Search results for "Acide"
showing 10 items of 100 documents
The study of calcium signaling in lipid gustatory cells in mice
2012
The lipid-binding glycoprotein CD36, expressed by circumvallate papillae (CVP) of the mouse tongue, has been shown to be implicated in oro-gustatory perception of dietary lipids. We demonstrate that linoleic acid (LA) by activating sPLA2, cPLA2 and iPLA2 via CD36, produced arachidonic acid (AA) and lyso-phosphatidylcholine (Lyso-PC) which triggered Ca2+ influx in CD36-positive taste bud cells (TBC), purified from mouse CVP. LA induced the production of Ca2+ influx factor (CIF). CIF, AA and Lyso-PC exerted different actions on the opening of store-operated Ca2+ (SOC) channels, constituted of Orai proteins and regulated by STIM1, a sensor of Ca2+ depletion in the endoplasmic reticulum. We use…
Cellular metabolic alteration : the voice of monoinsaturated fatty acid as therapeutic target
2010
Stearoyl Co-A desaturase (SCD) is the key enzyme of the metabolism of mono-unsaturated fatty acids (MUFA). Its activity 9 desaturase introduces a double bond cis in position 9 of saturated fatty acids (SFA), induced formation of MUFA. Impaired biosynthesis of MUFA is involved in many diseases such as cancer and cardiovascular disease. Cancer cells have a de novo synthesis of fatty acids increased with an accumulation MUFA. This change in the metabolism of fatty acids is associated with overexpression SCD1 which catalyzes the conversion of saturated fatty acids, monounsaturated fat. Several reports have shown that inhibition of SCD1 leads to blockage of proliferation and induction of apopt…
Réponses comportementales et préférences envers les acides gras à longue chaîne chez Drosophila melanogaster
2011
Fatty-acids (FAs) are crucial for animal survival and reproduction since these molecules are involved in many metabolic pathways and constitute a substantial store of energy. Despite the strong relationship established between excessive FA consumption and severe human etiologies (obesity, cancer, vascular diseases), our knowledge of the mechanisms underlying FA perception and preference is limited particularly in invertebrates. This is one of the reasons why we decided to investigate, during our PhD thesis, the perception of long-chain FAs (C14:0, C16:0, C18:0, C18:1, C18:2, C18:3), using the model species Drosophila melanogaster. We have also attempted to characterize some of the biologica…
Plasmalogen metabolism in retinal glial cells : interaction between cells during normal or pathological vascular development
2017
Retinal vascular disorders such as retinopathy of prematurity (ROP), diabetic retinopathy or age-related macular degeneration represent the first cause of vision loss at all ages in industrialized countries. Many epidemiological or animal studies have shown the involvement of polyunsaturated fatty acids (PUFA) in the regulation of vascular development and more specifically the beneficial properties of omega 3 PUFA (n-3 PUFA) against pathological vascularization. Those PUFA are esterified on glycerophospholipids (GP). GP are the primary constituents of the lipid bilayer of cell membranes. PUFA can be also esterified on a specific class of GP, called plasmalogens. Plasmalogens are characteriz…
Involvement of plasmalogens and polyunsaturated fatty acids in the pathogenesis of glaucoma
2013
Flavour of dairy products
1987
International audience
Impact d’une carence en soufre sur la composition protéique des graines d’une collection de pois (Pisum sp.)
2019
Un miracle transformateur de goût : la miraculine, potentiel prometteur pour l'industrie agroalimentaire
2016
Connaissez-vous le fruit miracle ?Non, non, il n’est pas ici question d’un pays magique, ni d’un phénomène cosmique : il s’agit bel et bien d’un nom de fruit existant sur notre planète, aux ressources parfois surprenantes.Ne soyez pas sceptique : une fois informés sur ses étonnantes propriétés, je mets ma main à couper que vous aimeriez en savoir plus, voire même, le goûter.Car le fruit miracle contient une protéine (logiquement appelée « la miraculine ») aux attributs uniques : transformer le goût de l’acide en goût sucré… sans aucun sucre ajouté.Un potentiel prometteur pour des applications industrielles en agroalimentaire. Je vous propose d’en apprendre plus avec Loïc Briand, directeur d…