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Significant interaction between high-dose methotrexate and high-dose piperacillin-tazobactam causing reversible neurotoxicity and renal failure in an…
2020
Introduction Pharmacokinetic interaction of high-dose methotrexate (MTX) and other concomitantly administered renally secreted medicinal products may lead to insufficient methotrexate serum level decrease and significant MTX toxicity. Case report We report the case of an 18-year-old male patient treated with high-dose MTX for an osteosarcoma and with high-dose piperacillin-tazobactam at the same time. MTX serum levels were severely elevated 24 hours after the MTX infusion and did not decrease in accordance with the specific calcium folinate rescue protocol. The patient experienced renal failure accompanied by neurological symptoms, most consistent with MTX-related renal and CNS toxicity. Ma…
Patterns of trunk spine growth in two congeneric species of acanthocephalan: investment in attachment may differ between sexes and species.
2012
SUMMARYAcanthocephalans have evolved a hooked proboscis and some taxa have trunk spines to attach to their definitive hosts. These structures are generated before being used, thus a key question is how investment in attachment could optimally be allocated through the ontogeny. The number and arrangement of hooks and spines are never modified in the definitive host, but it is unclear whether these structures grow during adult development. A comparison of the size of trunk spines between cystacanths and adults of Corynosoma cetaceum and C. australe indicated that spines grow in both species, but only in females, which also had significantly larger spines than males. This sexual dimorphism did…
All Eyes on Me : Behaving as Soloist in Duo Performances Leads to Increased Body Movements and Attracts Observers’ Visual Attention
2020
Duo musicians exhibit a broad variety of bodily gestures, but it is unclear how soloists’ and accompanists’ movements differ and to what extent they attract observers’ visual attention. In Experiment 1, seven musical duos’ body movements were tracked while they performed two pieces in two different conditions. In a congruent condition, soloist and accompanist behaved according to their expected musical roles; in an incongruent condition, the soloist behaved as accompanist and vice versa. Results revealed that behaving as soloist, regardless of the condition, led to more, smoother, and faster head and shoulder movements over a larger area than behaving as accompanist. Moreover, accompanists …
Le società: le società mutualistiche: gli istituti transtipici - vol. 3
2019
The book proposes a study of mutual companies and extraordinary corporate operations, with an institutional approach
Management of Statin Intolerance in 2018: Still More Questions Than Answers.
2018
Statin therapy is generally well tolerated and very effective in the prevention and treatment of cardiovascular disease, regardless of cholesterol levels; however, it can be associated with various adverse events (myalgia, myopathy, rhabdomyolysis, and diabetes mellitus, among others). Patients frequently discontinue statin therapy without medical advice because of perceived side effects and consequently increase their risk for cardiovascular events. In patients with statin intolerance, it may be advisable to change the dose, switch to a different statin, or try an alternate-day regimen. If intolerance is associated with all statins—even at the lowest dose—non-statin drugs and certain nutra…
La circulation des termes dans le discours médiatique : peut-on informer sans déformer ?
2016
Media diversification and information superhighways that have become faster and faster have boosted the circulation of economic terms in the popular press, along with the interaction between editorial contents targeted at the general population, which are similar in nature. This twin phenomenon of circulation and interaction was highlighted in a contrastive study of the way the German and the French press managed the euro crisis between 2011 and 2013: articles devoted to the debt of countries that are going through hard economic times require expert knowledge, but also resort to popularization strategies that show multi-level interdiscursivity.
The Major Heat Shock Proteins, Hsp70 and Hsp90, in 2-Methoxyestradiol-Mediated Osteosarcoma Cell Death Model
2020
2-Methoxyestradiol is one of the natural 17&beta
Phenomenology of non-standard neutrino interactions
2016
Today neutrino physics is in a privileged position within the fascinating field of particle physics. From the discovery of neutrino oscillations by Super-Kamiokande in 1998, the door to physics beyond the Standard Model (SM in what follows) has been opened. This fact implies that neutrinos have to be massive in opposition to the Standard Model assumption. However, this is not a surprise completely, but it was already hinted from theoretical and experimental observations in the two decades prior to the discovery of the oscillatory phenomenon, as neutrino masses included in unification models or the observed deficit of the atmospheric and solar neutrino fluxes. As a consequence of this new pa…
Search for Neutrino Non-Standard Interactions with the KM3NET/ORCA 6 Lines Detector
2022
En el Modelo Estándar, que es la teoría establecida de las interacciones fundamentales, no se contempla que los neutrinos tengan masa. La mayoría de las extensiones teóricas postuladas del Modelo Estándar dirigidas a la inclusión de masas de neutrinos requieren la existencia de un nuevo tipo de interacciones que aún no se ha observado. Desde el punto de vista fenomenológico, estas interacciones se pueden agrupar bajo el concepto de interacciones no estándar de neutrinos (INE o NSIs por sus siglas en inglés) que afectarían la oscilación de neutrinos a un nivel secundario. El experimento KM3NeT/ORCA es un telescopio de neutrinos de próxima generación destinado a medir las oscilaciones de los …