Search results for "ASTER"
showing 10 items of 2223 documents
Traditionally used Thai medicinal plants: in vitro anti-inflammatory, anticancer and antioxidant activities.
2009
In order to assess traditional Thai claims about the therapeutic potential of medicinal plants and to select plants for future phytochemical research, nine plant species with anti-inflammatory uses were selected from Thai textbooks and assessed for their in vitro anti-inflammatory, antiproliferative and antioxidant activities.Nuclear factor-kappaB (NF-kappaB) inhibitory effects in stably transfected HeLa cells were determined by luciferase assay, and effects on LPS-induced pro-inflammatory mediators prostaglandin E2 (PGE2), interleukin (IL)-6, IL-1beta, and tumour necrosis factor (TNF)alpha in primary monocytes were assessed by ELISA. Cytotoxic activities were examined against HeLa cells, h…
Novel σ1 antagonists designed for tumor therapy: Structure – activity relationships of aminoethyl substituted cyclohexanes
2021
Abstract Depending on the substitution pattern and stereochemistry, 1,3-dioxanes 1 with an aminoethyl moiety in 4-position represent potent σ1 receptor antagonists. In order to increase the stability, a cyclohexane ring first replaced the acetalic 1, 3-dioxane ring of 1. A large set of aminoethyl substituted cyclohexane derivatives was prepared in a six-step synthesis. All enantiomers and diastereomers were separated by chiral HPLC at the stage of the primary alcohol 7, and their absolute configuration was determined by CD spectroscopy. Neither the relative nor the absolute configuration had a large impact on the σ1 affinity. The highest σ1 affinity was found for cis-configured benzylamines…
Towards understanding the abundance of non-pollen palynomorphs : A comparison of fossil algae, algal pigments and sedaDNA from temperate lake sedimen…
2018
Given the increased interest in non-pollen palynomorphs (microscopic objects other than pollen identified from pollen slides) in palaeoecological studies, it is necessary to seek a deeper understanding of the reliability of these results. We combined quantitative information of algal pigments and sedimentary ancient DNA (sedaDNA) of phylotaxonomical resolution to validate the richness and abundance of fossil algae in the sediment of a small temperate lake. For the first time, fossil and sedaDNA algae data were combined in a composite data-set and used to reconstruct algae turnover rates over the last 14,500 years. This comparison serves as both an example of howfossil algae can be used to a…
Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms.
2019
Mitochondria have been increasingly recognized as a central regulatory nexus for multiple metabolic pathways, in addition to ATP production via oxidative phosphorylation (OXPHOS). Here we show that inducing mitochondrial DNA (mtDNA) stress in Drosophila using a mitochondrially-targeted Type I restriction endonuclease (mtEcoBI) results in unexpected metabolic reprogramming in adult flies, distinct from effects on OXPHOS. Carbohydrate utilization was repressed, with catabolism shifted towards lipid oxidation, accompanied by elevated serine synthesis. Cleavage and translocation, the two modes of mtEcoBI action, repressed carbohydrate rmetabolism via two different mechanisms. DNA cleavage activ…
Ģenētisko algoritmu papildināšana ceļojošā tirgoņa problēmas risināšanai
2016
Bakalaura darbā tiek risināta ceļojošā tirgoņa problēma, kurā ir jāatrod īsākais ceļš starp visām dotajām pilsētām, apmeklējot katru vienreiz un atgriežoties sākuma pilsētā. Darba mērķis ir papildināt ģenētiskos algoritmus, lai uzlabotu to spēju risināt ceļojošā tirgoņa problēmu. Darba uzdevumi ir izpētīt ģenētisko algoritmu papildināšanas iespējas, izveidot pamata risinājumu, veikt tā papildināšanu un novērtēt tā rezultativitāti izvirzītās problēmas risināšanā. Darba rezultātā tika izstrādāta struktūra, kas papildina ģenētiskos algoritmus ar Kohonen klasterizāciju, tuvākā kaimiņa algoritmu, 2-opt optimizāciju un stohastisko kalnā kāpšanu, kā arī tika iegūts izstrādāto papildinājumu novērtē…
Kvantu mašīnmācīšanās – klasterēšanas algoritma implementēšana
2020
Klasterēšana ir populārākā bez uzraudzības mašīnmācīšanās metode, kuras pamatprincips ir noteikt datu punktu sadalījumu apakšgrupās vai kopās, lai vienā un tā pašā klastera novērojumiem būtu zināma līdzība. Kvantu mašīnmācīšanās šobrīd ir aktuālā tēma, un kvantu algoritmi tiek izmantoti lai paātrinātu un/vai izlabotu klasiskus algoritmus. Darba ietvaros tiek analizēts un implementēts kvantu mašīnmācīšanās algoritms klasterēšanai, tas tiek salīdzināts ar klasisko algoritma implementāciju. Algoritms tiek implementēts, izmantojot Python programmēšanas valodu un Qiskit bibliotēku kvantu skaitļošanai, kas ļauj kvantu skaitļošanas kodu laist gan uz simulatoriem, gan uz IBM kvantu ierīcēm, kas ir …
Requirements for Relief Distribution Decision-Making in Humanitarian Logistics
2020
Making efficient and effective decisions in the chaotic environment of humanitarian relief distribution (HRD) is challenging. Decision-makers need to concentrate on numerous decision factors categorized into decision objectives, variables, and constraints. Recent HRD literature focuses on optimizing procedures while neglecting the quantification of essential requirements (decision factors) for information systems to provide decision-making support. In this article, we address this gap by accumulating affecting decision factors from both literature and practice. We investigated the practical implications of these factors in HRD decision-making by measuring the preferences of a Delphi panel c…
Introduction to the communication and information systems technology for emergency management minitrack
2013
The world spends annually between 16 and 23 billion US dollars in disaster assistance. In 2010 an estimated 373 natural disasters occurred, causing 296, 800 victims and affecting more than 207 million people. By 2050 the number of people living in areas especially prone to natural disasters will probably double (from 680 to 1500 million). Communication and Information System Technology is profoundly changing the management of disasters and emergencies. Mobile devices and social media are being used by citizens in innovative ways to help them manage the consequences of disasters for themselves, families, and communities. The trend of increasing traffic flow originating from affected citizens…
The master’s dissertation viva by video conference: strategies and best practices
2019
Durante la última década, se han publicado numerosos estudios sobre el proceso de elaboración y evaluación de los trabajos de fin de máster (TFM) (Da Cunha, 2016; García & Martínez-Clares, 2012; González-Calero & Turégano, 2011), sobre las fases de tutorización y acompañamiento al estudiante (Flores, Martínez, Martínez López, Pascual, & Sanz, 2013) y sobre las competencias a adquirir tras su finalización (Cabrera, Sangrà & Rodera, 2012; Serrano & Pontes, 2015; Viejo & Ortega Ruiz, 2018). Sin embargo, no resultan tan evidentes las investigaciones que analizan la fase de preparación y defensa pública de estos trabajos, siendo, sin embargo, la que genera más incomodidad entre el estudiantado. …
Disaster vulnerability by demographics?
2020
This article provides a brief overview of the relationship between disaster vulnerability and demographic variables. Population numbers and densities are examined along with using a gender focus as illustrative of individual characteristics. For the most part, people’s and society’s choices create vulnerabilities based on demographics rather than specific demographic characteristics inevitably conferring vulnerability.