Search results for "Absolute"
showing 10 items of 518 documents
Four great magnalia of government. La riforma istituzionale di Henry Neville: un machiavelliano inglese alla corte di Cosimo III de’ Medici
2021
The tumultuous phase running from the beheading of Charles I to the Glorious Revolution is the time frame in which England goes through the crucial phases that will put an end to royal absolutism. One of the most authoritative intellectual figures of that founding historical moment of modern constitutionalism is Henry Neville, author of political and satirical pamphlets who, taking up the lesson of the ancients with the experience of “modern things”, published in 1680 the Plato Redivivus, a work that will consecrate him as a Republican political thinker. The treaty, written and published in the context of the Exclusion crisis, exhort Charles II to reduce his powers. The disease suffered by…
Cultural policy regimes and arts councils. Thelongue duréeperspective, birth of the state, religious trajectories and national cultural policies
2021
The cultural policy orientation of European countries has usually been interpreted in the light of political ideological factors or the model of the welfare state. However, while these dimensions e...
Thermische Diels-Alder-Reaktionen mitN-(2-Alkenoyl)-(S)-prolinestern als chiralen Dienophilen in organischen und wäßrigen Reaktionsmedien
1990
Thermal Diels-Alder Reactions with N-(2-Alkenoyl)-(S)-proline Esters as Chiral Dienophiles Cyclopentadiene reacts with N-acryloyl-(S)-proline benzyl and allyl ester in toluene at 0°C to give the bicycloheptene-carboxylic acid amides with a stereoselection of (2S):(2R) = 81:19. In the reactions with the N,N′-fumaroylbis(proline esters) the cycloadducts are formed in high yields and with isomer ratios of up to 97:3. The absolute configuration of N,N′-〈(1R,2R,3R,4S)-bicyclo[2.2.1]hept-5-ene-2,3-diyldicarbonyl〉bis-[(S)-proline benzyl ester] (6 a) has been determined by an X-ray analysis. In the reactions of the acrylamides with cyclopentadiene and of the fumaramides with cyclopentadiene, isopre…
Novel σ1 antagonists designed for tumor therapy: Structure – activity relationships of aminoethyl substituted cyclohexanes
2021
Abstract Depending on the substitution pattern and stereochemistry, 1,3-dioxanes 1 with an aminoethyl moiety in 4-position represent potent σ1 receptor antagonists. In order to increase the stability, a cyclohexane ring first replaced the acetalic 1, 3-dioxane ring of 1. A large set of aminoethyl substituted cyclohexane derivatives was prepared in a six-step synthesis. All enantiomers and diastereomers were separated by chiral HPLC at the stage of the primary alcohol 7, and their absolute configuration was determined by CD spectroscopy. Neither the relative nor the absolute configuration had a large impact on the σ1 affinity. The highest σ1 affinity was found for cis-configured benzylamines…
Acid-induced rearrangement of epoxygermacra-8,12-olides: synthesis and absolute configuration of guaiane and eudesmane derivatives from artemisiifolin
2010
A study on the acid-induced rearrangement of 4,5-epoxy- and 1,10-epoxygermacra-8,12-olides was carried out. From a 4,5-epoxy derivative, guaianes were obtained, whereas 1,10-epoxy derivatives furnished, depending on the stereochemistry of the C-1/C-10 epoxy ring, trans-5β,10α- or trans-5α,10β-eudesmanolides.
Schelling’s pantheism and the problem of evil
2017
ABSTRACTAny religious worldview, understood in the sense that ‘life has a purpose’, has to face the problem of evil. The problem of evil has been particularly intensively discussed in the Aristotelian–Scholastic–Christian tradition. The most popular solution has been to deny that anything truly evil actually exists. It is hard to conceive why an omnipotent and perfectly good God would allow evil to appear. Yet, Western culture has been and still is full of imagery of absolute demonic evil. I suggest that this strained dialectic could be best approached by radically rethinking the nature of evil and the theological context in which it has traditionally been thought. In his middle period work…
Stereoselective Synthesis of Chiral Piperidine Derivatives Employing Arabinopyranosylamine as the Carbohydrate Auxiliary.
2006
Stereoselective synthesis of 2-substituted dehydropiperidinones and their further transformation to variously disubstituted piperidine derivatives was achieved employing D-arabinopyranosylamine as the stereodifferentiating carbohydrate auxiliary. A domino MannichMichael reaction of 1-methoxy-3-(trimethylsiloxy)butadiene (Danishefsky's diene) with O-pivaloylated arbinosylaldimines furnished N-arabinosyl dehydropiperidinones in high diastereoselectivity. Subsequent conjugate cuprate addition gave 2,6-cis-substituted piperidinones, while enolate alkylation furnished 2,3-trans-substituted dehydropiperidinones. Electrophilic substitution at the enamine structure afforded 5-nitro- and 5-halogen…
Anomalous pressure dependence of the Lamb-Mössbauerf-factor in the spin crossover system [Fe(2-pic-ND2)3]Cl2·EtOD
1987
The pressure dependence of the Lamb-Mossbauer factor of the spin crossover compound [Fe(2-pic-ND2)3]Cl2·EtOD(2-pic-ND2=2-picolylamine, deuterated at the−NH2 group) has been measured at pressures up to 1500 bar and at three temperatures (115.7, 146.7, 185.6 K) around the transition temperatureT t=135 K. The temperature dependence of the unit cell volume has been determined by X-ray diffraction. In the transition region (T=146.7 K), the pressure dependence of thef-factor shows an anomalous increase as compared to the dependence below and above the transition. The behaviour off(p, T), its anomaly and absolute value, can be consistently explained within a theoretical model which treats the comp…
Structural characterization of carane derivative stereoisomers - Potent local anesthetics
2002
The paper reports on structural investigation and phase analysis of a newly synthesized potent local anesthetic with chiral molecular structure. Absolute structure and absolute configuration on four chiral centres was determined using microcrystalline single-crystal difracti on with anomalous scattering of X-ray radiation azimuthal scan technique. Phase analysis for new compound (K P23SS) and its epimer (K P23 RS) was carried out using classical and synchrotron radiation powder difraction. Enantiopurity of the bulk material was verifed for both isomers by comparison of experimental and simulated high- resolution powder difraction diagrams. The presence of two new polymorphic phases of K P23…
Human Dignity and Legally Protected Goods in Criminal Law
2020
Criminal law protects certain basic goods because they are directly or indirectly connected with the dignity of the person. However, in cases such as euthanasia, prostitution or surrogacy motherhood, the appeal to the dignity of the person is used, in the opposite sense, as the basis for decriminalization. In these cases, dignity is identified with the autonomy of the person and their capacity to dispose of all their goods, even if they are essential. This work argues that there is an ontological core of dignity (requirement of absolute respect) that is subtracted from autonomy and that is protected by the concept of ‘moral integrity’. It prevents certain conducts from being decriminalized …