Search results for "ATAL"
showing 10 items of 10591 documents
The E3 Ubiquitin Ligase MID1 Catalyzes Ubiquitination and Cleavage of Fu
2014
Sonic Hedgehog (SHH)-GLI signalling plays an important role during embryogenesis and in tumorigenesis. The survival and growth of several types of cancer depend on autonomously activated SHH-GLI signalling. A protein complex containing the ubiquitin-ligase MID1 and protein phosphatase 2A (PP2A) regulates the nuclear localization and transcriptional activity of GLI3, a transcriptional effector molecule of SHH, in cancer cell lines with autonomously activated SHH signalling. However, the exact molecular mechanisms that mediate the interaction between MID1 and GLI3 remained unknown. Here, we show that MID1 catalyses the ubiquitination and proteasomal cleavage of the GLI3-regulator Fu. Our data…
El títol com a clàusula del contracte metaficcional irònic en la narrativa contemporània
2011
El treball analitza de quina manera els títols poden convertir-se en potents recursos al servei del discurs metaficcional a través d'un corpus d'estudi centrat en un conjunt de contes, narracions i reculls de contes de la literatura catalana del segle XX. Els procediments que generen, des del títol de l'obra, la consciència metaficcional són: el qüestionament del gènere al qual cal adscriure el text; posar en evidència les dinàmiques que governen la relació entre fragment i totalitat; cridar l'atenció sobre les característiques tècniques o materials del text; i inserir el text dins d'un debat literari extern que en determina la interpretació.
Fecal Metagenomics and Metabolomics Identifying Microbial Signatures in Non-Alcoholic Fatty Liver Disease
2023
The frequency of non-alcoholic fatty liver disease (NAFLD) has intensified, creating diagnostic challenges and increasing the need for reliable non-invasive diagnostic tools. Due to the importance of the gut–liver axis in the progression of NAFLD, studies attempt to reveal microbial signatures in NAFLD, evaluate them as diagnostic biomarkers, and to predict disease progression. The gut microbiome affects human physiology by processing the ingested food into bioactive metabolites. These molecules can penetrate the portal vein and the liver to promote or prevent hepatic fat accumulation. Here, the findings of human fecal metagenomic and metabolomic studies relating to NAFLD are reviewed. The …
Cross-Linked Thiazolidine Network as Support for Palladium: A New Catalyst for Suzuki and Heck Reactions
2015
A thiazolidine-based material was used for the first time as support for palladium. The support was prepared by starting from a highly cross-linked thiazolium-based material, obtained by radical oligomerization of a bisvinylthiazolium dibromide salt in the presence of 3-mercaptopropyl-modified silica SBA-15. Palladium was immobilized by treatment with tetrachloropalladate salt. Reduction with sodium borohydride afforded a thiazolidine-based material that acted as ligands for the Pd species. The thiazolidine-based palladium catalyst was fully characterized and, working in only 0.1 mol% amount, displayed good activity in the Suzuki-Miyaura and in the Heck reactions. Several biphenyl and alken…
Decomposition Process of Carboxylate MOF HKUST-1 Unveiled at the Atomic Scale Level
2016
HKUST-1 is a metal-organic framework (MOF) which plays a significant role both in applicative and basic fields of research, thanks to its outstanding properties of adsorption and catalysis but also because it is a reference material for the study of many general properties of MOFs. Its metallic group comprises a pair of Cu2+ ions chelated by four carboxylate bridges, forming a structure known as paddle-wheel unit, which is the heart of the material. However, previous studies have well established that the paddle-wheel is incline to hydrolysis. In fact, the prolonged exposure of the material to moisture promotes the hydrolysis of Cu-O bonds in the paddle-wheels, so breaking the crystalline n…
Scanning Tunneling Spectroscope Use in Electrocatalysis Testing
2010
Published version of an article from the journal: Materials (1996-1944). Also available from publisher: http://dx.doi.org/10.3390/ma3063675 The relationship between the electrocatalytic properties of an electrode and its ability to transfer electrons between the electrode and a metallic tip in a scanning tunneling microscope (STM) is investigated. The alkaline oxygen evolution reaction (OER) was used as a test reaction with four different metallic glasses, Ni78Si8B14, Ni70Mo20Si5B5, Ni58Co20Si10B12, and Ni25Co50Si15B10, as electrodes. The electrocatalytic properties of the electrodes were determined. The electrode surfaces were then investigated with an STM. A clear relationship between the…
Exposure to metals and metalloids among pregnant women from Spain: Levels and associated factors
2021
This study was funded by Grants from EU (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1); Spain: ISCIII (Red INMA G03/176, CB06/02/0041; FIS-FEDER: PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/0867, PI06/1213, PI07/0314, PI09/00090, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/2032, PI13/02187, PI14/00891, PI14/01687, PI16/1288, PI17/00663, PI18/01142 and PI19/1338; Miguel Servet FEDER MS15/00025, MS20/0006, CPII16/00051, and FIS-FSE: 17/00260); CIBERESP; Generalitat Valenciana: FISABIO (UGP 15-230, UGP-15-244, and UGP-15-249), AICO/2020/285, and Alicia Koplowitz Foundation 2017; Generalitat de Catalunya-CIRIT 1999SGR 00241; Department of Health…
Cobalt, copper and zinc octacarboxyphthalocyanine activity in anaerobic oxidation of -SH group containing compounds
2007
Wykonano serię pomiarów elektrochemicznych w celu określenia aktywności katalitycznej oktakarboksyftalocyjaniny kobaltu, cynku i miedzi w anaerobowym utlenianiu związków organicznych zawierających grupę-SH. Badano następujące substraty: 2-tioetanol (TE), L-cysteinę i 1,4-ditio-2,3-butanodiol (DTT). Jako elektrodę wskaźnikową stosowano elektrodę grafitową GE. Przeprowadzono badania dla roztworów substratów, w których potencjalny katalizator był rozpuszczony, jak i dla roztworów, w których katalizator był zaadsorbowany na powierzchni elektrody GE. Jedynie oktakarboksyftalocyjanina kobaltu, CoPcOC, zaadsorbowana na powierzchni elektrody grafitowej okazała się dobrym katalizatorem heterogennym.…
Psychobiological effects of perinatal exposure to odorants in mice. Part I: Morphological changes in the olfactory epithelium
2010
International audience
Postnatal predator exposure reduces fear and anxiety behaviors in adult mice
2010
Poster; Predator cues are very efficient to induce fear in rodents but most studies use adult subjects and not pups. Nevertheless, a perinatal stress can have a significant effect on behavior and on physiology at adulthood. An early stress (foot shock, restraint, mother separation) is able to modulate behaviors later and the aim of this study was to examine if the synthetic predator odor 2,3,5-trimethylthiazoline (TMT) presented to neonates modifies fear and anxiety-related behaviors in adult female mice.