Search results for "Abstracts"

HEALTH AND PHYSICAL FUNCTIONING AS DETERMINANTS OF PURPOSE IN LIFE IN OLD AGE

2018

AbstractPurpose in life reflects the feeling of having goals and meaning in life. Higher purpose in life has been shown to predict better health outcomes in old age and even buffer against mortality. However, it is not known how current health and functional status reflect on the possibilities of older people to live a meaningful life. Therefore, this study aimed to explore associations of health and physical functioning with purpose in life. The participants were 273 community-dwelling 75-year-old men and women from the AGNES study. Purpose in life was assessed with the subscale of the Scales of Psychological well-being (range 7–42). Current health situation and walking ability were self-r…

AGING IN PLACE WITH INTELLECTUAL DISABILITY: CARE TRANSITIONS AMONG OLDER TWO-GENERATION FAMILIES

2017

Little is known of transitions in care and housing of old two-generation families that include aging (≥40) adults with intellectual disability (ID) and their older (≥65) parents. This study employed the “housing pathways” theory in order to explore the experiences of these families of such transitions. All potential old two-generation families from two local authorities in Taiwan were recruited; 237 families completed our survey and 61 our in-depth interviews between May 2015 and July 2016. Different models and types of transitions in care and housing of these families were identified and found to be connected with changes in their care responsibilities and living arrangements. Old parents …

THE HEALTHY NORDIC DIET AMONG OLDER INDIVIDUALS PREDICTS INCIDENT DISABILITY IN A 10-YEAR FOLLOW-UP

2017

We investigated whether adherence to the healthy Nordic diet among older individuals was associated with incident disability 10 years later. We studied 972 participants from the Helsinki Birth Cohort Study who were free of disability at baseline. At the mean age of 61 years the Nordic diet score (NDS) was calculated based on a validated food-frequency questionnaire that the participants filled in. Higher scores indicated better adherence to the healthy Nordic diet. At the mean age of 71 years, participants’ incident disability was assessed using a self-reported questionnaire and was based on two levels of disability: mobility difficulty (difficulty in walking 500 m) and self-care dependence…

EFFECTS OF A HOME-BASED REHABILITATION PROGRAM ON HEALTH-RELATED QUALITY OF LIFE

2017

Health-Related Quality of life (HRQoL) decreases after a hip fracture (HF) and may remain low for a long time. Knowledge is needed on effective rehabilitation strategies after HF. Purpose of this study was to investigate the effects of individualized home-based rehabilitation on HRQoL among community-dwelling older people after HF.

CHILDHOOD ADVERSITIES AND HOME ATMOSPHERE AS DETERMINANTS OF DISABILITY AND UNEMPLOYMENT PENSION

2017

Childhood adversities have been linked with adverse life events, but less is known about the long-term effects of childhood home atmosphere in terms of work career. We investigated whether childhood adversities and home atmosphere were associated with disability or unemployment pension. In the Helsinki Birth Cohort Study (born 1934–44), 2001 cohort members had data available on 9 childhood home atmosphere items e.g. whether it was supportive or warm (sum score 0–36, higher score indicating more favorable atmosphere), and 9 childhood adversities e.g. unemployment, parent’s long-term illness or divorce (sum score 0–9, coded into no; one; and two or more) assessed in 2001–04. Of those, 1528 ha…

ARE BAD JOBS INEVITABLE? A COMPARATIVE STUDY OF AGED-CARE OCCUPATIONS AND TRAINING

2017

As the population ages globally, the care of older adults with chronic disease and physical and cognitive impairment will require a significantly larger and more skilled direct care workforce than currently exists. Many countries have migration policies to encourage workers to leave home and perform this important work. Others relegate the majority of the labor to vulnerable populations including women of color and immigrants. Do these jobs have to be “bad jobs” with poor compensation, few benefits and heavy workloads? This study comparatively examines the demographic composition and extrinsic characteristics of entry-level aged care jobs in select countries: U.S., Canada, United Kingdom, A…

TRTH-08. HIGH GRADE NEUROEPITHELIAL TUMOR OF THE CENTRAL NERVOUS SYSTEM WITH BCOR ALTERATION IS SENSITIVE TO IGF1R INHIBITION

2017

High grade neuroepithelial tumor of the central nervous system with BCOR alteration (CNS HGNET-BCOR) is a recently described new tumor entity which was formerly diagnosed with diverse histological diagnoses, for example as ependymoma. This tumor predominantly affects children and has a dismal prognosis. No standard therapies for this entity exist so far. Recently we described the activation of the Sonic hedgehog (SHH) and the WNT signaling pathway in this tumor and described a primary cell culture (PhKh1) isolated from a skull metastasis of a seven years old patient. We also detected a high expression of IGF2, which is known to be required for SHH signaling in medulloblastoma. IGF2 signals …

International Society for Therapeutic Ultrasound Conference 2016

2017

NCOG-10. FACTORS INFLUENCING NEUROCOGNITIVE FUNCTION IN PATIENTS WITH NEUROEPITHELIAL TUMORS

2017

Though cognitive function is proven to be an independent predictor of survival in patients with intrinsic brain tumors, higher cognitive functions are still seldom studied. Aim of this study was to assess neurocognitive function and to identify risk factors for neurocognitive deficits in patients with intrinsic brain tumors. 103 patients with primary neuroepithelial tumors who received tumor resections or biopsies were included in this prospective study. The following data was acquired: mini-mental state examination, preoperative tumor volume, WHO grade, tumor entity and location, and the Karnofsky performance status scale. Furthermore, patients conducted an extensive neuropsychological tes…

ACTR-58. PHASE III TRIAL OF CCNU/TEMOZOLOMIDE (TMZ) COMBINATION THERAPY VS. STANDARD TMZ THERAPY FOR NEWLY DIAGNOSED MGMT-METHYLATED GLIOBLASTOMA PAT…

2017

There is an urgent need for more effective therapies in glioblastoma (GBM). Data from the single arm UKT-03 trial (Glas et al., J Clin Oncol 27, 1257, 2009) suggested that combined lomustine/temozolomide (CCNU/TMZ) therapy might have superior activity in MGMT-methylated GBM. The phase III CeTeG/NOA-09 trial was set up to test this hypothesis in a randomized setting. Patients with MGMT-methylated GBM were randomized (1:1) for standard therapy with daily TMZ (75 mg/m2) during local radiotherapy (RT, 30 x 2 Gy) followed by 6 courses of TMZ (150–200 mg/m2/day for 5 days q4w) or experimental therapy with CCNU/TMZ in addition to local RT. Six 6-week courses of CCNU/TMZ (CCNU 100 mg/m2 d1, TMZ 100…