Search results for "ATS"
showing 10 items of 6881 documents
The brainstem efferent acoustic chiasm in pigmented and albino rats
2015
Abstract The present study examined whether structural peculiarities in the brain-efferent pathway to the organ of Corti may underlie functional differences in hearing between pigmented and albino individuals of the same mammalian species. Pigmented Brown-Norway rats and albino Wistar rats received unilateral injections of an aqueous solution of the retrograde neuronal tracer Fluorogold (FG) into the scala tympani of the cochlea to identify olivocochlear neurons (OCN) in the brainstem superior olivary complex. After five days, brains were perfusion-fixed and brainstem sections were cut and analyzed with respect to retrogradely labeled neurons. Intrinsic neurons of the lateral system were lo…
Latvijas Universitātes 2015.gada publiskais pārskats
2016
Šajā pārskatā ir apvienoti: 1. Gada publiskais pārskats (LR Likuma par budžetu un finanšu vadību 14.panta 3.punkts; 05.05.2010. Ministru kabineta noteikumi Nr.413 „Noteikumi par gada publiskajiem pārskatiem”); 2. Zinātniskās institūcijas gada publiskais pārskats (LR Zinātniskās darbības likuma 40.pants; 16.05.2006. Ministru kabineta noteikumi Nr.397 „Noteikumi par zinātnisko institūciju reģistrā reģistrētā zinātniskā institūta gada publisko pārskatu”); 3. Gadagrāmata (LR Augstskolu likuma 75.pants). Pārskats ir sagatavots, izmantojot datus no LU fakultāšu, zinātnisko institūtu, studiju centru un LU aģentūru iesniegtajiem pārskatiem, LUIS datus, kā arī LU administratīvo un patstāvīgo akadēmi…
On the Difference Between Necessary and Unnecessary Glances Away From the Forward Roadway : An Occlusion Study on the Motorway
2019
Objective The present study strove to distinguish traffic-related glances away from the forward roadway from non-traffic-related glances while assessing the minimum amount of visual information intake necessary for safe driving in particular scenarios. Background Published gaze-based distraction detection algorithms and guidelines for distraction prevention essentially measure the time spent looking away from the forward roadway, without incorporating situation-based attentional requirements. Incorporating situation-based attentional requirements would entail an approach that not only considers the time spent looking elsewhere but also checks whether all necessary information has been sampl…
Efficacy of the antioxidant ebselen in experimental uveitis.
1999
Inflammation results in the production of free radicals. In a model of experimental uveitis upon subcutaneous injection of endotoxin to Lewis rats, i.e., endotoxin-induced experimental uveitis (EIU), we have evaluated the status of the antioxidant capacity of ocular tissues. EIU results in a decrease of glutathione (GSH) content and glutathione peroxidase (GPx) activity in whole eye homogenates 24-h after endotoxin administration. Furthermore, an increase in malondialdehyde (MDA) content was observed in these same samples, thus confirming the involvement of oxidative stress in the pathophysiology of the process. In view of the ability of the antioxidant ebselen as GPx enzyme mimic, we teste…
Some aspects of cardiac antioxidant defence: Ebselen (PZ 51) treatment increases glutathione peroxidase activity in the rat heart
1990
Ebselcn (PZ 5 1 : 2-phenyl1.2-benzisoelenazol-3-( 2H)-one 1 is ii synthetic organoselenium compound with anti-inflammatory activity ( I . 21, which exhibits glutathione peroxidase (GSH-Px)-like activity, catalysing the reduction o f hydrogen peroxide as well as other organic peroxides [3-5]. Its antiinflammatory effect may be mediated by either the GSH-Px activity, the inhibition of leukotriene B4 formation [6], the antioxidant capacity, or a combination of all of them. Many attempts have been made to increase the antioxidant capacity of the myocardium, since free radical generation has been demonstrated in ischaemia-reperfusion damage [7, 81; superoxide dismutase (SOD) and catalase have be…
Single-dose ebselen does not afford sustained neuroprotection to rats subjected to severe focal cerebral ischemia
2004
Oxygen free radicals have been involved in the pathophysiology of cerebral ischemia, especially after spontaneous or thrombolytic reperfusion. In this study with rats, we have combined a severe focal ischemic insult (2 h) and a prolonged reperfusion time (7 days) to assess the possible sustained neuroprotective effect of ebselen (10 or 100 mg/kg), a small, lipophilic organoselenium compound which mimics glutathione peroxidase. Parietal cortical perfusion was measured by laser-Doppler flowmetry, and focal cerebral ischemia was carried out by the intraluminal thread method. We have measured plasma selenium levels, brain reduced glutathione levels, as a marker of oxidative stress, and infarct …
Ebselen prevents chronic alcohol-induced rat hippocampal stress and functional impairment
2007
Background: Most of the previously published data suggest a role for oxidative or nitrosative stress in ethanol-induced nervous system damage. Moreover, ethanol is able to impair learning abilities in adult mammalian brain, a process suggested to be directly related to hippocampal neurogenesis. Ebselen, a synthetic compound with antioxidant properties, is able to prevent ethanol-induced impairment of neurogenesis in adult rats. The aim of the present work was to further demonstrate the ability of ebselen to prevent biochemical alterations, and preserve long-term potentiation (LTP) and learning abilities, in the hippocampus of chronic alcoholic adult rats. Methods: Biochemical markers of oxi…
Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3.
2009
The Hsc/Hsp70 co-chaperones of the BAG (Bcl-2-associated athanogene) protein family are modulators of protein quality control. We examined the specific roles of BAG1 and BAG3 in protein degradation during the aging process. We show that BAG1 and BAG3 regulate proteasomal and macroautophagic pathways, respectively, for the degradation of polyubiquitinated proteins. Moreover, using models of cellular aging, we find that a switch from BAG1 to BAG3 determines that aged cells use more intensively the macroautophagic system for turnover of polyubiquitinated proteins. This increased macroautophagic flux is regulated by BAG3 in concert with the ubiquitin-binding protein p62/SQSTM1. The BAG3/BAG1 ra…
Work rhythm, flow and success in a project : a case study research
2013
Masteroppgave i økonomi og administrasjon - Universitetet i Agder 2013 Organisations and individuals are shaped and influenced by their environment and interaction with others in a conscious or unconscious manner. Due to increased competitiveness, organisations need to be aware of elements in their environment and how these can affect operations and outcomes. Rhythms in organisations and the employee’s work rhythms are considered to influence flow and the achieved level of success in organisations. This thesis aims to investigate factors setting the work rhythms for organisations and individuals, and to study whether work rhythms influence flow and level of success. Our research question wa…
Sustainable strategies: Integrating sustainability practices into corporate business operations : How can companies in polluting industries develop a…
2019
Master's thesis Business Administration BE501 - University of Agder 2019 This thesis seeks to study how companies within polluting industries can develop and implement profitable and sustainable business strategies. In order to answer the given research question, the shipping and cruise line industry is the chosen industry of study, due to its air and water pollutions. Research on the field states that the strategic management process of companies within the industry is rather challengingand addresses the need for further studies. The literature identified a gap between the development and implementation phases, with the latter stated as most difficult for the strategic manager. Therefore, …