Search results for "ATS"
showing 10 items of 6881 documents
Effect of antibodies against cytochrome P-450 on demethylation and denitrosation of N-nitrosodimethylamine and N-nitrosomethylaniline.
1988
Rat liver microsomes which were induced either with ethanol or PB were incubated with NDMA or NMA. Formaldehyde generation and nitrite formation were measured as metabolic parameters for oxidative bioactivation and denitrosation, respectively. The influence of antiserum PB3a1 and PB22 containing antibodies against the corresponding cytochrome P-450 species on both metabolic functions was investigated. The results showed that the influence on formaldehyde production and denitrosation varied independently in that both parameters were either not affected, or influenced in an opposite way, or inhibited to a different degree. Especially remarkable was the 80% inhibition of formaldehyde generatio…
9., 15., 16. un 17. starptautiskā finanšu pārskatu standarta būtiskāko prasību un piemērošanas problēmu izpēte Latvijas Republikas apdrošināšanas sab…
2020
Maģistra darba mērķis ir izstrādāt priekšlikumus 9., 15., 16. un 17. SFPS piemērošanas problēmu risināšanai apdrošināšanas sabiedrībās Latvijā. 2018. un 2019. gadā tika ieviesti trīs jauni SFPS, kas ietekmēja apdrošināšanas sabiedrību finanšu pārskatus. 2023. gadā plānots ieviest 17. SFPS, kas būtiski mainīs līdzšinējo apdrošināšanas līgumu uzskaiti. Līdz ar jaunu SFPS ieviešanu var rasties problēmas, kuras var novērst veicot atbilstošas darbības. Maģistra darbā tiek apskatīta SFPS būtība, apdrošināšanas tirgus darbība un stāvoklis Latvijā, kā arī 9., 15., 16. un 17. SFPS ieviešanas problēmas. Maģistra darba nobeigumā izveidoti secinājumi un priekšlikumi 9., 15., 16. un 17. SFPS ieviešanas …
Sokrata tēls Johana Georga Hāmaņa darbā “Sokratiskās cēldomas”
2016
Šī darba mērķis būs sniegt nelielu ieskatu, kas ir arī kā interpretācija, problemātikā, kas saistīta ar Sokrata tēlu Hāmaņa darbā “Sokratische Denkwürdigkeiten” jeb “Sokratiskās cēldomas”. Lai sasniegtu izvirzīto mērķi, vispirms tiks indentificētas problēmas, kas rodas darbā ar Hāmaņa tekstiem. Sekojoši, tiks ieskicēti daži metodoloģiski apsvērumi, kuri varētu būt noderīgi strādājot ar šādu materiālu. Balstoties uz iegūtajiem secinājumiem, mēģināšu identificēt tēmu lokus, kas varētu būt saistāmi ar Sokrata tēlu. Visbeidzot, pievērsīšos Hāmaņa teksta analīzei, lai iezīmētos tēmu lokus ievietotu kontekstā, kur tie iegūst nozīmi.
Large-scale gene discovery in the pea aphid Acyrthosiphon pisum (Hemiptera)
2006
A large-scale sequencing analysis of the Hemiptera Acyrthosiphon pisumexpressed sequence tags corresponding to about 12,000 unique transcripts is described, along with an in silico profiling analysis that identifies 135 aphid tissue-specific transcripts.
ETC-1002: A future option for lipid disorders?
2014
ETC-1002 is a new investigational low density lipoprotein cholesterol (LDL-C)-lowering agent (Esperion Therapeutics, Inc.). ETC-1002 is a dicarboxylic acid derivative with a novel mechanism of action targeting two hepatic enzymes - adenosine triphosphate-citrate lyase (ACL) and adenosine monophosphate-activated protein kinase (AMPK), inhibiting sterol and fatty acid synthesis and promoting mitochondrial long-chain fatty acid oxidation. This agent is currently in phase II clinical research. Available data report that ETC-1002 significantly decreased LDL-C levels (up to 32%) in both patients with normal and elevated baseline levels of triglycerides. Such beneficial effect is superior to curre…
Amyloid-β toxicity and tau hyperphosphorylation are linked via RCAN1 in Alzheimer's disease.
2011
Amyloid-β peptide (Aβ) toxicity and tau hyperphosphorylation are hallmarks of Alzheimer’s disease (AD). How their molecular relationships may affect the etiology, progression, and severity of the disease, however, has not been elucidated. We now report that incubation of foetal rat cortical neurons with Aβ up-regulates expression of the Regulator of Calcineurin gene RCAN1, and this is mediated by Aβ-induced oxidative stress. Calcineurin (PPP3CA) is a serine-threonine phosphatase that dephosphorylates tau. RCAN1 proteins inhibit this phosphatase activity of calcineurin. Increased expression of RCAN1 also causes up-regulation of glycogen synthase kinase-3beta (GSK3β), a tau kinase. Thus, incr…
Dexamethasone modulates α2-macroglobulin and apolipoprotein E gene expression in cultured rat liver fat-storing (Ito) cells
1991
Fat-storing (Ito) cells are perisinusoidal liver cells thought to play a central role in vitamin A metabolism and fibrogenesis. Glucocorticoids have been shown to be beneficial in the treatment of certain types of liver diseases by delaying the development of cirrhosis. To study the regulatory effects of dexamethasone on Ito cell gene expression, Ito cells were isolated from normal rat liver and primary cultures were established. The effect of dexamethasone on the synthesis of α2-macroglobulin, apolipoprotein E, fibronectin and actin was examined. Protein synthesis was studied both at the protein level and at the RNA level by means of biosynthetic labeling, immunoprecipitation followed by s…
Inhibition of endocannabinoid-degrading enzyme fatty acid amide hydrolase increases atherosclerotic plaque vulnerability in mice
2013
The role of endocannabinoids such as anandamide during atherogenesis remains largely unknown. Fatty acid amide hydrolase (FAAH) represents the key enzyme in anandamide degradation, and its inhibition is associated with subsequent higher levels of anandamide. Here, we tested whether selective inhibition of FAAH influences the progression of atherosclerosis in mice. Selective inhibition of FAAH using URB597 resulted in significantly increased plasma levels of anandamide compared to control, as assessed by mass spectrometry experiments in mice. Apolipoprotein E-deficient (ApoE(-/-)) mice were fed a high-fat, cholesterol-rich diet to induce atherosclerotic conditions. Simultaneously, mice recei…
Effect of rat plasma high density lipoprotein with or without apolipoprotein E on the cholesterol uptake and on the induction of the corticosteroid b…
1991
Abstract High density lipoprotein (HDL) has been shown to induce the cellular accumulation of cholesterol esters and the biosynthesis of 21-hydroxysteroids (corticosteroids) newborn rat adrenocortical cells cultivated in serum-free medium. In order to identify the component(s) of HDL responsible for these effects, we investigated the ability of rat HDL subfractions and HDL with or without apolipoprotein E to deliver cholesterol to cells and to stimulate the steroid biosynthetic pathways in adrenal cultured cells. The total cholesterol uptake from HDL 2 was greater than that observed with HDL rich in apolipoprotein E (HDL 1 and HDL c ). Furthermore, the increase of the ratio between 21-hydro…
Opposite vascular activity of (R)-apomorphine and its oxidised derivatives. Endothelium-dependent vasoconstriction induced by the auto-oxidation meta…
2003
We have synthetised a series of oxidised apomorphine derivatives (orto and para quinones 2-5), in order to analyse their vascular activity. We have performed radioligand binding assays on rat cortical membranes and functional studies on rat aortic rings. Instead the relaxant activity exhibited by (R)-apomorphine, o-quinones 2, 4, show contractile activity dependent on endothelium in rat aortic rings. Compound 2, the main metabolite of (R)-apomorphine auto-oxidation, was the product which showed enhanced contractile activity by a complex mechanism related to activation of Ca(2+) channels through release and/or inhibition of endothelial factors. Moreover, this compound disrupts the endothelia…