Search results for "Ada"
showing 10 items of 10244 documents
Inhibitory effects of okadaic acid on rat uterine contractile responses to different spasmogens
1997
In the present study, we examined the effects of okadaic acid, a selective inhibitor of type I and 2A protein phosphatases, on the mechanical responses evoked by oxytocin, K + - and Na + -modified solutions and ouabain in estrogen-primed rat myometrium. Oxytocin elicited a rapid, phasic contraction followed by rhythmic oscillations. The phasic response was partially resistant to the absence of external Ca 2+ . Okadaic acid (1 μM) and the L-type calcium channel blocker nifedipine (1 μM) abolished the oscillatory component and reduced the initial, phasic response to about 80% of the control response. High K + (60 mM) solution, ouabain (1 mM), K + -free medium and low Na + (25 mM) solution ind…
Are go/no-go tasks preferable to two-choice tasks in response time experiments with older adults?
2015
Epub ahead of print 02/11/2015 Recent research has shown that, in response time (RT) tasks, the go/no-go response procedure produces faster (and less noisy) RTs and fewer errors than the two-choice response procedure in children, although these differences are substantially smaller in college-aged adults. Here we examined whether the go/no-go procedure can be preferred to the two-choice procedure in RT experiments with older adults (i.e. another population with slower and more error-prone responding than college-aged individuals). To that end, we compared these response procedures in two experiments with older adults (Mage = 83 years): a visual word recognition task (lexical decision) and a…
Continuity of healthcare for headacahe patients: a problem of communication between headache specialists and general pratictioners
2005
The continuous care of headache patients, from headache centres to general practice, is a managerial problem that is still unsolved in Italy. In fact, if on the one hand patients do not usually go to headache centres because of poor information, on the other hand, if they do, they do not find their general practitioner (GP) sufficiently prepared to continue the management. In Sicily we have formed a dense network of headache centres that we will try to link on the Internet to deal with the problem of poor patients information and poor specialist consultation. We also have faced the problem of the continuous care, trying to overcome "the difficulties of communication between specialists, GPs…
The Global Campaign (GC) to Reduce the Burden of Headache Worldwide. The International Team for Specialist Education (ITSE)
2005
The social perception of headache, everywhere at low levels in industrialised countries, becomes totally absent in developing ones. Headache disorders came into the World Health Organization’s strategic priorities after publication of the 2001 World Health Report. Among the leading causes of disability, migraine was ranked 19th for adults of both sexes together and 12th for females. The Global Campaign (GC) to Reduce the Burden of Headache Worldwide was planned by the major international headache organizations together with WHO in order to identify and remove those cultural, social and educational barriers recognised as responsible factors for the inadequate treatment of headache disorders …
Community detection-based deep neural network architectures: A fully automated framework based on Likert-scale data
2020
[EN] Deep neural networks (DNNs) have emerged as a state-of-the-art tool in very different research fields due to its adaptive power to the decision space since they do not presuppose any linear relationship between data. Some of the main disadvantages of these trending models are that the choice of the network underlying architecture profoundly influences the performance of the model and that the architecture design requires prior knowledge of the field of study. The use of questionnaires is hugely extended in social/behavioral sciences. The main contribution of this work is to automate the process of a DNN architecture design by using an agglomerative hierarchical algorithm that mimics th…
Advanced technologies for detecting tremor in Parkinson's disease.
2019
Objective Accurate and reliable detection of tremor onset in Parkinson’s disease (PD) is critical to the success of adaptive deep brain stimulation (aDBS) therapy. Here, we investigated the potential use of feature engineering and machine learning methods for more accurate detection of rest tremor in PD. Methods We analyzed the local field potential (LFP) recordings from the subthalamic nucleus region in 12 patients with PD (16 recordings). To explore the optimal biomarkers and the best performing classifier, the performance of state-of-the-art machine learning (ML) algorithms and various features of the subthalamic LFPs were compared. We further used a Kalman filtering technique in feature…
Osmophobia in migraine classification: a multicentre study in juvenile patients.
2010
Aims: This study was planned to investigate the diagnostic utility of osmophobia as criterion for migraine without aura (MO) as proposed in the Appendix (A1.1) of the International Classification of Headache Disorders (ICHD-II, 2004). Methods: We analysed 1020 patients presenting at 10 Italian juvenile headache centres, 622 affected by migraine (M) and 328 by tension-type headache (TTH); 70 were affected by headache not elsewhere classified (NEC) in ICHD-II. By using a semi-structured questionnaire, the prevalence of osmophobia was 26.9%, significantly higher in M than TTH patients (34.6% vs 14.3%). Results: Osmophobia was correlated with: (i) family history of M and osmophobia; and (ii) o…
Headache attributed to head or neck trauma
2010
Publisher Summary This chapter presents an overview of all types of posttraumatic headache (PTH): acute PTH, chronic PTH, and headache after a whiplash injury, taking account of the definition and latest criteria of International Headache Classification II (ICHD-II). Headache is a symptom that may occur after injury to the head, neck, or brain. PTH is a cardinal symptom of the “postconcussion syndrome” and may be accompanied by somatic, psychological, or cognitive disturbances. PTH is always a new-onset headache resulting from brain, head, and sometimes neck injury, and can simulate the clinical characteristics of several primary headaches. Severe, moderate, and mild head injuries can cause…
Calcium Dependence of the Mechanical Response Evoked by Okadaic Acid in Smooth Muscle
1995
The effects of okadaic acid (OA), obtained from a culture of the marine dinoflagellate Prorocentrum Lima were studied on isolated strips of rat myometrium. The contractile response evoked by OA at 5, 10, and 20 μM in normal physiological solution was unaffected in the presence of tetrodotoxin (10 μM), indomethacin (3 μM), or a cocktail of antagonists which blocked muscarinic, adrenergic, histaminergic, serotonergic, and opioid receptors. Similarly, the response to OA was unaffected in the presence of nifedipine at a concentration (1 μM) which completely or highly blocked the response to KCl (60 mM), oxytocin (1 μM), or acetylcholine (100 μM). In a Ca 2+ -free 1 mM EGTA-containing solution, …
Effects of military basic training on VO2max, body composition, muscle strength and neural responses in conscripts of different aerobic condition
2019
Summary Study aim: The purpose of this study was to evaluate neuromuscular adaptations in conscripts with different fitness levels (VO2max) during 8 weeks of military basic training (BT). Material and methods: Twenty-four male conscripts (18–21 years) were divided into two groups (Good Fitness [GF] and Low fitness [LF]) based on their VO2max at the beginning of BT. Body mass (BM), fat free mass (FFM) and Fat% were measured after 2, 4, and 7 weeks of training. VO2max, maximal isometric leg press force (MVC), H-reflex (Hmax/Mmax) at rest and V-wave (V/Mmax) during maximal isometric plantarflexion were measured from the soleus muscle at the beginning, after 5, and after 8 weeks of training. Re…