Search results for "ASIS"

Intervención farmacéutica sobre la prescripción inapropiada del paciente mayor polimedicado en diferentes niveles asistenciales

2017

A medida que aumenta la esperanza de vida de la población, las personas viven más tiempo con discapacidad y múltiples morbilidades. Esta situación tiene importante repercusión en los sistemas de salud a nivel mundial por su relación directa con el incremento de la cronicidad, pluripatología y polimedicación. Está demostrado que a mayor número de fármacos prescritos, aunque éstos fuesen apropiados, mayor es la posibilidad de que haya alguno no necesario y de que aparezcan efectos adversos prevenibles. La polimedicación es apropiada, cuando el paciente toma muchos fármacos, pero todos ellos tienen indicación clínica. Y polimedicación es inapropiada, cuando se toman más medicamentos de los clí…

The existence of solutions for the modified (p(x), q(x))-Kirchhoff equation

2022

We consider the Dirichlet problem-Delta(Kp)(p(x))u(x) - Delta(Kq)(q(x))u(x) = f(x, u(x), del u(x)) in Omega, u vertical bar(partial derivative Omega) = 0,driven by the sum of a p(x)-Laplacian operator and of a q(x)-Laplacian operator, both of them weighted by indefinite (sign-changing) Kirchhoff type terms. We establish the existence of weak solution and strong generalized solution, using topological tools (properties of Galerkin basis and of Nemitsky map). In the particular case of a positive Kirchhoff term, we obtain the existence of weak solution (= strong generalized solution), using the properties of pseudomonotone operators.

Psichoemotional and ergonomic work environment risk factors relation to pharmacists and assistant pharmacists work ability

2016

„Psihosociālo un ergonomisko darba vides risku saistība ar farmaceitu un farmaceita asistentu darbspējām”. Darba autore: Līga Šulce. Darba zinātniskā vadītāja: asoc. prof., Dr. med. Ženija Roja. Darbs izklāstīts uz 88 lpp., ietver 46 attēlus, 4 tabulas, 7 pielikumus, 63 informatīvos avotus. Maģistra darbs sastāv no 4 daļām. Pirmajā daļā ir apkopota un analizēta literatūra par farmaceitu un farmaceita asistentu profesiju, kā arī ergonomiskiem un psihosociāliem riskiem, un darbspējām. Literatūras analīze liecina, ka farmaceiti un farmaceita asistenti savā ikdienas darbā saskaras ar psihosociāliem un ergonomiskiem riskiem. Otrajā daļā ir aprakstītas pētījumā lietotās metodes, bet trešajā daļā …

The prevalence of the obesity in patients with moderate to severe psoriasis in Sicily populations

2009

Postpartum pubic symphysis diastasis: A case report and review of literature

2014

Correspondence between generalized binomial field states and coherent atomic states

2008

We show that the N-photon generalized binomial states of electromagnetic field may be put in a bijective mapping with the coherent atomic states of N two-level atoms. We exploit this correspondence to simply obtain both known and new properties of the N-photon generalized binomial states. In particular, an over-complete basis of these binomial states and an orthonormal basis are obtained. Finally, the squeezing properties of generalized binomial state are analyzed.

Lectures on quasiconformal and quasisymmetric mappings

2009

Jeu de Taquin and Diamond Cone for so(2n+1, C)

2020

International audience; The diamond cone is a combinatorial description for a basis of a natural indecomposable n-module, where n is the nilpotent factor of a complex semisimple Lie algebra g. After N. J. Wildberger who introduced this notion, this description was achieved for g = sl(n) , the rank 2 semisimple Lie algebras and g = sp (2n).In this work, we generalize these constructions to the Lie algebra g = so(2n + 1). The orthogonal semistandard Young tableaux were defined by M. Kashiwara and T. Nakashima, they index a basis for the shape algebra of so(2n + 1). Defining the notion of orthogonal quasistandard Young tableaux, we prove that these tableaux describe a basis for a quotient of t…

Rac1-Regulated Endothelial Radiation Response Stimulates Extravasation and Metastasis That Can Be Blocked by HMG-CoA Reductase Inhibitors

2011

Radiotherapy (RT) plays a key role in cancer treatment. Although the benefit of ionizing radiation (IR) is well established, some findings raise the possibility that irradiation of the primary tumor not only triggers a killing response but also increases the metastatic potential of surviving tumor cells. Here we addressed the question of whether irradiation of normal cells outside of the primary tumor augments metastasis by stimulating the extravasation of circulating tumor cells. We show that IR exposure of human endothelial cells (EC), tumor cells (TC) or both increases TC-EC adhesion in vitro. IR-stimulated TC-EC adhesion was blocked by the HMG-CoA reductase inhibitor lovastatin. Glycyrr…

Aplidin® induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 ph…

2006

Aplidin® is an antitumor agent in phase II clinical trials that induces apoptosis through the sustained activation of Jun N-terminal kinase (JNK). We report that Aplidin® alters glutathione homeostasis increasing the ratio of oxidized to reduced forms (GSSG/GSH). Aplidin® generates reactive oxygen species and disrupts the mitochondrial membrane potential. Exogenous GSH inhibits these effects and also JNK activation and cell death. We found two mechanisms by which Aplidin® activates JNK: rapid activation of Rac1 small GTPase and downregulation of MKP-1 phosphatase. Rac1 activation was diminished by GSH and enhanced by L-buthionine (SR)-sulfoximine, which inhibits GSH synthesis. Downregulatio…