Search results for "Adenohipofīze"

showing 2 items of 2 documents

Transkriptoma analīze akromegālijas pacientiem ar un bez medikamentozās terapijas

2019

Darba mērķis bija veikt somatotrofas hipofīzes adenomas audu transkriptoma analīzi pacientiem, kuri ir vai nav lietojuši medikamentozo terapiju pirms operācijas, analizējot SST/DA analogu izraisītās izmaiņas transkriptomā. Lai to realizētu tika izdalīts totālais RNS no pacientu somatotrofās hipofīzes adenomas audiem un sagatavotas transkriptoma bibliotēkas. Pēc tam iegūtie dati tika analizēti, izmantojot Galaxy platformu un programmu R un R Studio. Pēc datu analīzes tika iegūti 22 statistiski būtiski DEGs un no tiem viens būtiski iesaistīts signālceļš, kā arī intensitātes grafikā tika novērotas divas izteiktas gēnu grupas, kas iedalijās starp pacientiem atkarībā no medikamentozās terapijas.

TranskriptomsSomatotrofa adenomaAkromegālijaSST/DA analogiAdenohipofīzeBioloģija

researchProduct

Centrālās nervu sistēmas ietekme uz adenohipofīzes adenomu attīstību

2015

Adenohipofīzes adenomas ir labdabīgi intrakraniāli endokrīnie audzēji ar potenciāli augstu prevalenci populācijā. To rašanās rezultātā pacientiem var attīstīties plaša spektra veselības problēmas. Bakalaura darbā veikta adenohipofīzes adenomu šūnu izpēte, analizējot to proliferāciju un saistību ar CNS. Darba gaitā tika konstatētas dažādas CNS cilmes šūnām raksturīgās īpašības adenomu paraugos.

cilmes šūnasadenohipofīzes adenomasBioloģijacentrālā nervu sistēmaimunohistoķīmija

researchProduct

PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
  - PE2_1Theory of fundamental interactions
  - PE2_2 Phenomenology of fundamental interactions
  - PE2_3Experimental particle physics with accelerators
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  - PE2_6Nuclear, hadron and heavy ion physics
  - PE2_8Gas and plasma physics
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  - PE2_7Nuclear and particle astrophysics
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  - PE2_10Atomic, molecular physics
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  - PE10_13Physical geography, geomorphology
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  - PE11_12Semi-conducting and magnetic materials engineering
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  - PE11_14Computational methods for materials engineering
LSLife Sciences
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  - LS1_14Innovative methods and modelling in molecular, structural and synthetic biology
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- LS2Integrative Biology: from Genes and Genomes to Systems
  - LS2_1Genetics
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  - LS2_2Gene editing
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  - LS4_1Organ and tissue physiology and pathophysiology
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- LS3Cell Biology, Development, Stem Cells and Regeneration
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SHSocial Sciences and Humanities
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