Search results for "ATAL"
showing 10 items of 10591 documents
Mobility of Cultures and Knowledge Management in Contemporary Europe
2012
In the aftermath of the fall of the Iron Curtain, the European Union (EU) has included more and more new member states from Central and Eastern parts of the European continent. This enlargement process has increased the cultural diversity of the European community as new languages and minority groups have been subsumed into the EU. It is the purpose of this article to discuss the challenges that result from the EU's enlargement, together with the added intra-European mobility of cultures, that affect the national knowledge infrastructures. Based on recent social scientific scholarship on mobility and cultures, this article proposes that knowledge management in contemporary Europe is not onl…
Sueños y violencias, migrantes latinoamericanas en su paso por México
2019
Conformational Dynamics of the Dengue Virus Protease Revealed by Fluorescence Correlation and Single-Molecule FRET Studies.
2021
The dengue virus protease (DENV-PR) represents an attractive target for counteracting DENV infections. It is generally assumed that DENV-PR can exist in an open and a closed conformation and that active site directed ligands stabilize the closed state. While crystal structures of both the open and the closed conformation were successfully resolved, information about the prevalence of these conformations in solution remains elusive. Herein, we address the question of whether there is an equilibrium between different conformations in solution which can be influenced by addition of a competitive inhibitor. To this end, DENV-PR was statistically labeled by two dye molecules constituting a FRET …
PTC124-mediated translational readthrough of a nonsense mutation causing Usher syndrome type 1C.
2011
We investigated the therapeutic potential of the premature termination codon (PTC) readthrough-inducing drug PTC124 in treating the retinal phenotype of Usher syndrome, caused by a nonsense mutation in the USH1C gene. Applications in cell culture, organotypic retina cultures, and mice in vivo revealed significant readthrough and the recovery of protein function. In comparison with other readthrough drugs, namely the clinically approved readthrough-inducing aminoglycoside gentamicin, PTC124 exhibits significant better retinal biocompatibility. Its high readthrough efficiency in combination with excellent biocompatibility makes PTC124 a promising therapeutic agent for PTCs in USH1C, as well a…
STAT1 and Its Crucial Role in the Control of Viral Infections
2022
The signal transducer and activator of transcription (STAT) 1 protein plays a key role in the immune response against viruses and other pathogens by transducing, in the nucleus, the signal from type I, type II and type III IFNs. STAT1 activates the transcription of hundreds of genes, some of which have been well characterized for their antiviral properties. STAT1 gene deletion in mice and complete STAT1 deficiency in humans both cause rapid death from severe infections. STAT1 plays a key role in the immunoglobulin class-switch recombination through the upregulation of T-bet; it also plays a key role in the production of T-bet+ memory B cells that contribute to tissue-resident humoral memory…
Dating archaeological copper/bronze artifacts by using the voltammetry of microparticles.
2014
A method for dating copper/bronze archaeological objects aged in atmospheric environments is proposed based on the specific signals for cuprite and tenorite corrosion products measured through the voltammtry of microparticles method. The tenorite/cuprite ratio increased with the corrosion time and fitted to a potential law that yielded a calibration curve usable for dating purposes.
Modellazione numerica del comportamento meccanico delle volte catalane
2010
Il presente lavoro riguarda la modellazione numerica del comportamento costitutivo delle cosiddette volte in foglio (le bóvedas tabicadas) che rappresentano una delle tecniche edilizie tradizionali catalane più diffusamente impiegate da alcuni tra i più grandi architetti spagnoli (primo fra tutti Gaudí) alla fine del XIX secolo [1-3]. Tali volte risultano fondamentalmente costituite da strati alternati di spessore in generale pressoché uguale di mattoni e di malta. Questa particolare caratteristica viene studiata in questo lavoro nel quale si vuole confrontare la modellazione del comportamento costitutivo considerando il materiale come ideale omogeneo con quella ottenuta modellando il mater…
Analisi numerica e sperimentale sul comportamento meccanico delle volte catalane
2008
Cybersecurity Attacks on Software Logic and Error Handling Within ADS-B Implementations: Systematic Testing of Resilience and Countermeasures
2022
Automatic Dependent Surveillance-Broadcast (ADS-B) is a cornerstone of the next-generation digital sky and is now mandated in several countries. However, there have been many reports of serious security vulnerabilities in the ADS-B architecture. In this paper, we demonstrate and evaluate the impact of multiple cyberattacks on ADS-B via remote radio frequency links that affected various network, processing, and display subsystems used within the ADS-B ecosystem. Overall we implemented and tested 12 cyberattacks on ADS-B in a controlled environment, out of which 5 attacks were presented or implemented for the first time. For all these attacks, we developed a unique testbed that consisted of 1…
Water in stereoselective organocatalytic reactions
2009
In this review, recent advances in asymmetric organocatalytic reactions carried out with variable amounts of water, from substoichiometric to a large excess (reaction medium), are discussed. We also summarize several proposed mechanisms for the different possibilities of the action of water both in the increased activity of the catalyst and in the asymmetric induction. Finally, the application of this catalytic methodology to the enantioselective synthesis of valuable compounds through enamine or iminium catalysis is presented.