Search results for "Acrylates"
showing 5 items of 115 documents
Oligo(glycerol) Methacrylate Macromonomers
2011
Linear, protected ω-methoxy oligo(glycerol) methacrylate (OGly(P)MA) macromonomers are synthesized via anionic ring-opening polymerization of ethoxyethyl glycidyl ether (EEGE) followed by termination with methacrylic acid anhydride (DP(n) = 3-11, PDI < 1.30). The covalently bound methacrylate moiety allows the homopolymerization of OGly(P)MA as well as copolymerization with low molecular weight comonomers. In homopolymerizations, macromonomers are polymerized by atom transfer radical polymerization (ATRP) yielding well-defined graft polymers (M(n) = 20,000-30,000 g mol(-1)). Acidic hydrolysis of the protecting groups releases water-soluble polyhydroxy-functional structures. First results on…
Generation of anti-azoxystrobin monoclonal antibodies from regioisomeric haptens functionalized at selected sites and development of indirect competi…
2012
Azoxystrobin is a modern strobilurin fungicide used around the world to combat prime diseases affecting highly valuable crops. Accordingly, residues of this chemical are frequently found in food, even though mostly under maximum tolerated levels. We herein describe the development of an indirect competitive immunoassay for the determination of azoxystrobin residues. A panel of monoclonal antibodies displaying subnanomolar affinity to azoxystrobin was generated using, as immunizing haptens in mice, four functionalized derivatives carrying the same spacer arm located at different rationally chosen positions. This collection of antibodies was thoroughly characterized with homologous and hetero…
Synthesis of azoxystrobin transformation products and selection of monoclonal antibodies for immunoassay development
2012
The use of agrochemicals for crop protection may result in the presence of toxic residues in soils and aquatic environments, besides in foodstuffs. Most often just the parent compound is included in the definition of pesticide residue, even though chemicals resulting from biotransformation and degradation routes might also be of toxicological relevance. Azoxystrobin is a broad-spectrum systemic fungicide widely used worldwide to combat pathogenic fungi affecting plants. We herein report the synthesis and detailed chemical characterization of several of the most relevant metabolites and degradates of azoxystrobin. These compounds were further employed as ligands for screening a collection of…
The European multicenter cohort study on cyanoacrylate embolization of refluxing great saphenous veins
2014
ObjectiveCyanoacrylate (CA) embolization of refluxing great saphenous veins (GSVs) has been previously described. The outcomes from a multicenter study are still lacking.MethodsA prospective multicenter study was conducted in seven centers in four European countries to abolish GSV reflux by endovenous CA embolization. Neither tumescent anesthesia nor postinterventional compression stockings were used. Varicose tributaries remained untreated until at least 3 months after the index treatment. Clinical examination, quality of life assessment, and duplex ultrasound evaluation were performed at 2 days and after 1, 3, 6, and 12 months.ResultsIn 70 patients, of whom 68 (97.1%) were available for 1…
Transcatheter embolization of the kidney with butyl-2-cyanoacrylate: Experimental and clinical results
1978
The technique and efficacy of therapeutic catheter embolization of the kidney with butyl-2-cyanoacrylate (Histoacryl) were studied in 80 rabbits (including control groups) and in 10 dogs. A mixture of butyl-2-cyanoacrylate, 50% glucose, and tantalum powder was used for the embolization. Complete and permanent vascular occlusion was found in nearly all cases. The main complication observed was a reflux of embolizing material into the lumbar arteries, which occurred in seven rabbits. Clinically, therapeutic embolization was performed in six patients with hypernephroma. The indication for embolization in these patients, as well as in two others with iatrogenic lesions, was pronounced hematuria…