Search results for "Acromegaly"
showing 10 items of 40 documents
Visceral Adiposity Index: An Indicator of Adipose Tissue Dysfunction
2013
The Visceral Adiposity Index (VAI) has recently proven to be an indicator of adipose distribution and function that indirectly expresses cardiometabolic risk. In addition, VAI has been proposed as a useful tool for early detection of a condition of cardiometabolic risk before it develops into an overt metabolic syndrome. The application of the VAI in particular populations of patients (women with polycystic ovary syndrome, patients with acromegaly, patients with NAFLD/NASH, patients with HCV hepatitis, patients with type 2 diabetes, and general population) has produced interesting results, which have led to the hypothesis that the VAI could be considered a marker of adipose tissue dysfuncti…
Visceral Adipose function, insulin sensitivity and secretion in active acromegaly.
2011
Increased central corneal thickness in acromegalic patients.
2009
Visfatin as a marker of adipose dysfunction and metabolic impairment in active acromegaly and its possible use during the follow-up
2015
Background Visfatin is an adipokine with insulin-mimetic and adipogenic effect related to insulin resistance (IR) and visceral adipose mass. Although acromegaly is characterized by both adipose dysfunction and IR, data on visfatin levels in acromegaly are very scarce and in the few existing studies no difference was reported between acromegalic patients and controls. Aim To evaluate the visfatin levels in acromegaly in relation to disease activity and type of treatment. Subjects and Methods Data of 56 patients (31 M, age 59 ± 12 yrs) were analyzed. Sixteen patients were newly diagnosed (ND), while the remaining were in therapy with somatostatin analogues (SA, 21), pegvisomant (PE, 12) and a…
Janus kinase (JAK) 2 V617F mutation as the cause of primary thrombocythemia, severe visceromegaly and divergence between growth hormone and insulin-l…
2011
Usefulness and safety of pasireotide in a case of acromegaly highly resistant to treatment.
2015
Background: Pasireotide is a novel somatostatin analogue with higher affinity to 4/5 known human somatostatin receptors subtypes. It could have utility in acromegalic patients not responding to available treatments, although a deterioration in glucose metabolism is described during its use. Case: We describe our experience in the management of a case of a 41 years-old man affected by mixed GH-PRL secreting pituitary macroadenoma (32 mm) high resistant to different treatments. At baseline, the patient showed GH nadir after OGTT 26 ng/ml, IGF-1 1369 ng/dl, PRL 2386 ng/ml, normal glucose tolerance (NGT) with HbA1c 5.9%. Eight months of pre-operative treatment with monthly lanreotide LA 120 mg …
Complete biochemical control and oituitary adenoma disappearance in a child with gigantism: efficay of octreotide therapy
2011
2018
Objective: Acromegalic patients display a distinct neuropsychological profile and suffer from chronic physical complaints. We aimed to investigate in more detail these aspects in acromegalic patients, dependent on influencing factors like disease activity, age, sex, chronic medication, surgery, pituitary radiation, pituitary insufficiency and comorbidities. Design: Cross sectional, multicentric. Methods: 129 patients (M/W 65/64, 58.3 ± 12.7 years, 53/76 with active/controlled disease). Acromegalic patients completed the following inventories: NEO-FFI, IIP-D, and the Giessen Complaints List (GBB-24), after written informed consent. Age, sex, IGF-1 concentrations, comorbidities, treatment mod…
Diabetes Secondary to Acromegaly: Physiopathology, Clinical Features and Effects of Treatment.
2018
Acromegaly is a rare disease due to chronic GH excess and to the consequent increase in IGF-1 levels. Both GH and IGF-1 play a role in intermediate metabolism affecting glucose homeostasis. Indeed, chronic GH excess impairs insulin sensitivity, increases gluconeogenesis, reduces the glucose uptake in adipose tissue and muscle and alters pancreatic β cells function. As a consequence, glucose metabolism alterations are a very frequent complication in acromegaly patients, further contributing to the increased cardiovascular risk and mortality. Treatment modalities of acromegaly differently impact on glucose tolerance. Successful surgical treatment of acromegaly ameliorates glucose metabolism a…