Search results for "AXL"
showing 6 items of 16 documents
Laser ultrasonics for defect evaluation on coated railway axles
2020
Abstract This scientific paper focuses on the application of an advanced non-destructive technique for an effective inspection of railway axles. The method pertains to ultrasonic techniques, which are widely used in the railway field. The experimental investigation was carried out on simulated defects tooled near the cross section reduction of the axle, in order to simulate fatigue cracks which, due to notch effect, can trigger crack propagation and axle failure. The aim of this research activity is to evaluate how efficiently the proposed technique detects defects and to verify its applicability to axles with a black coating for protection. In view of the experimental setup, comprising a p…
Directional Shuttling of a Stimuli-Responsive Cone-Like Macrocycle on a Single-State Symmetric Dumbbell Axle
2018
Rotaxane-based molecular shuttles are often operated using low-symmetry axles and changing the states of the binding stations. A molecular shuttle capable of directional shuttling of an acid-responsive cone-like macrocycle on a single-state symmetric dumbbell axle is now presented. The axle contains three binding stations: one symmetric di(quaternary ammonium) station and two nonsymmetric phenyl triazole stations arranged in opposite orientations. Upon addition of an acid, the protonated macrocycle shuttles from the di(quaternary ammonium) station to the phenyl triazole binding station closer to its butyl groups. This directional shuttling presumably originates from charge repulsion and an …
Algorithms for Pallet Building and Truck Loading in an Interdepot Transportation Problem
2016
This paper deals with the problem of a logistics company that has to serve its customers by first putting the products on pallets and then loading the pallets into trucks. Besides the standard geometric constraints of products not overlapping each other and not exceeding the dimensions of pallets and trucks, in this real problem, there are many other constraints, related to the total weight of the load, the maximum weight supported by each axle, and the distribution of the load inside the truck. Although the problem can be decomposed into two phases, pallet loading and truck loading, we have taken a combined approach, building and placing pallets at the same time. For each position in the t…
Mathematical models for multicontainer loading problems
2017
Abstract This paper deals with the problem of a distribution company that has to serve its customers by putting first the products on pallets and then loading the pallets onto trucks. We approach the problem by developing and solving integer linear models. We start with basic models, that include the essential features of the problem, such as respecting the dimensions of the truck, and not exceeding the total weight capacity and the maximum weigh capacity on each axle. Then, we add progressively new conditions to consider the weight and volume of pallet bases and to include other desirable features for the solutions to be useful in practice, such as the position of the center of gravity and…
Overcoming resistance to HER2 blockade in breast cancer: AXL as a promising druggable target and prognostic biomarker
2022
Introduction: Breast cancer is a heterogeneous disease consisting of uncontrolled growth of epithelial cells originating in the ducts or breast lobules. It is currently the most diagnosed cancer worldwide and the fifth cause of cancer-related death in general population, but the first cause in women. Breast cancer incidence is higher in developed countries due to increased risk factors and to increased and earlier detection by mammography screening, which considerably reduces mortality. This is the reason why transitioning countries have higher mortality despite having lower incidence. Regarding the origin of the disease, it is evidenced that the pathways implicated in normal development of…
Nuevas vías moleculares implicadas en los mecanismos de resistencia primaria y adquirida en cáncer de mama HER2 positivo
2018
El cáncer de mama es el tumor más frecuente en la mujer, representa aproximadamente el 28% de todas las neoplasias y es la principal causa de muerte por cáncer en las mujeres europeas. A pesar de los avances en el tratamiento y en el diagnóstico temprano, sigue siendo un importante problema de salud pública. El 20% de las pacientes diagnosticadas de cáncer de mama presentan una recaída. La enfermedad en estadios avanzados sigue siendo incurable con una supervivencia media de 2-3 años y una supervivencia global de 25% a los 5 años. El cáncer de mama es una enfermedad heterogénea que podemos clasificar en: luminal A, luminal B, HER2 amplificado o triple negativo en función de criterios anatom…