Search results for "Adam"

Las armas de la falsedad masiva / y 2

2004

Un olor a dólares

2003

La guerra de Irak, una hazaña épica

2003

Holo-APP and G-protein-mediated signaling are required for sAPPa-induced activation of the Akt survival pathway

2014

International audience; Accumulating evidence indicates that loss of physiologic amyloid precursor protein (APP) function leads to reduced neuronal plasticity, diminished synaptic signaling and enhanced susceptibility of neurons to cellular stress during brain aging. Here we investigated the neuroprotective function of the soluble APP ectodomain sAPPa (soluble APPa), which is generated by cleavage of APP by a-secretase along the non-amyloidogenic pathway. Recombinant sAPPa protected primary hippocampal neurons and SH-SY5Y neuroblastoma cells from cell death induced by trophic factor deprivation. We show that this protective effect is abrogated in neurons from APP-knockout animals and APP-de…

α-Secretase Activity of the Disintegrin Metalloprotease ADAM 10: Influences of Domain Structure

2001

Disintegrin metalloproteases from different organisms form the ADAM (a disintegrin and metalloprotease) family. All members display a common domain organization and possess four potential functions: proteolysis, cell adhesion, cell fusion, and cell signaling. Members of the ADAM family are responsible for the proteolytic cleavage of transmembrane proteins and release of their extracellular domain. The proteolytic process is referred to as ectodomain shedding, which is activated by phorbol esters and inhibited by hydroxamic acid-based inhibitors. We have shown that the disintegrin metalloprotease ADAM 10 has both constitutive and regulated alpha-secretase activity. Expression of a dominant n…

Activation of α-secretase cleavage

2011

Alpha-secretase-mediated cleavage of the amyloid precursor protein (APP) releases the neuroprotective APP fragment sαAPP and prevents amyloid β peptide (Aβ) generation. Moreover, α-secretase-like cleavage of the Aβ transporter 'receptor for advanced glycation end products' counteracts the import of blood Aβ into the brain. Assuming that Aβ is responsible for the development of Alzheimer's disease (AD), activation of α-secretase should be preventive. α-Secretase-mediated APP cleavage can be activated via several G protein-coupled receptors and receptor tyrosine kinases. Protein kinase C, mitogen-activated protein kinases, phosphatidylinositol 3-kinase, cAMP and calcium are activators of rece…

Il kimono di Odette. Riflessi del japonisme nella musica europea del primo Novecento

2019

Il testo delinea il quadro degli influssi del japonisme nell'ambito della musica francese e italiana dei primi anni del XX secolo, con particolare riferimento a Claude Debussy ("La mer"), Pietro Mascagni ("Iris") e Giacomo Puccini (Madama Butterfly"). Particolare attenzione è infine riservata alle "Trois Poésies de la Lyrique Japonaise" per voce e piccolo ensemble di Igor Stravinsky (1912).

Evaluation of Clotting Factor Concentrates for Treatment of Thrombotic Thrombocytopenic Purpura.

2010

Abstract Abstract 3678 Introduction: Thrombotic thrombocytopenic purpura (TTP) is characterized by microthrombi, hemolytic anemia as well as thrombocytopenia. These symptoms are caused by a decreased activity of the protease ADAMTS13 which cleaves the von Willebrand Factor (VWF), due to mutation of the ADAMTS13-gene or autoantibodies. At the moment, the only available immediate therapy is plasmapheresis with Fresh Frozen Plasma (FFP) which may induce side effects. Therefore an alternative therapy might be the treatment with clotting factor concentrates. Methods: 40 plasma samples were tested, consisting of FFP and solvent/detergent treated plasma, four batches of each blood group; VWF/VIII …

A Criterion for Attaining the Welch Bounds with Applications for Mutually Unbiased Bases

2008

The paper gives a short introduction to mutually unbiased bases and the Welch bounds and demonstrates that the latter is a good technical tool to explore the former. In particular, a criterion for a system of vectors to satisfy the Welch bounds with equality is given and applied for the case of MUBs. This yields a necessary and sufficient condition on a set of orthonormal bases to form a complete system of MUBs. This condition takes an especially elegant form in the case of homogeneous systems of MUBs. We express some known constructions of MUBs in this form. Also it is shown how recently obtained results binding MUBs and some combinatorial structures (such as perfect nonlinear functions an…

Some Hadamard designs with parameters (71,35,17)

2002

Up to isomorphisms there are precisely eight symmetric designs with parameters (71, 35, 17) admitting a faithful action of a Frobenius group of order 21 in such a way that an element of order 3 fixes precisely 11 points. Five of these designs have 84 and three have 420 as the order of the full automorphism group G. If |G| = 420, then the structure of G is unique and we have G = (Frob21 × Z5):Z4. In this case Z(G) = 〈1〉, G′ has order 35, and G induces an automorphism group of order 6 of Z7. If |G| = 84, then Z(G) is of order 2, and in precisely one case a Sylow 2-subgroup is elementary abelian. © 2002 Wiley Periodicals, Inc. J Combin Designs 10: 144–149, 2002; DOI 10.1002/jcd.996