Search results for "Acemetacin"
showing 2 items of 2 documents
Quality control of pharmaceuticals containing non-steroidal anti-inflammatory drugs by micellar liquid chromatography
2002
A liquid chromatographic procedure is described for the determination of acemetacin, diclofenac, indomethacin, ketoprofen, nabumetone, naproxen, piketoprofen, and tolmentin in pharmaceutical preparations. The compounds were separated on a Kromasil C18 analytical column, with a guard column of similar characteristics; the mobile phase was 0.06 M cetyltrimethylammonium bromide, at pH 7, containing 10% 1-butanol. At a flow rate of 1 mL min−1 the elution time of the most retained compound was 23 min. Limits of detection were between 0.01 μ g mL−1 for diclofenac and 0.2 μ g mL−1 for naproxen. The proposed method enables the determination of non-steroidal anti-inflammatory drugs in pharmaceutical…
Comparison between sodium dodecylsulphate and cetyltrimethylammonium bromide as mobile phases in the micellar liquid chromatography determination of …
2004
The retention behaviour of non-steroidal anti-inflammatory drugs (NSAIDs) using micellar mobile phases of sodium dodecylsulphate (SDS) is studied and compared with that observed with micellar mobile phases of cetyltrimethylammonium bromide (CTAB). A liquid chromatographic procedure for the determination of acemetacin, diclofenac, indomethacin, ketoprofen, naproxen and tolmetin in pharmaceutical preparations is described. The proposed system uses a Kromasil C18 analytical column and a solution of 0.15 M SDS at pH 3 with 10% 1-propanol as mobile phase. Under these conditions, the studied NSAIDs elute between 6 and 10 min at a 1 mL min(-1) flow rate. Limits of detection (LOD) are lower than 0.…