Search results for "Activity"

DEVELOPMENT AND QUALIFICATION OF BIOANALYTICAL METHODS FOR DEAMIDATED IFNβ-1a AND INVESTIGATION ABOUT THE MECHANISM OF ACTION

2021

Interferon beta-1a (IFNβ-1a) is a recombinant IFNβ with the tradename Rebif involved in several biological activities. Recently, it has been reported that artificial deamidation of IFNb-1a increases its biological response. Given the therapeutical potential, an investigation on the deamidated variant has been carried out via different approaches to discover the mechanism underlying this biological effect. The antiviral and immunomodulatory activity of deamidated cytokine was assessed using two precise and accurate cell-based assays. As expected, deamidated IFNβ-1a showed an increase in the biological response and its canonical pathway and receptor binding affinity were thorough analysed. De…

Reactivity of 4-Aminopyridine with Halogens and Interhalogens : Weak Interactions Supported Networks of 4-Aminopyridine and 4-Aminopyridinium

2019

The reaction of 4-aminopyridine (4-AP) with ICl in a 1:1 molar ratio in CH2Cl2 produced the expected charge-transfer complex [4-NH2-1λ4-C5H4N-1-ICl] (1·ICl) and the ionic species [(4-NH2-1λ4-C5H4N)2-1μ-I+][Cl–] (2·Cl–) in a 2:1 relation, as indicated by 1H NMR spectroscopy in solution. In contrast, only the ionic compound [(4-NH2-1λ4-C5H4N)2-1μ-I+][IBr2–] (2·IBr2–) was observed in the analogous reaction with IBr. The reaction between 4-AP and I2 in a 1:1 molar ratio also afforded two components, one of which was identified as the congeneric cation in [(4-NH2-1λ4-C5H4N)2-1μ-I+][I7–] (2·I7–) that contains a polyiodide anion as a result of transformation in a 1:2 molar ratio between the starti…

Comunicare l'archeologia: innovazioni multimediali negli allestimenti museali

2014

Negli ultimi anni il tema della comunicazione museale attraverso i più avanzati strumenti di comunicazione è diventato, per i museografi, di forte interesse progettuale. Da diversi anni viene condotto infatti un dibattito molto acceso sui metodi e mezzi di comunicazione a supporto della narrazione archeologica in continuo contrasto fra tradizionalisti e rinnovatori, sul rapporto tra gli oggetti e la multimedialità e sul museo come luogo di apprendimento e divertimento. La ricerca approfondisce l'uso e il ruolo delle nuove tecnologie di comunicazione concentrandosi sulla possibilità di inserimento di essi negli allestimenti a carattere archeologico. Negli ultimi anni, i new media hanno appor…

Snacktivity™ to promote physical activity and reduce future risk of disease in the population: protocol for a feasibility randomised controlled trial…

2023

Abstract Background Many people do not regularly participate in physical activity, which may negatively impact their health. Current physical activity guidelines are focused on promoting weekly accumulation of at least 150 min of moderate to vigorous intensity physical activity (MVPA). Whilst revised guidance now recognises the importance of making small changes to physical activity behaviour, guidance still focuses on adults needing to achieve at least 150 min of MVPA per week. An alternative ‘whole day’ approach that could motivate the public to be more physically active, is a concept called Snacktivity™. Instead of focusing on achieving 150 min per week of physical activity, for example …

Couches minces d'oxynitrure de titane : la réactivité comme moyen original de caractérisation physico - chimique

2002

Titanium oxinitride thin films, TiNxOy, were elaborated on Si(100) by the MOCVD (Metal Organic Chemical Vapor Deposition) method, using titanium isopropoxide Ti(OCH(CH3)2)4 and ammonia NH3 as precursors. By varying the growth temperature, it is possible to modify the N/O ratio and change the conductivity of the films.The target of this work was to determine the composition and the structure of these TiNxOy thin films in order to understand the electrical properties. However, this study was difficult because classical characterization techniques (SEM, XRD, Raman, XPS...) were unable to describe the whole TiNxOy system. Indeed, only a structure which is isomorphic to TiN (NaCl structure) was …

Mononuclear rearrangement of heterocycles in ionic liquids catalyzed by copper(II) salts

2008

Abstract The reactivity of E- and Z-phenylhydrazones of 3-benzoyl-5-phenyl-1,2,4-oxadiazole in the presence of CuCl2 and Cu(ClO4)2·6H2O has been studied in four imidazolium ionic liquids [bmim][X] (X=BF4−, PF6−, SbF6− and CF3SO3−). The reaction may follow different mechanistic patterns, depending on the nature of the ionic liquid anion, accounting for both qualitative and kinetic data. In the presence of CuCl2, two processes take place at the same time, i.e., the E⇆Z isomerization and the rearrangement of Z-isomer into the relevant 4-benzoylamino-2,5-diphenyl-1,2,3-triazole. In contrast, in the presence of Cu(ClO4)2·6H2O, the rearrangement occurs only in solution of [bmim][BF4] and [bmim][C…

Can the absence of solvation of neutral reagents by ionic liquids be responsible for the high reactivity in base-assisted intramolecular nucleophilic…

2005

[reaction: see text] The kinetics of the rearrangement of the Z-phenylhydrazone of 3-benzoyl-5-phenyl-1,2,4-oxadiazole (1a) into the relevant 4-benzoylamino-2,5-diphenyl-1,2,3-triazole (2a) induced by amines have been studied in two room-temperature ionic liquids (IL-1, [BMIM][BF4] and IL-2, [BMIM][PF6]). The data collected show that the reaction occurs faster in ionic liquids than in other conventional solvents previously studied (both polar or apolar, protic or aprotic). Presumably, this could depend on their peculiar ability to minimize the strong substrate-solvent, amine-solvent and amine-amine interactions occurring in conventional solvents.

Correlates of Sedentary Behaviour in Adults with Intellectual Disabilities : A Systematic Review

2018

Teenage Time Use and Educational Attainment in Adulthood in Finland

2021

We investigated the role of teenage everyday social ties in educational outcomes by examining the association between teenage time use and educational attainment in adulthood. The sample consisted of young people aged 10–18 from the 1979 Finnish Time Use Survey, and the same respondents’ educational attainment later in life recorded from population register data at the year of 40th birthday (n = 366 men and 393 women). We assessed the associations of time spent with the parents, on studying, leisure activities, as well as social connectedness with friends and participation in extracurricular activities, with educational outcomes. Our findings indicated that time spent with the father is pos…

Integrating Self-Reports and Electrodermal Activity (EDA) Measurement in Studying Emotions in Professional Learning

2022

Studies on emotions in learning have been mostly conducted through self-reporting questionnaires and interviews conducted after the learning situation, which seldom focus on professional workplace learning. Meanwhile, workplace and professional learning research has been introduced with emerging methods to capture the learning processes at multiple levels. Previous research on emotions has suggested that self-reports should be supplemented with psychophysiological data. Challenged by this, this chapter aims to present and discuss the integration of self-reported and psychophysiological data in studying emotions and professional learning. The empirical research data are obtained from five Fi…