Search results for "Absorption"

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysin…

2016

Three Physiologically Based Pharmacokinetic software packages (GI-Sim, Simcyp® Simulator, and GastroPlus™) were evaluated as part of the Innovative Medicine Initiative Oral Biopharmaceutics Tools project (OrBiTo) during a blinded “bottom-up” anticipation of human pharmacokinetics. After data analysis of the predicted vs. measured pharmacokinetics parameters, it was found that oral bioavailability (Foral) was underpredicted for compounds with low permeability, suggesting improper estimates of intestinal surface area, colonic absorption and/or lack of intestinal transporter information. Foral was also underpredicted for acidic compounds, suggesting overestimation of impact of ionisation on pe…

Nanoencapsulation in Lipid-Core Nanocapsules Controls Mometasone Furoate Skin Permeability Rate and Its Penetration to the Deeper Skin Layers

2013

<b><i>Aims:</i></b> The influence of nanoencapsulation of mometasone furoate (MF) in poly(ε-caprolactone) lipid-core nanocapsules (LNC) on its in vitro human skin permeation and penetration was evaluated. <b><i>Methods:</i></b> Semisolid formulations were prepared by increasing the viscosity of LNC using a carbomer (Carbopol® Ultrez at 0.5% w/v). Two complementary techniques (the static Franz diffusion cell model and the Saarbrücken penetration model) were used to evaluate skin permeation/penetration. <b><i>Results:</i></b> The drug release rate was decreased by nanoencapsulation. The skin permeability of MF was control…

Lipid-lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel

2017

In recent years, there has been growing interest in the possible use of nutraceuticals to improve and optimize dyslipidemia control and therapy. Based on the data from available studies, nutraceuticals might help patients obtain theraputic lipid goals and reduce cardiovascular residual risk. Some nutraceuticals have essential lipid-lowering properties confirmed in studies; some might also have possible positive effects on nonlipid cardiovascular risk factors and have been shown to improve early markers of vascular health such as endothelial function and pulse wave velocity. However, the clinical evidence supporting the use of a single lipid-lowering nutraceutical or a combination of them is…

Bis(stilbenyl)squaraines — Novel pigments with extended conjugation

1996

Abstract We report on the synthesis of a novel type of squaraines ( 11a-f, 17c ) in which the conjugation of the chromophore is extended by stilbene units. These pigments exhibit absorption bands which have their maxima at the end on the Vis region and reach partly into the NIR.

ChemInform Abstract: Bis(stilbenyl)squaraines. Novel Pigments with Extended Conjugation.

2010

Abstract We report on the synthesis of a novel type of squaraines ( 11a-f, 17c ) in which the conjugation of the chromophore is extended by stilbene units. These pigments exhibit absorption bands which have their maxima at the end on the Vis region and reach partly into the NIR.

Temperature dependence of the absorption properties of silanol groups in amorphous SiO2: Are silanol groups organized in clusters?

2011

Bi3+doping in 1D ((CH3)3SO)PbI3: A model for defect interactions in halide perovskites

2022

The recently described monodimensional hybrid pseudo-perovskite ((CH3)3SO)PbI3 exhibits complete Pb2+/Bi3+ miscibility in the B site. Heterovalent substitution imposes that charge-compensating defects are introduced in the lattice as well. This paper reports the energetics of point defects and the interaction between charge-compensating defects that occur upon Bi3+ doping in ((CH3)3SO)PbI3. Periodic DFT simulations were employed to analyze the formation energy of Pb2+ vacancies, (CH3)3SO+ vacancies, iodide vacancies, or the insertion of interstitial iodide ions. Solid solutions with a large Bi3+ content were modeled considering different charge compensation defects (Pb2+ vacancies, (CH3)3SO…

Ultracompact x-ray dosimeter based on scintillators coupled to a nano-optical antenna

2017

International audience; We show that nano-optical antennas are capable of controlling the luminescence induced by the absorption of x rays into matter. The x-ray-excited luminescence from a tiny scintillation cluster coupled to a horn nano-optical antenna is highly directed and determined by the antenna’s geometrical parameters. Directionality is sufficiently high to efficiently outcouple the x-ray-excited luminescence to a narrow single-mode optical fiber, thus enabling ultracompact fiber-integrated x-ray sensors. Our nano-optically driven approach offers the possibility of x-ray profiling and dosimetry in ultra-confined environments, opening up new avenues in the fields of x-ray imaging, …

Assessment of the quality of the air in the city of Palermo through chemical and cell analyses on Pinus Needles

2001

The influence of air pollution on the chemical composition of Pinus sp. needles was examined in polluted and control sites in and around the city of Palermo (Sicily). The chemical composition of needles indicated the extent of contamination of the trees, which were cytologically examined. Cell analysis was carried out on pine samples, including needles and pollens, from 15 different locations. Biostructural and spectrophotometric tests were performed. In particular, concentrations of toxic (Cd, Pb) and non-toxic metals (Fe,Cu, Zn) were determined, as well as injury caused by their accumulation in the needles. The more highly urbanised areas showed higher concentrations of metals (Pb, Cu. Zn…

Stress-induced cytological and chemical adaptations in Cupressus plants from an urban area of Palermo (Italy)

2004

We studied stress-induced cytological and chemical adaptations in Cupressus pollens and needles from the area of Palermo (Sicily, Italy), in polluted and control sites (unpolluted) of urban and suburban areas. Pollen and needle chemical composition were investigated to provide an indicator of contamination of the trees, which were also examined structurally throughout one year. The concentration of particulate with lead was found to be significantly higher in plants at the polluted traffic site. Lead is one of the worst particulate pollutants in cities, especially in the winter season. In trees from the polluted site, all structural analysis revealed displasies. Structural changes, observed…