Search results for "Addiction"
showing 10 items of 415 documents
Modelos animales de adicción a las drogas
2017
El desarrollo de modelos animales de refuerzo y adicción a las drogas es imprescindible para el avance en el conocimiento de las bases biológicas de este trastorno y la identificación de nuevas dianas terapéuticas. En función del componente del refuerzo que deseemos estudiar podemos servirnos de un tipo de modelos animales u otros. Podemos utilizar modelos de refuerzo basados en el efecto hedónico primario que produce el consumo de la sustancia adictiva, como los modelos de autoadministración (AA) y autoestimulación eléctrica intracraneal (AEIC), o modelos basados en el componente relacionado con el aprendizaje asociativo y la capacidad cognitiva de realizar predicciones sobre la obtención …
Homer2 and alcohol: A mutual interaction
2017
The past two decades of data derived from addicted individuals and preclinical animal models of addiction implicate a role for the excitatory glutamatergic transmission within the mesolimbic structures in alcoholism. The cellular localization of the glutamatergic receptor subtypes, as well as their signaling efficiency and function, are highly dependent upon discrete functional constituents of the postsynaptic density, including the Homer family of scaffolding proteins. The consequences of repeated alcohol administration on the expression of the Homer family proteins demonstrate a crucial and active role, particularly for the expression of Homer2 isoform, in regulating alcohol-induced behav…
Acetaldehyde as the first hit of addictive behaviour
2016
Unhealthy alcohol use is common in the Western society, which puts risk of health consequences, causing multiple behavioural injuries. Increasing evidence focuses on acetaldehyde, the first metabolite of ethanol, as the mediator of the several behavioural actions of alcohol, including its rewarding and motivational effects. In particular, acetaldehyde induces dopamine release in the nucleus accumbens modulating primary alcohol rewarding effect, drug seeking, and relapse behaviour. Recent behavioural studies point at acetaldehyde as a drug of abuse since its oral self-administration is induced and maintained in an operant/conflict paradigm. These findings provide further evidence on the role…
Lateral Habenula 5-HT2C Receptor Function Is Altered by Acute and Chronic Nicotine Exposures
2021
Serotonin (5-HT) is important in some nicotine actions in the CNS. Among all the 5-HT receptors (5-HTRs), the 5-HT2CR has emerged as a promising drug target for smoking cessation. The 5-HT2CRs within the lateral habenula (LHb) may be crucial for nicotine addiction. Here we showed that after acute nicotine tartrate (2 mg/kg, i.p.) exposure, the 5-HT2CR agonist Ro 60-0175 (5–640 µg/kg, i.v.) increased the electrical activity of 42% of the LHb recorded neurons in vivo in rats. Conversely, after chronic nicotine treatment (6 mg/kg/day, i.p., for 14 days), Ro 60-0175 was incapable of affecting the LHb neuronal discharge. Moreover, acute nicotine exposure increased the 5-HT2CR-immunoreactive (IR)…
Le goût sucré, de l’enfance… à la dépendance ?
2013
Summary: Can one talk about addiction to sugar? Sugar is an important part of our diet, and an important source of pleasure, as of a young age. The definition of addiction involves that addictive substances act on the reward circuit, and lead to two symptoms, withdrawal and tolerance. Is it the case with sugar? According to the literature, brain activations in regions involved in the reward circuit are observed in response to “sugar”, and they differ according to the type of sugar (caloric carbohydrates, sweet or not; sweeteners). Besides, withdrawal and tolerance symptoms are not well characterized: food cravings often concern sweet foods, but there is a decrease with age of the preference…
The role of emotion dysregulation in adolescents’ problematic smartphone use: A study on adolescent/parents triads
2021
Abstract The pervasive use of mobile phones among adolescents has led researchers to evaluate the role of parental characteristics in connection with their children's problematic smartphone use (PSU). The present study involved mother/father/adolescent triads and aimed to test a model examining the role of both parents' and adolescents' emotion dysregulation (ED) in predicting children's PSU. Two hundred and fifty-two adolescent (57.5% females; M age = 13.54, SD = 0.73)/mother (M age = 43.92, SD = 4.46)/father (M age = 47.60, SD = 5.10) triads provided measures of PSU and ED. Results from path model showed that, after controlling for adolescents' age and gender as well as for parents' age a…
Understanding the Influence of Eating Patterns on Binge Drinking: A Mediation Model
2020
Background: Binge drinking is an important health problem, and it has been related to binge eating and fat intake in animal models, but this relationship has not been tested in humans. The first objective of this study was to analyze whether binge eating and fat intake are related to binge drinking in a youth sample. The second objective was to analyze whether binge eating and fat intake mediate the relationship between individual factors associated with binge eating and fat intake (sex, body mass index (BMI), drive for thinness, body dissatisfaction, eating styles, impulsivity, and food addiction) and binge drinking. Methods: A sample of 428 undergraduate students filled out several questi…
El papel de los problemas emocionales en la hipersexualidad
2020
Introducción: La hipersexualidad es un problema frecuente en la práctica clínica, especialmente por el malestar emocional que generan algunas de sus manifestaciones como la adicción al sexo. Sin embargo, la relación entre el malestar y la hipersexualidad no está clara y muchos autores resaltan que, además de una consecuencia, el malestar emocional podría ser causante de la búsqueda del sexo como una estrategia de regulación emocional. El objetivo del presente estudio es comprobar si existe relación entre el estado anímico y la conducta hipersexual tanto en hombres como en mujeres. Método: 400 participantes (69% hombres) entre los 18 y 40 años (M=26,65; DT=6,30) completaron una encuesta onli…
NUOVE DIPENDENZE. ETIOLOGIA, CLINICA E TRATTAMENTO DELLE DIPENDENZE "SENZA DROGA". VOLUME MONOGRAFICO RIVISTA NOOS
2008
IL VOLUME RACCOGLIE ARTICOLI RELATIVI AL TEMA DELLE DIPENDENZE SENZA DROGHE, CON PARTICOLARE RIFERIMENTO AL GIOCO D'AZZARDO, ALL'INTERNET ADDICTION, ALLO SHOPPING COMPULSIVO. TALI DISTURBI VENGONO AFFRONTATI DAL PUNTO DI VISTA ETIOLOGICO, DIAGNOSTICO E TERAPEUTICO.
1653 – The developemnt of adaptive and maladaptive patterns of internet use among european adolescents at risk for internet addictive behaviors: a gr…
2013
Introduction Full findings from the European Commission funded EU-NET-ADB study (Safer Internet Programme) will be presented. Objectives Empirical findings that elucidate the development of an internet addictive behaviour are still incomplete. This is also related to risk as well as protective factors of internet use. Here a process oriented approach to identify underlying conditions of an internet addictive behaviour was chosen. Aims The aim of the study is to enhance the knowledge and understanding of underlying processes which lead to situation were internet addictive behaviour can evolve. Methods In total 124 in-depth interviews were conducted with adolescents with an age of 14-17 year.…