Search results for "Adapta"
showing 10 items of 1961 documents
Translational adaptation to heat stress is mediated by RNA 5‐methylcytosine in Caenorhabditis elegans
2021
Abstract Methylation of carbon‐5 of cytosines (m5C) is a post‐transcriptional nucleotide modification of RNA found in all kingdoms of life. While individual m5C‐methyltransferases have been studied, the impact of the global cytosine‐5 methylome on development, homeostasis and stress remains unknown. Here, using Caenorhabditis elegans, we generated the first organism devoid of m5C in RNA, demonstrating that this modification is non‐essential. Using this genetic tool, we determine the localisation and enzymatic specificity of m5C sites in the RNome in vivo. We find that NSUN‐4 acts as a dual rRNA and tRNA methyltransferase in C. elegans mitochondria. In agreement with leucine and proline bein…
Content, cost, and context: A framework for understanding human signaling systems
2019
Humans frequently perform extravagant and seemingly costly behaviors, such as widely sharing hunted resources, erecting conspicuous monumental structures, and performing dramatic acts of religious devotion. Evolutionary anthropologists and archeologists have used signaling theory to explain the function of such displays, drawing inspiration from behavioral ecology, economics, and the social sciences. While signaling theory is broadly aimed at explaining honest communication, it has come to be strongly associated with the handicap principle, which proposes that such costly extravagance is in fact an adaptation for signal reliability. Most empirical studies of signaling theory have focused on…
From the Editor in Chief: The Axes for the Modern Age
2020
Application of the SWAP model to predict impact of climate change on soil water balance in a Sicilian vineyard
2012
In Sicily, the increasing scarcity of quality water is leading to irrigation with saline water in soils having a considerable susceptibility to salinization and degradation. In this paper, water flow and solute transport in a Sicilian irrigated soil was simulated by using the SWAP model, and the simulated results compared to measured values of soil moisture and salinity. The investigation was carried out in a vineyard located in Sicily (Mazara del Vallo, Trapani Province) within the framework of the Project: Evolution of cropping systems as affected by climate change (CLIMESCO). The soil hydraulic parameters were obtained by inverse method based on multi-step outflow experiments. The result…
Coping with cyclic oxygen availability: evolutionary aspects
2007
Both the gradual rise in atmospheric oxygen over the Proterozoic Eon as well as episodic fluctuations in oxygen over several million-year time spans during the Phanerozoic Era, have arguably exerted strong selective forces on cellular and organismic respiratory specialization and evolution. The rise in atmospheric oxygen, some 2 billion years after the origin of life, dramatically altered cell biology and set the stage for the appearance of multicelluar life forms in the Vendian (Ediacaran) Period of the Neoproterozoic Era. Over much of the Paleozoic, the level of oxygen in the atmosphere was near the present atmospheric level (21%). In the Late Paleozoic, however, there were extended times…
La participación de personas con discapacidad en proyectos I+D+i. Buenas prácticas para la inclusión de personas con parálisis cerebral discinética e…
2017
En la actualidad, diferentes movimientos, como la sociedad del conocimiento, la economía del bien común o la economía de la calidad de vida, consideran necesario trabajar por una sociedad que, frente al consumismo y la tecnología como motores de desarrollo, anteponga la calidad de vida de las personas y oriente la innovación a escuchar y satisfacer sus necesidades, preferencias y expectativas. En este contexto, el ámbito de la I+D+i se está esforzando en desarrollar y adoptar estrategias que cubren las facetas sociales, ofreciendo alternativas a la innovación tecnológica, de forma que el conocimiento y la innovación basada en la colaboración de la ciudadanía se conviertan en los motores de …
Cultural adaptation of the Smiling is Fun program for the treatment of depression in the Ecuadorian public health care system: A study protocol for a…
2021
Background Depression is one of the world's major health problems. Due to its high prevalence, it constitutes the first cause of disability among the Americas, where only a very low percentage of the population receives the adequate evidence-based psychological treatment. Internet-Based Interventions (IBIs) are a great alternative to reduce the treatment gap for mental disorders. Although there are several studies in low-and middle-income countries proving IBIs' feasibility and acceptability, there is still little evidence of the effectiveness in diverse social and cultural contexts such as Latin America. Methods Two studies will be described: Study 1 is focused on the cultural adaptation o…
Link Adaptation Thresholds for the IEEE 802.16 Base Station
2008
The IEEE 802.16 technology defines a number of modulation and coding schemes that the base station can use to achieve the best tradeoff between the spectrum efficiency and the resulting application level throughput. However, the 802.16 specification does not define any particular link level adaptation algorithm, neither does it specify the SNR thresholds to switch between modulation and coding schemes. In this paper we consider a link adaptation model and conduct a number of simulation runs to find transition thresholds for ARQ and HARQ retransmission mechanisms. All the simulations are done with the 802.16 extension for the NS-2 simulator.
DNA Methylation and Non-Coding RNAs during Tissue-Injury Associated Pain.
2022
While about half of the population experience persistent pain associated with tissue damages during their lifetime, current symptom-based approaches often fail to reduce such pain to a satisfactory level. To provide better patient care, mechanism-based analgesic approaches must be developed, which necessitates a comprehensive understanding of the nociceptive mechanism leading to tissue injury-associated persistent pain. Epigenetic events leading the altered transcription in the nervous system are pivotal in the maintenance of pain in tissue injury. However, the mechanisms through which those events contribute to the persistence of pain are not fully understood. This review provides a summar…
Alternative methods for strength development : the case of motor imagery and neuromuscular electrical stimulation
2020
An intense practice of resistance training, i.e. with heavy loads and a low number of repetitions, can cause injuries. To avoid them or limit detraining after an injury, alternative training methods have been developed. These methods have a double target since they also allow populations with different pathologies to practice a physical activity. This thesis focused particularly on the neuromuscular system and the mechanisms involved in strength development on plantar flexors muscles following motor imagery (MI), i.e. mental simulation of a movement without its concomitant motor output, and neuromuscular electrical stimulation (NMES), i.e. evoking contractions through electrical current app…