Search results for "ATAL"
showing 10 items of 10591 documents
Ensayo clínico multicéntrico, aleatorizado y enmascarado con topiramato versus placebo para el tratamiento de recién nacidos con encefalopatía hipóxi…
2021
Antecedentes: La encefalopatía hipóxico-isquémica (EHI) perinatal constituye una de de las principales causas de muerte o discapacidad a largo plazo en recién nacidos a término en el mundo occidental, afectando a aproximadamente 1-4 por cada 1000 nacidos vivos y, en consecuencia, a alrededor de 5000-20000 recién nacidos por año en Europa. La hipotermia terapéutica se ha convertido en el tratamiento estándar de la EHI moderada o grave, siendo una terapia segura y eficaz para mejorar el desarrollo neurológico tras un insulto hipóxico-isquémico perinatal. A pesar de la hipotermia y las mejoras en los cuidados intensivos neonatales, el 45-50% de los recién nacidos con EHI moderada o grave muere…
La gramaticalització del futur i el condicional en català antic: el cas de les Vides de sants rosselloneses i els Furs de València
2021
El futur i el condicional de les llengües romàniques sorgeixen de la perífrasi llatina CANTĀRE HABEŌ mitjançant un procés de gramaticalització que passa per diferents estadis. En la llengua medieval, conviuen les formes sintètiques (el faré, faré-lo) i les formes analítiques (fer-lo he), que es distribueixen segons els diferents entorns sintàctics seguint la sintaxi medieval dels pronoms febles. En aquest estudi de corpus, s’extrauen mitjançant el CICA les dades de dues obres del segle XIII, un text religiós, les Vides de sants rosselloneses, i un text jurídic, els Furs de València, per tal de conèixer la sintaxi dels clítics medievals i d’observar el grau de gramaticalització que mostren l…
The Epigenetics of the Endocannabinoid System
2020
The endocannabinoid system (ES) is a cell-signalling system widely distributed in biological tissues that includes endogenous ligands, receptors, and biosynthetic and hydrolysing machineries. The impairment of the ES has been associated to several pathological conditions like behavioural, neurological, or metabolic disorders and infertility, suggesting that the modulation of this system may be critical for the maintenance of health status and disease treatment. Lifestyle and environmental factors can exert long-term effects on gene expression without any change in the nucleotide sequence of DNA, affecting health maintenance and influencing both disease load and resistance. This potentially …
Identification and characterization of autoantibodies against catalase and α-enolase in patients with primary sclerosing cholangitis
1998
SUMMARY Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown aetiology. Recent studies have shown that genetic factors and both cellular and humoral immunological abnormalities are important in the pathogenesis of PSC. The most prominent autoantibodies in PSC are anti-neutrophil cytoplasmic antibodies (ANCA). The autoepitopes of ANCA in PSC are not well defined. The aim of this study was to identify corresponding ANCA autoantigens in patients with PSC. A biochemical approach with enrichment and partial purification of soluble neutrophil proteins, detection of autoantibodies by Western blot and partial amino acid sequencing were used. Two new autoantigen/aut…
Molecular Approaches Fighting Nonsense
2021
Nonsense mutations are the result of single nucleotide substitutions in the DNA that change a sense codon (coding for an amino acid) to a nonsense or premature termination codon (PTC) within the coding region of the mRNA [...]
Electrocatalysis of neurotransmitter catecholamines by 2,4,6-triphenylpyrylium ion immobilized inside zeolite Y supercages
1999
2,4,6-Triphenylpyrylium ions entrapped inside the supercages of Y zeolite exert a remarkable catalytic effect toward the electrochemical oxidation of dopamine and norepinephrine (neurotrasmitter catecholamines) in neutral aqueous media. Domenech Carbo, Antonio, Antonio.Domenech@uv.es
The Role of the α Cell in the Pathogenesis of Diabetes: A World beyond the Mirror
2021
Type 2 Diabetes Mellitus (T2DM) is one of the most prevalent chronic metabolic disorders, and insulin has been placed at the epicentre of its pathophysiological basis. However, the involvement of impaired alpha (α) cell function has been recognized as playing an essential role in several diseases, since hyperglucagonemia has been evidenced in both Type 1 and T2DM. This phenomenon has been attributed to intra-islet defects, like modifications in pancreatic α cell mass or dysfunction in glucagon’s secretion. Emerging evidence has shown that chronic hyperglycaemia provokes changes in the Langerhans’ islets cytoarchitecture, including α cell hyperplasia, pancreatic beta (β) cell dedifferentiati…
Fibril formation and toxicity of the non-amyloidogenic rat amylin peptide.
2012
Full-length native rat amylin 1-37 has previously been widely shown to be unable to form fibrils and to lack the toxicity of the human amylin form leading to its use as a non-amyloidogenic control peptide. A recent study has suggested that rat amylin 1-37 forms amyloidogenic β-sheet structures in the presence of the human amylin form and suggested that this property could promote toxicity. Using TEM analysis we show here fibril formation by synthetic rat amylin 1-37 and 8-37 peptides when the lyophilized HPLC purified peptides are initially dissolved in 20 mM Tris-HCl. Dissolution of synthetic rat amylin 1-37 and 8-37 peptides in H(2)O or phosphate buffered saline failed to produce fibrils.…
miR-31-5p Is a LIPUS-Mechanosensitive MicroRNA that Targets HIF-1α Signaling and Cytoskeletal Proteins
2019
The roles of low-intensity pulsed ultrasound (LIPUS) and microRNAs (miRNAs) on hMSCs commitments have already been investigated
Sterigmatocystin-induced cytotoxicity via oxidative stress induction in human neuroblastoma cells.
2020
Abstract Sterigmatocystin (STE) is a mycotoxin produced by fungi of the genus Aspergillus. Considering that the effect of STE on neuronal system has not been well studied, the aim of the present study consists to investigate the cytotoxic effects of STE in human neuroblastoma (SH-SY5Y) cells. Moreover, the role of oxidative stress and intracellular defense systems was assessed by evaluating reactive oxygen species (ROS) generation, lipid peroxidation (LPO) and antioxidant no-enzymatic (GSH) levels and enzymatic (GPx, GST, CAT and SOD) activity. Our results revealed that STE decreased cell viability in a dose and time-dependent manner. Furthermore, after 24 h of exposure, STE induced an incr…