Search results for "Actor"
showing 10 items of 19159 documents
Risk Factors for Parental Burnout among Finnish Parents: The Role of Socially Prescribed Perfectionism
2019
Abstract Objectives Although parental burnout can have detrimental consequences to families, the investigation of the syndrome is still in its infancy. The present study investigated what are the key family background variables that contribute to parental burnout among Finnish parents. Moreover, we investigated how self-oriented and socially prescribed perfectionism uniquely and interactively relate to parental burnout over and above the impacts of background variables. Methods Questionnaire-based data was collected from 1725 parents (91% mothers) and analyzed using structural equation modeling (SEM). Results The results showed that when several family- and child-related background variable…
Infrastructural and Human Factors Affecting Safety Outcomes of Cyclists
2018
The increasing number of registered road crashes involving cyclists during the last decade, and the high proportion of road crashes resulting in severe injuries and fatalities among cyclists constitutes a global issue for community health, urban development, and sustainability. Nowadays, the incidence of many risk factors for road crashes of cyclists remains largely unexplained. Given the importance of this issue, the present study has been conducted with the aim of determining relationships between infrastructural, human factors and safety outcomes of cyclists. Objectives: This study aimed, first, to examine the relationship between key infrastructural and human factors present in cycling,…
Consensus nomenclature for CD8(+) T cell phenotypes in cancer
2015
International audience; Whereas preclinical investigations and clinical studies have established that CD8+ T cells can profoundly affect cancer progression, the underlying mechanisms are still elusive. Challenging the prevalent view that the beneficial effect of CD8+ T cells in cancer is solely attributable to their cytotoxic activity, several reports have indicated that the ability of CD8+ T cells to promote tumor regression is dependent on their cytokine secretion profile and their ability to self-renew. Evidence has also shown that the tumor microenvironment can disarm CD8+ T cell immunity, leading to the emergence of dysfunctional CD8+ T cells. The existence of different types of CD8+ T…
COVID-19 in Severe Asthma Network in Italy (SANI) patients: Clinical features, impact of comorbidities and treatments
2020
To the Editor Since the end of February 2020 Italy, first non- Asian Country, has reported an ever increasing number of COronaVIrus Disease 19 (COVID-19) patients, which has reached over 200,000 confirmed Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) infected subjects and resulted in more than 34000 deaths (data updated to June 19th, 20201).Patients with asthma are potentially more severely affected by by SARS-CoV-2 infection 2 and it is well established that respiratory viral infections are associated with severe adverse outcomes in patients with asthma, including increased risk of asthma exacerbation episodes 3. Nonetheless, according to the epidemiological studies publishe…
Identification of a new nonsense mutation (Tyr129Stop) of the SRY gene in a newborn infant with XY sex-reversal.
2004
Point mutations and deletions of SRY gene have been described in several cases of XY gonadal dysgenesis. To date, most of these mutations affect the HMG domain of SRY which plays a central role in DNA binding activity of SRY. We report on a non-mosaic XY sex-reversed newborn girl (completely female external genitalia). The direct sequencing of SRY showed a new nonsense mutation in a codon of SRY gene flanking the 3' end of the HMG domain: a thymine is replaced by a guanine at position +387 in codon 129, resulting in the replacement of the amino acid tyrosine (TAT) by a stop codon (TAG). The new mutation of this patient provides further evidence to support the functional importance of the pu…
Talleres de Apoyo a la Investigación en CC Sociales: Fuentes y herramientas de información y evaluación Sexenios 2015. Área de Ciencias Jurídicas
2015
Taller impartido en la Biblioteca de Ciències Socials "Gregori Maians" sobre búsqueda de indicios de calidad en las revistas científicas con vistas a la convocatoria de la CNEAI de 2015. En el taller se buscan indicios de calidad en JCR, SJR así como en otras herramientas de evaluación como SPI, RESH, CIRC 2.0, Carhus+, MIAR, Latindex, Dialnet, Google Scholar Metrics, etc. Por último, se busca el número de citas recibidas en WoS, Scopus y Google Sccholar.
Development and validation of the Adolescent Sexting Scale (A-SextS) with a Spanish sample
2020
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Spectrum-shape method and the next-to-leading-order terms of the β-decay shape factor
2017
Effective values of the axial-vector coupling constant gA have lately attracted much attention due to the prominent role of gA in determining the half-lives of double β decays, in particular their neutrinoless mode. The half-life method, i.e., comparing the calculated half-lives to the corresponding experimental ones, is the most widely used method to access the effective values of gA. The present paper investigates the possibilities offered by a complementary method: the spectrum-shape method (SSM). In the SSM, comparison of the shapes of the calculated and measured β electron spectra of forbidden nonunique β decays yields information on the magnitude of gA. In parallel, we investigate the…
Development of New Targeted Inulin Complex Nanoaggregates for siRNA Delivery in Antitumor Therapy.
2021
Here, a novel strategy of formulating efficient polymeric carriers based on the already described INU-IMI-DETA for gene material whose structural, functional, and biological properties can be modulated and improved was successfully investigated. In particular, two novel derivatives of INU-IMI-DETA graft copolymer were synthesized by chemical functionalisation with epidermal growth factor (EGF) or polyethylenglycol (PEG), named INU-IMI-DETA-EGF and INU-IMI-DETA-PEG, respectively, in order to improve the performance of already described “inulin complex nanoaggregates” (ICONs). The latter were thus prepared by appropriately mixing the two copolymers, by varying each component from 0 to 100 wt%…
Algunas puntualizaciones sobre los orígenes del teatro popular en España: el caso de Lope de Rueda
1991
Se analiza el nacimiento del denominado teatro popular en España en la primera mitad del siglo XVI, centrado en el caso de Lope de Rueda