Search results for "AV-153-Ca"

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1,4 dihidropiridinski derivati povećavaju ekspresiju gena Psma3, Psmb5 i Psmc6 u glasničkoj RNA štakora

2021

The ubiquitin-proteasome system modifies different cellular and protein functions. Its dysregulation may lead to disrupted proteostasis associated with multiple pathologies and aging. Pharmacological regulation of proteasome functions is already an important part of the treatment of several diseases. 1,4-dihydropyridine (1,4-DHP) derivatives possess different pharmacological activities, including antiaging and neuroprotective. The aim of this study was to investigate the effects of several 1,4-DHP derivatives on mRNA expression levels of proteasomal genes Psma3, Psmb5, and Psmc6 in several organs of rats. Rats were treated with metcarbatone, etcarbatone, glutapyrone, styrylcarbatone, AV-153…

glutapironDihydropyridinesProteasome Endopeptidase Complexetcarbatoneporemećena proteasomska funkcijaimpaired proteasomal functionsproteasome subunitsToxicologyPSMA3metkarbatonKidneyNeuroprotectionPSMC6glutapyroneAV-153-NaAV-153-Ca; AV-153-Na; etcarbatone; gene expression; glutapyrone; impaired proteasomal functions; metcarbatone; pharmacological activities; proteasome subunits; styrylcarbatone; ubiquitin-proteasome systemAV-153-Ca; AV-153-Na; etkarbaton; glutapiron; metkarbaton; stirilkarbaton; poremećena proteasomska funkcija; proteasomske podjedinice; ubikvitin-proteasomski sustavGene expressionAnimalsstyrylcarbatoneRNA MessengerGeneChemistryPublic Health Environmental and Occupational HealthPSMB5Cell biologyproteasomske podjediniceRatsProteostasisProteasomeubikvitin-proteasomski sustavstirilkarbatongene expressionOriginal Articlepharmacological activitiesAV-153-Caubiquitin-proteasome systemmetcarbatoneetkarbatonArchives of Industrial Hygiene and Toxicology
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