Search results for "Adaptive"
showing 10 items of 792 documents
Vascular Endothelial Growth Factor, a Key Modulator of the Anti-Tumor Immune Response
2021
During tumor growth, angiogenesis is required to ensure oxygen and nutrient transport to the tumor. Vascular endothelial growth factor (VEGF) is the major inducer of angiogenesis and appears to be a key modulator of the anti-tumor immune response. Indeed, VEGF modulates innate and adaptive immune responses through direct interactions and indirectly by modulating protein expressions on endothelial cells or vascular permeability. The inhibition of the VEGF signaling pathway is clinically approved for the treatment of several cancers. Therapies targeting VEGF can modulate the tumor vasculature and the immune response. In this review, we discuss the roles of VEGF in the anti-tumor immune respon…
The impact of tumor nitric oxide production on VEGFA expression and tumor growth in a zebrafish rat glioma xenograft model.
2015
International audience; To investigate the effect of nitric oxide on tumor development, we established a rat tumor xenograft model in zebrafish embryos. The injected tumor cells formed masses in which nitric oxide production could be detected by the use of the cell-permeant DAF-FM-DA (diaminofluorophore 4-amino-5-methylamino-2'-7'-difluorofluorescein diacetate) and DAR-4M-AM (diaminorhodamine-4M). This method revealed that nitric oxide production could be co-localized with the tumor xenograft in 46% of the embryos. In 85% of these embryos, tumors were vascularized and blood vessels were observed on day 4 post injection. Furthermore, we demonstrated by qRT-PCR that the transplanted glioma ce…
A mathematical model for the therapy of the HIV infection
2005
In this paper we consider the evolution of the HIV infection under a highly effective treatment based on a combination of RTI and/or PI drugs. This is usually modelled with a set of ODEs where the drug efficacy is a constant. In this paper we consider the treatment efficacy as a dynamic variable which evolves during the treatment. To model the dynamics of the drug efficacy we use an evolutive type assumption. The resulting set of ODEs are able to reproduce the typical pattern of the illness evolution under treatment: a period of remission, which can last several years, followed by a progressive recrudescence and a viral rebound.
Temporal multiplexing with adaptive optics for simultaneous vision.
2016
We present and test a methodology for generating simultaneous vision with a deformable mirror that changed shape at 50 Hz between two vergences: 0 D (far vision) and −2.5 D (near vision). Different bifocal designs, including toric and combinations of spherical aberration, were simulated and assessed objectively. We found that typical corneal aberrations of a 60-year-old subject changes the shape of objective through-focus curves of a perfect bifocal lens. This methodology can be used to investigate subjective visual performance for different multifocal contact or intraocular lens designs.
Adaptive Vocabulary Learning Environment for Late Talkers
2016
The main aim of this research is to provide children who have an early language delay with an adaptive way to train their vocabulary taking into account individuality of the learner. The suggested system is a mobile game-based learning environment which provides simple tasks where the learner chooses a picture that corresponds to a played back sound from multiple pictures presented on the screen. Our basic assumption is that the more similar the concepts (in our case, words) are, the harder the recognition task is. The system chooses the pictures to be presented on the screen by calculating the distances between the concepts in different dimensions. The distances are considered to consist o…
Gully Erosion Susceptibility Mapping Using Multivariate Adaptive Regression Splines—Replications and Sample Size Scenarios
2019
Soil erosion is a serious problem affecting numerous countries, especially, gully erosion. In the current research, GIS techniques and MARS (Multivariate Adaptive Regression Splines) algorithm were considered to evaluate gully erosion susceptibility mapping among others. The study was conducted in a specific section of the Gorganroud Watershed in Golestan Province (Northern Iran), covering 2142.64 km2 which is intensely influenced by gully erosion. First, Google Earth images, field surveys, and national reports were used to provide a gully-hedcut evaluation map consisting of 307 gully-hedcut points. Eighteen gully erosion conditioning factors including significant geoenvironmental and morph…
Applicability of a binary amplitude mask for creating correctors of higher-order ocular aberrations in a photoresistive layer
2012
Ocular aberrations can be corrected with wavefront correctors created in a photoresist layer. The simplest type of the mask used in optical lithography is a binary amplitude mask. It is known that such a mask has a periodic hole pattern. The purpose of this research was to assess applicability of a binary amplitude mask for creating ocular wavefront correctors. The photoresist was applied to the substrate by using the dip-coating method. The photoresist layer was illuminated through a mask printed on a transparent film by using a laser printer. The surface of the wavefront correctors was evaluated by aberrometry, scanning electron microscopy and profilometry method. The dip-coating method c…
<title>Photoinduced AsSeS thin film phase plates as adaptive optics mirrors for eye aberration correction</title>
2008
Amorphous chalcogenide thin films are excellent materials for holographic recordings. AsSeS thin film coating is a useful optical material for it's thickness to be easily corrected with the use of exposure to light and consecutive chemical etching. Following properties allow to treat the surface of AsSeS chalcogenide films and to use them in adaptive optics systems for correction of the optical wavefront. Hereby, we characterize AsSeS film properties to be used for correction of optical aberrations of the human eye. The thickness of the film is characterized with the method of spectrodensitometry and the surface profile depth with a Hartman- Shack waveform analyzator.
Optical phase retrieval using four rotated versions of a single binary mask – simulation results
2018
In signal processing one often faces the phase problem, i.e., when an image is formed information about the phase is lost so that only information about intensity is available. This is often an issue in astronomy, biology, crystallography, speckle imaging, diffractive imaging where the phase of the object must be known. While there have been many approaches how to find a solution to the phase problem, numerical algorithms recovering the phase from intensity measurements become more and more popular. One of such algorithms called PhaseLift has been recently proposed. In this study, we show that even 4 masks may be sufficient for reasonable recovery of the phase. The original wavefront and th…
Drifts in real-time partial wavefront correction and how to avoid them
2017
In visual experiments that require real-time partial correction of wavefront aberrations, small errors occur that accumulate over time and lead to drifts in Zernike coefficients of the uncorrected aberrations. A simple algorithm that does not require the inclusion of an additional optical path to obtain independent measurements of the eye's aberrations is described here, and its effectiveness in preventing these drifts is demonstrated.