Search results for "Activity"
showing 10 items of 7178 documents
Piloting a Smart Rollator : User experiences with technology-related motivation and physical activity
2021
Background: Improved life expectancy combined with suboptimal physical activity (PA)represents an increasingly salient public health challenge among the elderly. PA in late life is associated with fewer health problems in old age. Assistive information and communication technology might improve PA and alleviate health problems among the elderly.Objective: This pilot study aimed to quantitatively measure the motivational aspects relatedto rollator use and, by using qualitative interviews, outline how a Smart Rollator solution would motivate older adults to increase their PA in their everyday lives.Method: A total of 19 subjects between the ages of 63 and 91 years participated in the study. H…
Comparison of adjuvant and adjuvant-free murine experimental asthma models
2009
Introduction The most widely used protocol for the induction of experimental allergic airway inflammation in mice involves sensitization by intraperitoneal (i.p.) injections of the antigen ovalbumin (OVA) used in conjunction with the adjuvant aluminium hydroxide (alum). Although adjuvants are frequently used, there are questions regarding the necessity of alum for murine asthma studies due to the non-physiological nature of this chemical. Objective The objective of this study was to compare experimental asthma phenotypes between adjuvant and adjuvant-free protocols of murine allergic airway inflammation in an attempt to develop a standardized alternative to adjuvant use. Method An adjuvant-…
Granulocyte-macrophage colony-stimulating factor (CSF) and multilineage CSF recruit human monocytes to express granulocyte CSF
1989
Abstract We assessed the capacity of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) and multilineage (Multi)-CSF to induce release of granulocyte-CSF (G-CSF) by highly purified peripheral blood monocyte (Mo) preparations. Our results reveal that GM-CSF and Multi-CSF, either alone or in a synergistic concert, activate Mo to transcribe G-CSF messenger (m) RNA and release biologically active G- CSF protein into their culture supernatants. G-CSF had no regulatory effect on Mo expression of cytoplasmic G-CSF mRNA levels and G-CSF protein secretion by itself. These differential actions of CSFs provide further insight into self-regulatory mechanisms within the growth f…
A pyrroloquinazoline derivative with anti-inflammatory and analgesic activity by dual inhibition of cyclo-oxygenase-2 and 5-lipoxygenase
2002
Abstract In a previous study, we reported a new pyrroloquinazoline derivative, 3-(4′-acetoxy-3′,5′-dimethoxy)benzylidene-1,2-dihydropyrrolo[2,1- b ]quinazoline-9-one (PQ), which inhibited human purified 5-lipoxygenase activity and prostaglandin E 2 release in lipopolysaccharide-stimulated RAW 264.7 cells. In the present work, we show that PQ inhibits cyclo-oxygenase-2 activity in intact cell assays (human monocytes) and purified enzyme preparations (ovine isoenzymes) without affecting cyclo-oxygenase-1 activity. This behaviour was confirmed in vivo by using the zymosan-injected mouse air pouch model, where PQ caused a marked reduction in cell migration and leukotriene B 4 levels at 4 h, as …
A single mutation in the recombinant light chain of tetanus toxin abolishes its proteolytic activity and removes the toxicity seen after reconstituti…
1994
Specific proteolysis by the tetanus toxin light chain of a vesicle-associated membrane protein (VAMP) involved in exocytosis is thought to underlie its intracellular blockade of neurotransmitter release. To substantiate this mechanism, recombinant light chain was expressed as a maltose binding protein-light chain fusion product in Escherichia coli. After purification of affinity chromatography and cleavage with factor Xa, the resultant light chain was isolated and its identity confirmed by Western blotting and N-terminal sequencing. It exhibited activity similar to that of the native light chain in proteolyzing its target in isolated bovine small synaptic vesicles and in hydrolyzing a 62-re…
Physical activity reduces the risk of pneumonia : systematic review and meta-analysis of 10 prospective studies involving 1,044,492 participants
2022
The beneficial effects of regular physical activity in promoting health and preventing chronic diseases are well documented. The relationship between regular physical activity and the risk of pneumonia is uncertain. We aimed to evaluate the magnitude and specificity of the prospective association between regular physical activity and the risk of pneumonia using a systematic review and meta-analysis of published observational cohort studies in general populations. Relevant studies with at least 1 year of follow-up were sought from inception until 15 September 2021 in MEDLINE, Embase, Web of Science, and manual search of relevant articles. Relative risks (RRs) with 95% confidence intervals (C…
Phosphorus-Chalcogen Ring Expansion and Metal Coordination
2017
The reactivity of 4-membered (RPCh)2 rings (Ch = S, Se) that contain phosphorus in the +3 oxidation state is reported. These compounds undergo ring expansion to (RPCh)3 with the addition of a Lewis base. The 6-membered rings were found to be more stable than the 4-membered precursors, and the mechanism of their formation was investigated experimentally and by density functional theory calculations. The computational work identified two plausible mechanisms involving a phosphinidene chalcogenide intermediate, either as a free species or stabilized by a suitable base. Both the 4- and 6-membered rings were found to react with coinage metals, giving the same products: (RPCh)3 rings bound to the…
Leisure activities and well-being in midlife and older age with special reference to physical activity and resistance training
2019
Participation in leisure activities is related to better well-being. Participation in leisure time physical activity also has several positive effects on functional capacity and health. Notwithstanding, only a minor proportion of adults, including older adults, participate in physical activity at a sufficient level for maintaining or improving their health. This study investigated both cross- sectional and longitudinal associations between different types of leisure and physical activities and well-being. This dissertation is based on data from three research projects: the Finland 2014 – Consumption and Lifestyle postal survey, conducted with a random sample representative of the Finnish ad…
Rethinking visual art practice in relation to well-being : a conceptual analysis
2015
This study examines how the concepts related to visual art practice and well-being have been used in the arts and academic sectors. Furthermore, it studies whether it is possible to create a new theoretical and conceptual framework for research. The research material of the arts and academic sectors was examined by the methods of critical review and conceptual analysis. The conceptual analysis led to the following main results: The employment of the concepts concerning the practice of visual arts was diverse, often overlapping, and in some respects incoherent. Both the concepts of ‘art’ and ‘well-being’ were mostly used as reasoning with generalizations. This strategy of discourse was conce…
Aktywność zawodowa kobiet na obszarach migracyjnych województwa opolskiego
2021
Jednym z czynników wpływających na aktywność zawodową ludności są procesy migracyjne. Województwo opolskie jako region o długich tradycjach migracyjnych od lat charakteryzował się niską aktywnością zawodową kobiet. Na obszarach objętych intensywnymi migracjami zarobkowymi mężczyzn, bezrobocie kobiet było bardzo wysokie. Wynikało ono z jednej strony z niskiego udziału mężczyzn wśród ogółu bezrobotnych, a z drugiej – z celowego utrzymywania statusu osoby bezrobotnej przez kobiety, który gwarantował m.in. dostęp do świadczeń zdrowotnych. Wzmożone wyjazdy w celach zarobkowych kobiet na początku XXI w. były odpowiedzią na wzrost zapotrzebowania na kobiecą siłę roboczą w tzw. sektorze usług rodzi…