Search results for "ATAL"
showing 10 items of 10591 documents
CoS2/TiO2 Nanocomposites for Hydrogen Production under UV Irradiation
2019
Transition metal chalcogenides have intensively focused on photocatalytic hydrogen production for a decade due to their stronger edge and the quantum confinement effect. This work mainly focuses on synthesis and hydrogen production efficiencies of cobalt disulfide (CoS2)-embedded TiO2 nanocomposites. Materials are synthesized by using a hydrothermal approach and the hydrogen production efficiencies of pristine CoS2, TiO2 nanoparticles and CoS2/TiO2 nanocomposites are compared under UV irradiation. A higher amount of hydrogen production (2.55 mmol g&minus
Molecular Pathways Implicated in Radioresistance of Glioblastoma Multiforme: What Is the Role of Extracellular Vesicles?
2023
Glioblastoma multiforme (GBM) is a primary brain tumor that is very aggressive, resistant to treatment, and characterized by a high degree of anaplasia and proliferation. Routine treatment includes ablative surgery, chemotherapy, and radiotherapy. However, GMB rapidly relapses and develops radioresistance. Here, we briefly review the mechanisms underpinning radioresistance and discuss research to stop it and install anti-tumor defenses. Factors that participate in radioresistance are varied and include stem cells, tumor heterogeneity, tumor microenvironment, hypoxia, metabolic reprogramming, the chaperone system, non-coding RNAs, DNA repair, and extracellular vesicles (EVs). We direct our a…
In tempore Natalis Domini. Incisioni e stampe nei libri liturgici della collezione diocesana dal XVI al XX secolo
2006
Il lavoro costituisce il catalogo, con saggio e schede, di una mostra di manoscritti e libri a stampa dal XV al XX secolo, contenenti illustrazioni sul tema del Natale, con le relative diverse iconografie
Identity politics of the promotional videos of the European Heritage Label
2019
During past decades, the EU has responded to a variety of ‘crises’ by promoting a common cultural heritage to advance European identity and belonging. This article analyses identity politics conducted in the framework of the EU’s flagship heritage action, the European Heritage Label. I borrow from ‘banal nationalism’ to scrutinise the usage of ‘we’ and ‘us’ in the promotional videos of the European Heritage Label sites as subject positions offered for identification in this heritage discourse. Analysis shows that the subject positions are constituted by an emphasis on the national level, preservation of the past for future generations and the key role of experts in the process of heritage. …
Enhancing methane production in a farm-scale biogas production system
2003
Biokaasuteknologiaa pidetään maataloudessa lisääntyvässä määrin lupaavana tekniikkana tuottaa uusiutuvaa energiaa ja minimoida päästöjä ympäristöön. M.Sc. Prasad Kaparaju arvioi väitöstyössään menetelmiä, jotka tehostaisivat metaanintuottoa tilakohtaisessa biokaasuntuotantojärjestelmässä.Hyvin suunniteltu agroteollisuuden jätteiden ja sivutuotteiden käyttö lisää biokaasun tuotantoa maatilakohtaisissa biokaasulaitoksissa ja parantaa ravinteiden kierrätettävyyttä. Maatilakohtaisten prosessien metaanintuotannon maksimoimiseksi työ kohdistui erityyppisten jätemateriaalien metaanintuotannon ja prosessivaikutusten tutkimiseen. Lisäksi tutkittiin erialaisia fysikaalisia ja kemiallisia menetelmiä, …
Superoxide-driven autocatalytic dark production of hydroxyl radicals in the presence of complexes of natural dissolved organic matter and iron
2020
We introduced superoxide as potassium superoxide (KO2) to artificial lake water containing dissolved organic matter (DOM) without or with introduced ferric iron complexes (DOM-Fe), and monitored the production rate of hydroxyl radicals as well as changes in the absorption and fluorescence properties of DOM. The introduction of KO2 decreased the absorption by DOM but increased the spectral slope coefficient of DOM more with complexed ferric Fe than without it. The introduction of KO2 increased the fluorescence of humic-like components in DOM without introduced ferric Fe but resulted in the loss of fluorescence in DOM with introduced ferric Fe. A single introduction of 13 μmol L−1 KO2 produce…
Diastereo- and enantioselective conjugate addition reactions with α,β-usaturated imines
2017
Objetivos Las iminas α,β-insaturadas (1-azabutenos) han sido frecuentemente utilizadas como moléculas de partida para la síntesis de diferentes compuestos nitrogenados. La adición conjugada de nucleófilos carbonados a este tipo de compuestos es una manera eficiente de formar nuevos enlaces C-C dando lugar a la síntesis de enaminas con formación concomitante de un nuevo centro estereogénico. No obstante, al contrario de lo que sucede con los compuestos carbonílicos insaturados y los nitroalquenos, la adición conjugada enantioselectiva de nucleófilos carbonados a iminas α,β-insaturadas ha sido mucho menos estudiada y en particular, no existían ejemplos de adición asimétrica de compuestos 1,3-…
Effects of B-Cell Lymphoma on the Immune System and Immune Recovery after Treatment: The Paradigm of Targeted Therapy
2022
B-cell lymphoma and lymphoproliferative diseases represent a heterogeneous and complex group of neoplasms that are accompanied by a broad range of immune regulatory disorder phenotypes. Clinical features of autoimmunity, hyperinflammation, immunodeficiency and infection can variously dominate, depending on the immune pathway most involved. Immunological imbalance can play a role in lymphomagenesis, also supporting the progression of the disease, while on the other hand, lymphoma acts on the immune system to weaken immunosurveillance and facilitate immunoevasion. Therefore, the modulation of immunity can have a profound effect on disease progression or resolution, which makes the immune syst…
How Can We Improve Vaccination Response in Old People? Part I: Targeting Immunosenescence of Innate Immunity Cells
2022
Vaccination, being able to prevent millions of cases of infectious diseases around the world every year, is the most effective medical intervention ever introduced. However, immunosenescence makes vaccines less effective in providing protection to older people. Although most studies explain that this is mainly due to the immunosenescence of T and B cells, the immunosenescence of innate immunity can also be a significant contributing factor. Alterations in function, number, subset, and distribution of blood neutrophils, monocytes, and natural killer and dendritic cells are detected in aging, thus potentially reducing the efficacy of vaccines in older individuals. In this paper, we focus on t…
Uno studio comparativo in silico sui possibili target di Ataluren e analoghi farmaci promotori di readthrough di codoni di stop prematuri
2019
E’ noto in letteratura che Ataluren (acido 5-(fluorofenil)-1,2,4-ossadiazolil-benzoico) sia in grado di sopprimere le mutazioni non senso favorendo il readthrough dei codoni di stop prematuri, anche se il suo meccanismo di azione non risulta ancora chiaro. La probabile interazione tra Ataluren e CTFR-mRNA è stata precedentemente studiata mediante dinamica molecolare. In questo studio1, abbiamo esteso il modeling del probabile meccanismo di azione di Ataluren mediante approcci computazionali completementari, quali Induced Fit Docking (IFD), Quantum Polarized Ligand Docking (QPLD), metodi MM-GBSA e mutagenesi computazionale. Oltre a considerare il CTFR-mRNA, sono stati presi in considerazione…