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ELECTRICAL DISCHARGE MACHINING - A HIGH FUTURE NONCONVENTIONAL PROCESSING PROCESS
2021
Electrical discharge machining is one of the most common processes for processing metallic materials. This process is characterized by the lack of mechanical pressure on the object that ensures the macroscopic location of the erosive agent. This scientific paper highlights a study based on experimental data processing as well as modeling the most important technological parameters for dimensional processing by electrical discharge machining with and without magnetic activation. In this context, the modeling and optimization of process parameters is approached, which can lead to the quality increasing of the processed surface, to an increase of the processing productivity and to a reduction …
Highly occupied gauge theories in 2 + 1 dimensions : a self-similar attractor
2019
Motivated by the boost-invariant Glasma state in the initial stages in heavy-ion collisions, we perform classical-statistical simulations of SU(2) gauge theory in 2+1 dimensional space-time both with and without a scalar field in the adjoint representation. We show that irrespective of the details of the initial condition, the far-from-equilibrium evolution of these highly occupied systems approaches a unique universal attractor at high momenta that is the same for the gauge and scalar sectors. We extract the scaling exponents and the form of the distribution function close to this non-thermal fixed point. We find that the dynamics are governed by an energy cascade to higher momenta with sc…
Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity
2011
Normal tissue damage limits the efficacy of anticancer therapy. For anthracyclines, the clinically most relevant adverse effect is cardiotoxicity. The mechanisms involved are poorly understood and putative cardioprotectants are controversially discussed. Here, we show that the lipid-lowering drug lovastatin protects rat H9c2 cardiomyoblasts from doxorubicin in vitro. Protection by lovastatin is related to inhibition of the Ras-homologous GTPase Rac1. It rests on a reduced formation of DNA double-strand breaks, resulting from the inhibition of topoisomerase II by doxorubicin. Doxorubicin transport and reactive oxygen species are not involved. Protection by lovastatin was confirmed in vivo. I…
Tiam1 as a Signaling Mediator of Nerve Growth Factor-Dependent Neurite Outgrowth
2010
Nerve Growth Factor (NGF)-induced neuronal differentiation requires the activation of members of the Rho family of small GTPases. However, the molecular mechanisms through which NGF regulates cytoskeletal changes and neurite outgrowth are not totally understood. In this work, we identify the Rac1-specific guanine exchange factor (GEF) Tiam1 as a novel mediator of NGF/TrkA-dependent neurite elongation. In particular, we report that knockdown of Tiam1 causes a significant reduction in Rac1 activity and neurite outgrowth induced by NGF. Physical interaction between Tiam1 and active Ras (Ras- GTP), but not tyrosine phosphorylation of Tiam1, plays a central role in Rac1 activation by NGF. In add…
Rac1 and PAK1 are upstream of IKK-ε and TBK-1 in the viral activation of interferon regulatory factor-3
2004
The anti-viral type I interferon (IFN) response is initiated by the immediate induction of IFN beta, which is mainly controlled by the IFN-regulatory factor-3 (IRF-3). The signaling pathways mediating viral IRF-3 activation are only poorly defined. We show that the Rho GTPase Rac1 is activated upon virus infection and controls IRF-3 phosphorylation and activity. Inhibition of Rac1 leads to reduced IFN beta promoter activity and to enhanced virus production. As a downstream mediator of Rac signaling towards IRF-3, we have identified the kinase p21-activated kinase (PAK1). Furthermore, both Rac1 and PAK1 regulate the recently described IRF-3 activators, I kappa B kinase- and TANK-binding kina…
Rationale and design of the DARWIN-T2D (DApagliflozin Real World evIdeNce in Type 2 Diabetes): A multicenter retrospective nationwide Italian study a…
2017
Background Randomized controlled trials (RCTs) in the field of diabetes have limitations inherent to the fact that design, setting, and patient characteristics may be poorly transferrable to clinical practice. Thus, evidence from studies using routinely accumulated clinical data are increasingly valued. Aims We herein describe rationale and design of the DARWIN-T2D (DApagliflozin Real World evIdeNce in Type 2 Diabetes), a multicenter retrospective nationwide study conducted at 50 specialist outpatient clinics in Italy and promoted by the Italian Diabetes Society. Data synthesis The primary objective of the study is to describe the baseline clinical characteristics (particularly HbA1c) of pa…
Hard Two-Photon Contribution to Elastic Lepton-Proton Scattering Determined by the OLYMPUS Experiment
2017
The OLYMPUS collaboration reports on a precision measurement of the positron-proton to electron-proton elastic cross section ratio, $R_{2\gamma}$, a direct measure of the contribution of hard two-photon exchange to the elastic cross section. In the OLYMPUS measurement, 2.01~GeV electron and positron beams were directed through a hydrogen gas target internal to the DORIS storage ring at DESY. A toroidal magnetic spectrometer instrumented with drift chambers and time-of-flight scintillators detected elastically scattered leptons in coincidence with recoiling protons over a scattering angle range of $\approx 20\degree$ to $80\degree$. The relative luminosity between the two beam species was mo…
Innovative sequential batch reactor solutions for wastewater treatment
2019
Sekwencyjne biologiczne reaktory (SBR) są szeroko wykorzystywane do oczyszczania ścieków, które obecnie stają się zanieczyszczone coraz to nowymi i bardziej złożonymi substancjami. Korzystne zatem staje się włączenie różnego rodzaju rozszerzających się konfiguracji oraz modyfikacji operacyjnych, aby efektywniej oczyszczać ścieki. W pracy przedstawiono podstawowy opis procesu SBR oraz jego modyfikacji, które prowadzą do lepszego usuwania powstających zanieczyszczeń. Scharakteryzowano cykliczny system osadów czynnych (CASS), który jest jednym z najpopularniejszych procesów reaktorów sekwencyjnych (SBR) stosowanych do oczyszczania ścieków komunalnych oraz ścieków z różnych branż, w tym rafiner…
Discharge management in fresh and brackish water RAS: Combined phosphorus removal by organic flocculants and nitrogen removal in woodchip reactors
2020
The current study combined P and N removal using organic flocculant chemicals and woodchip bioreactors in both freshwater and brackish water (7 ppm) recirculating aquaculture systems (RAS). The use of carbon (C) containing flocculant chemicals in the process was hypothesized to further stimulate C-demanding N removal (denitrification) in bioreactors. The trial of combined P and N removal consisted of four treatments: freshwater and brackish water RAS with and without the addition of supernatant from flocculation process to the woodchip reactor. Duplicate woodchip reactors were used per treatment and the trial was run for six weeks. 56 % and 49 % of P was removed from fresh and brackish slud…
Rescriptum Constantini de quadraginta annorum praescriptione (FIRA, I, 96 e FIRA, III, 101)
2012
This study provides the full text of the P. Col. VII. 175 translated into Italian, concerning the transcript of a hearing conducted in front of Arsinoite’s σύνδικος in A.D. 339, and known in the field of doctrine as it cites a Constantine’s constitution regarding the longissimi temporis praescriptio. After reconstructing the trial and the early events preceding the lawsuit, defining the trial roles and detecting the nature of action and the reason why it was filed, the author has analysed the different juridical profiles of the text such as the evidence of the judicial function of the ἐπάρχος τῆς Αἰγύπτου; the judgemental function of the σύνδικος and the difficulty of identifying him as the…