ and CD8+ cell density-based immune cell score (ICS). For TLS density and TLS maximum diameter analysis, 67 pulmonary metastases and 63 primary tumours were stained with haematoxylin and eosin. For ICS scoring and analysis, CD3 and CD8 immunohistochemistry was performed. Excellent interobserver agreement was achieved in all TLS measurements. Of all patients, 36 patients had low TLS den…

Impact of physical effort on von Willebrand factor’s activity and concentration in blood

2020

Background and Study Aim: Physical exercise causes a wide range of physiological changes including the production and release of haemostasis regulating factors. One of these factors is von Willebrand factor (vWf)- a glycoprotein responsible for both platelet adhesion and coagulation cascade. Material and Methods: The impact of physical effort on von Willebrand’s factor’s concentration (vWf:Ag) and activity (vWf:CBA) underwent analysis in the group of 42 people (22 men and 20 women) aged 19-22 (mean 20, SD 8 months). Physical effort was induced by 35 minutes of swimming in indoor swimming pool. Results: Physical exercise in form of swimming causes an increase of Willebrand’s factor’s concent…

Ustekinumab therapy changes the transcriptional activity pattern of TGF-β1–3 genes

2019

Introduction One of the examples of genes whose expression can be altered by the action of ustekinumab is TGF-β. It is a pleiotropic cytokine whose activity affects psoriatic changes and the state of homeostasis of the whole organism. Aim To evaluate the effect of ustekinumab on the transcriptional activity of TGF-b family genes in patients with psoriatic arthritis and to check whether the results obtained can be helpful in monitoring the progress of treatment. Material and methods From total PBMCs obtained from peripheral blood of 14 patients with psoriatic arthritis, total RNA was isolated. The expression level of the TGF-β1, TGF-β2 and TGF-β3 genes was determined by RT-qPCR in real time.…

Rasismin vastainen politiikka Suomessa : perusteluja ja käytäntöjä

2001

Finnishness, Whiteness and Coloniality: An Introduction

2022

Peer reviewed