Search results for "Acholi"

Deep inspiration-induced bronchoprotection is stronger than bronchodilation

2000

We have previously shown that in healthy subjects, deep inspiration (DI) has not only a bronchodilatory but also a bronchoprotective effect that is absent in asthmatic subjects. We conducted the study reported here to test the hypothesis that the bronchoprotective effect is stronger than the bronchodilatory effect, and to determine the extent to which these two effects are related. Ten healthy subjects underwent provocations in which single doses of methacholine, previously shown to reduce FEV(1) by 10% to 20% (Dose 1) and by 20% to 40% (Dose 2) were administered after a 20-min period devoid of DI. To measure the bronchodilator effect, DIs were performed immediately after the first spiromet…

Maximal Response Plateau to Adenosine 5′-Monophosphate in Asthma

2009

Background No information is available on the plateau in response to adenosine 5′-monophosphate. The aims of the present study were to determine whether plateau can be detected with AMP and the relation with the plateau in response to methacholine, and to identify the relation between the plateau and indirect markers of airway inflammation, such as exhaled nitric oxide (ENO) and exhaled breath condensate (EBC) pH. Methods Airway responsiveness to high concentrations of methacholine and AMP, ENO levels, and EBC pH values were obtained in 31 subjects with well-controlled asthma. Concentration-response curves were characterized by their concentration of agonist that produces a decrease in FEV …

BMI can influence adult males' and females' airway hyperresponsiveness differently

2012

Abstract Background Epidemiological data indicate that obesity is a risk factor for asthma, but scientific literature is still debating the association between changes in body mass index (BMI) and airway hyperresponsiveness (AHR). Methods This study aimed at evaluating the influence of BMI on AHR, in outpatients with symptoms suggestive of asthma. 4,217 consecutive adult subjects (2,439 M; mean age: 38.2±14.9 yrs; median FEV1 % predicted: 100 [IQR:91.88-107.97] and FEV1/FVC % predicted: 85.77% [IQR:81.1-90.05]), performed a methacholine challenge test for suspected asthma. Subjects with PD20 20 20 > 800 were considered affected by severe, moderate or mild AHR, respectively. Results A total …

The airway response to deep inspirations decreases with COPD severity and is associated with airway distensibility assessed by computed tomography.

2008

In patients with mild chronic obstructive pulmonary disease (COPD), the effect of deep inspirations (DIs) to reverse methacholine-induced bronchoconstriction is largely attenuated. In this study, we tested the hypothesis that the effectiveness of DI is reduced with increasing disease severity and that this is associated with a reduction in the ability of DI to distend the airways. Fifteen subjects [Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage I–II: n = 7; GOLD stage III–IV: n = 8] underwent methacholine bronchoprovocation in the absence of DI, followed by DI. The effectiveness of DI was assessed by their ability to improve inspiratory vital capacity and forced expira…

A divided country : microhistorical perspective to the presidents and authority in Uganda

2008

Tämän tutkimuksen tarkoituksena on tarkastella Ugandan yhteiskunnan kehitystä kahden eri kysymyksen kautta: Kuinka pohjoisen ja etelän jako on kehittynyt itsenäisyyden aikana sekä millainen on acholi-heimon asema Ugandan politiikassa? Tutkimus kuvaa narratiivien avulla eri presidenttien valtakausia sekä näiden kahden ilmiön kehitystä. Metodologisesti tutkimus hyödyntää mikrohistorian muunnelmaa yhdessä Max Weberin auktoriteettikäsitteiden sekä Christopher Claphamin mukaisen uus-patrimonialismin käsitteen kanssa. Kysymysten tarkastelu on jaettu jaksoihin, jotka vastaavat Ugandan presidenttien virkakausia. Tutkimuksen päämateriaali koostuu poliittisista elämänkerroista ja kirjallisuusmateriaa…

The Lord’s Resistance Army and the arms that brought the Lord : amplifying polyphonic silences in northern Uganda

2019

This article develops the notion of polyphonic silence as a means for thinking through the ethical and political ramifications of ethnographically encountering and writing about silenced violent pasts. To do so, it analyses and contrasts the silence surrounding two periods of extreme violence in northern Uganda: 1) the northern Ugandan war (1986–2006), which is contemporarily often shrouded by silence, and 2) the early decades of colonial and missionary expansion, which the Catholic church silences in its commemoration of the death of two Acholi catechists in 1918. Employing the notion of polyphony, the article describes how neither of these silences is a mere absence of narration. Instead,…

Effect of allergen-specific immunotherapy with purified Alt a1 on AMP responsiveness, exhaled nitric oxide and exhaled breath condensate pH: a random…

2010

Abstract Background Little information is available on the effect of allergen-specific immunotherapy on airway responsiveness and markers in exhaled air. The aims of this study were to assess the safety of immunotherapy with purified natural Alt a1 and its effect on airway responsiveness to direct and indirect bronchoconstrictor agents and markers in exhaled air. Methods This was a randomized double-blind trial. Subjects with allergic rhinitis with or without mild/moderate asthma sensitized to A alternata and who also had a positive skin prick test to Alt a1 were randomized to treatment with placebo (n = 18) or purified natural Alt a1 (n = 22) subcutaneously for 12 months. Bronchial respons…

Airway Distensibility by HRCT in COPD Patients

2006

The loss of the beneficial effect of deep inspiration (DI) in COPD is associated with severity of disease

2007

Different muscarine receptors mediate the prejunctional inhibition of [3H]-noradrenaline release in rat or guinea-pig iris and the contraction of the…

1989

To investigate the muscarine receptor type mediating inhibition of [3H]-noradrenaline release from the isolated rat and guinea-pig iris we have determined the potency of antimuscarinic drugs to antagonize the methacholine-induced inhibition of [3H]-noradrenaline overflow evoked by field stimulation (3 Hz, 2 min). The prejunctional apparent affinities were compared with those obtained for postjunctional muscarine receptors mediating the methacholine-induced contraction of the isolated rabbit iris sphincter muscle. Prejunctional apparent affinity constants of pirenzepine (6.67), himbacine (8.51), methoctramine (7.92), 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP, 8.00), hexahydro-d…