Search results for "Acyl-CoA"

showing 2 items of 42 documents

Disturbances in cholesterol, bile acid and glucose metabolism in peroxisomal 3-ketoacylCoA thiolase B deficient mice fed diets containing high or low…

2014

SPE IPM UB; International audience; : The peroxisomal 3-ketoacyl-CoA thiolase B (ThB) catalyzes the thiolytic cleavage of straight chain 3-ketoacyl-CoAs. Up to now, the ability of ThB to interfere with lipid metabolism was studied in mice fed a routinely laboratory chow enriched or not with the synthetic agonist Wy14,643, a pharmacological activator of the nuclear hormone receptor PPARα. The aim of the present study was therefore to determine whether ThB could play a role in obesity and lipid metabolism when mice are chronically fed a synthetic High Fat Diet (HFD) or a Low Fat Diet (LFD) as a control diet. To investigate this possibility, wild-type (WT) mice and mice deficient for Thb (Thb(…

lathosterol.medicine.medical_specialtymedicine.drug_classLathosterolCarbohydrate metabolismBiologyCholesterol 7 alpha-hydroxylaseDiet High-FatBiochemistrylathosterolBile Acids and Saltschemistry.chemical_compoundMiceInternal medicineIntestine Smallmedicine[SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular BiologyAnimals[SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular BiologyInsulin-Like Growth Factor I[ SDV.BBM ] Life Sciences [q-bio]/Biochemistry Molecular Biology2. Zero hunger[SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolismbile acidsBile acidFatty acid metabolismCholesterolCholesterol HDLfood and beveragesLipid metabolismGeneral Medicine[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism[ SDV.MHEP.EM ] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolismAcetyl-CoA C-AcyltransferaseDietary FatsLiver GlycogenEndocrinologyCholesterolGlucosehypoglycemiade novo biosynthesis of cholesterolchemistryGrowth HormoneACOX1lipids (amino acids peptides and proteins)peroxisomal 3-ketoacyl-CoA thiolase B
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Progressive Endoplasmic Reticulum Stress Contributes to Hepatocarcinogenesis in Fatty Acyl-CoA Oxidase 1–Deficient Mice

2011

Fatty acyl-coenzyme A oxidase 1 (ACOX1) knockout (ACOX1(-/-)) mice manifest hepatic metabolic derangements that lead to the development of steatohepatitis, hepatocellular regeneration, spontaneous peroxisome proliferation, and hepatocellular carcinomas. Deficiency of ACOX1 results in unmetabolized substrates of this enzyme that function as biological ligands for peroxisome proliferator-activated receptor-α (PPARα) in liver. Here we demonstrate that sustained activation of PPARα in ACOX1(-/-) mouse liver by these ACOX1 substrates results in endoplasmic reticulum (ER) stress. Overexpression of transcriptional regulator p8 and its ER stress-related effectors such as the pseudokinase tribbles h…

medicine.medical_specialtyGenotypePeroxisome proliferator-activated receptorPeroxisome ProliferationMice TransgenicBiologyEndoplasmic ReticulumModels BiologicalPathology and Forensic MedicineMiceInternal medicinemedicineAnimalsHumansAcyl-CoA oxidasePPAR alphaTransgenesDNA Primerschemistry.chemical_classificationLiver cellEndoplasmic reticulumLiver NeoplasmsRegular ArticlePeroxisomemedicine.diseaseNeoplasm ProteinsCell biologyDNA-Binding ProteinsMice Inbred C57BLEndocrinologyGene Expression RegulationLiverchemistryHepatocytesUnfolded protein responseAcyl-CoA OxidaseSteatohepatitisThe American Journal of Pathology
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